CAS 260779-88-2

Cisapride monohydrate

Description:

Cisapride monohydrate is a pharmaceutical compound primarily used as a prokinetic agent to enhance gastrointestinal motility. It belongs to the class of substituted benzamides and acts as a selective serotonin 5-HT4 receptor agonist, promoting the release of acetylcholine in the gastrointestinal tract. This action facilitates gastric emptying and improves esophageal motility, making it beneficial for conditions like gastroesophageal reflux disease (GERD) and functional dyspepsia. The monohydrate form indicates that the compound contains one molecule of water per molecule of cisapride, which can influence its solubility and stability. Cisapride has a relatively low solubility in water, which can affect its bioavailability. However, it is important to note that cisapride has been associated with serious cardiac side effects, leading to its withdrawal from the market in many countries. As a result, its use is now limited and closely monitored in clinical settings. Overall, cisapride monohydrate is characterized by its pharmacological properties, structural features, and safety profile, which are critical for its application in medical treatments.

Formula: C₂₃H₂₉ClFN₃O₄·H₂O

InChI: InChI=1/C23H29ClFN3O4.H2O/c1-30-21-13-19(26)18(24)12-17(21)23(29)27-20-8-10-28(14-22(20)31-2)9-3-11-32-16-6-4-15(25)5-7-16;/h4-7,12-13,20,22H,3,8-11,14,26H2,1-2H3,(H,27,29);1H2/t20-,22+;/s2

InChI key: InChIKey=QBYYXIDJOFZORM-IQBRHYPJNA-N

SMILES: C(N[C@H]1[C@@H](OC)CN(CCCOC2=CC=C(F)C=C2)CC1)(=O)C3=C(OC)C=C(N)C(Cl)=C3.O

Synonyms:

• Benzamide, 4-amino-5-chloro-N-[(3R,4S)-1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxy-, monohydrate, rel-
• Cisapride monohydrate
• Benzamide, 4-amino-5-chloro-N-[(3R,4S)-1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxy-, hydrate (1:1), rel-

Cisapride Monohydrate

CAS: 260779-88-2, 81098-60-4

Formula: C₂₃H₂₉ClFN₃O₄·H₂O

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 483.97

Ref: 3B-C3861

Cisapride

CAS: 260779-88-2

Compounds containing an unfused pyridine ring in the structure, nesoi

Formula: C₂₃H₂₉ClFN₃O₄·H₂O

Color and Shape: White Off-White Powder

Molecular weight: 483.19363

Ref: 45-1134120

Benzamide, 4-amino-5-chloro-N-[(3R,4S)-1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxy-, hydrate (1:1), rel-

CAS: 260779-88-2

Formula: C₂₃H₃₁ClFN₃O₅

Purity: 99%

Molecular weight: 483.9607

Ref: IN-DA002RLL

Cisapride monohydrate

CAS: 260779-88-2

Formula: C₂₃H₂₉N₃O₄ClF·H₂O

Purity: ≥ 98.0% (dried basis)

Color and Shape: White to off-white powder

Molecular weight: 483.96

Ref: 7W-GL0434

Cisapride hydrate

CAS: 260779-88-2

Cisapride acts directly as a selective agonist of serotonin 5-HT4 receptor with IC50 value of 0.483 μM. And It also acts indirectly as a parasympathomimetic.

Formula: C₂₃H₃₁ClFN₃O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 483.96

Ref: TM-T22296

Cisapride monohydrate

Controlled Product

CAS: 260779-88-2

Serotonin receptor (5-HT4) agonist

Formula: C₂₃H₂₉ClFN₃O₄·H₂O

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 483.96 g/mol

Ref: 3D-FC45139

Cisapride monohydrate - Bio-X ™

Controlled Product

CAS: 260779-88-2

Cisapride is a type of drug that is used for the treatment of heartburn associated with gastroesophageal reflux disease. This drug acts as a serotonin 5-HT4 receptor agonist that promotes the release of acetylcholine neurotransmitters. This results in a relaxation of the pyloric sphincter and an increase in gastric emptying.

Formula: C₂₃H₂₉ClFN₃O₄•H₂O

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 483.96 g/mol

Ref: 3D-BC164313