CAS 2607-06-9

Diflucortolone

Description:

Diflucortolone is a synthetic corticosteroid with anti-inflammatory and immunosuppressive properties, primarily used in dermatology for the treatment of various skin conditions. It is characterized by its potent glucocorticoid activity, which helps reduce inflammation, itching, and redness associated with skin disorders. The chemical structure of diflucortolone includes a steroid backbone, which is essential for its biological activity. It is typically formulated in topical preparations, such as creams or ointments, allowing for localized treatment with minimal systemic absorption. Diflucortolone is known for its relatively low risk of side effects compared to other more potent corticosteroids, making it suitable for long-term use in certain cases. However, like all corticosteroids, it should be used judiciously to avoid potential adverse effects, such as skin thinning or systemic absorption leading to hormonal imbalances. Its efficacy and safety profile make it a valuable option in managing inflammatory skin diseases.

Formula: C₂₂H₂₈F₂O₄

InChI: InChI=1S/C22H28F2O4/c1-11-6-13-14-8-16(23)15-7-12(26)4-5-21(15,3)22(14,24)18(28)9-20(13,2)19(11)17(27)10-25/h4-5,7,11,13-14,16,18-19,25,28H,6,8-10H2,1-3H3/t11-,13+,14+,16+,18+,19-,20+,21+,22+/m1/s1

InChI key: InChIKey=OGPWIDANBSLJPC-RFPWEZLHSA-N

SMILES: F[C@@]12[C@]([C@]3([C@](C)(C[C@@H]1O)[C@@H](C(CO)=O)[C@H](C)C3)[H])(C[C@H](F)C=4[C@]2(C)C=CC(=O)C4)[H]

Synonyms:

• (6Alpha,11Beta,16Alpha)-6,9-Difluoro-11,21-Dihydroxy-16-Methylpregna-1,4-Diene-3,20-Dione
• (6Alpha,8Xi,10Xi,13Xi,14Xi,16Alpha,17Xi)-6,9-Difluoro-11,21-Dihydroxy-16-Methylpregna-1,4-Diene-3,20-Dione
• (6α,11β,16α)-6,9-Difluoro-11,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione
• 6alpha,9-Difluoro-11beta,21-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione
• 6α,9-Difluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione
• Diflucortolona
• Diflucortolona [INN-Spanish]
• Diflucortolone [USAN:INN:BAN]
• Diflucortolonum
• Diflucortolonum [INN-Latin]
• Difluocortolone
• Pregna-1,4-diene-3,20-dione, 6,9-difluoro-11,21-dihydroxy-16-methyl-, (6alpha,11beta,16alpha)-
• Pregna-1,4-diene-3,20-dione, 6,9-difluoro-11,21-dihydroxy-16-methyl-, (6α,11β,16α)-
• Pregna-1,4-diene-3,20-dione, 6α,9-difluoro-11β,21-dihydroxy-16α-methyl-
• Unii-K253365Dxi

Diflucortolone

CAS: 2607-06-9

Formula: C₂₂H₂₈F₂O₄

Color and Shape: White To Off-White Solid

Molecular weight: 394.46

Ref: 4Z-F-071007

Difluocortolone

Controlled Product

CAS: 2607-06-9

Applications Difluocortolone is used as a topical therapy in the treatment of pediatric tinea corporis; a common mycotic infection in children.
References Veraldi, S., et al.: J. Dermatol. Treat., 29, 200 (2018)

Formula: C₂₂H₂₈F₂O₄

Color and Shape: Neat

Molecular weight: 394.45

Ref: TR-D447019

Diflucortolone

Controlled Product

CAS: 2607-06-9

Corticosteroid used in topical dermatological treatments

Formula: C₂₂H₂₈F₂O₄

Purity: Min. 95 Area-%

Color and Shape: Powder

Molecular weight: 394.45 g/mol

Ref: 3D-FD41832

Diflucortolone

CAS: 2607-06-9

Formula: C₂₂H₂₈F₂O₄

Molecular weight: 394.46

Ref: ST-EA-CP-D115000