CAS 26095-59-0

Otilonium bromide

Description:

Otilonium bromide is a synthetic quaternary ammonium compound primarily used as an antispasmodic agent. It is characterized by its ability to relax smooth muscle, making it effective in treating gastrointestinal disorders, particularly those involving spasms, such as irritable bowel syndrome. The compound functions by blocking calcium channels, which helps to alleviate muscle contractions. Otilonium bromide is typically administered in oral form and is known for its relatively low side effect profile compared to other antispasmodics. Its solubility in water is moderate, and it is often formulated with other excipients to enhance its stability and bioavailability. The substance is generally well-tolerated, but like all medications, it may cause adverse effects in some individuals, including dry mouth or dizziness. As with any pharmaceutical, its use should be guided by a healthcare professional, considering the patient's specific medical history and condition. Overall, Otilonium bromide represents a valuable option in the management of gastrointestinal motility disorders.

Formula: C₂₉H₄₃N₂O₄·Br

InChI: InChI=1S/C29H42N2O4.BrH/c1-5-8-9-10-11-14-22-34-27-16-13-12-15-26(27)28(32)30-25-19-17-24(18-20-25)29(33)35-23-21-31(4,6-2)7-3;/h12-13,15-20H,5-11,14,21-23H2,1-4H3;1H

InChI key: InChIKey=VWZPIJGXYWHBOW-UHFFFAOYSA-N

SMILES: O(CCCCCCCC)C1=C(C(NC2=CC=C(C(OCC[N+](CC)(CC)C)=O)C=C2)=O)C=CC=C1.[Br-]

Synonyms:

• 247-457-4
• Ammonium, diethyl(2-hydroxyethyl)methyl-, bromide, p-[o-(octyloxy)benzamido]benzoate
• Benzoic acid, p-[o-(octyloxy)benzamido]-, ester with diethyl(2-hydroxyethyl)methylammonium bromide
• Ethanaminium, N,N-diethyl-N-methyl-2-[[4-[[2-(octyloxy)benzoyl]amino]benzoyl]oxy]-, bromide
• Ethanaminium, N,N-diethyl-N-methyl-2-[[4-[[2-(octyloxy)benzoyl]amino]benzoyl]oxy]-, bromide (1:1)
• N,N-Diethyl-N-methyl-2-[(4-{[2-(octyloxy)benzoyl]amino}benzoyl)oxy]ethanaminium bromide
• N,N-diethyl-2-[(4-{[2-(heptyloxy)benzoyl]amino}benzoyl)oxy]-N-methylethanaminium bromide
• Octylonium bromide
• Sp 63
• Spasmomen
• Otilonium bromide

Ethanaminium, N,N-diethyl-N-methyl-2-[[4-[[2-(octyloxy)benzoyl]amino]benzoyl]oxy]-, bromide (1:1)

CAS: 26095-59-0

Formula: C₂₉H₄₃BrN₂O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 563.5667

Ref: IN-DA002RN5

Otilonium bromide

CAS: 26095-59-0

Otilonium bromide (SP63) , an antimuscarinic, is utilized as a spasmolytic agent.

Formula: C₂₉H₄₃BrN₂O₄

Purity: 98.88% - 99.78%

Color and Shape: White Power

Molecular weight: 563.57

Ref: TM-T1474

Otilonium-d4 Bromide

CAS: 26095-59-0

Formula: C₂₉H₃₉D₄N₂O₄·Br

Color and Shape: White To Off-White Solid

Molecular weight: 487.70 79.90

Ref: 4Z-O-232

N,N-Diethyl-N-Methyl-2-((4-(2-(Octyloxy)Benzamido)Benzoyl)Oxy)Ethanaminium Bromide

CAS: 26095-59-0

N,N-Diethyl-N-Methyl-2-((4-(2-(Octyloxy)Benzamido)Benzoyl)Oxy)Ethanaminium Bromide

Purity: 98%

Molecular weight: 563.57g/mol

Ref: 54-OR1027064

Octylonium bromide

CAS: 26095-59-0

Formula: C₂₉H₄₃BrN₂O₄

Purity: ≥ 98.0%

Color and Shape: White to off-white or beige powder

Molecular weight: 563.57

Ref: 7W-GX7471

Otilonium bromide

CAS: 26095-59-0

Otilonium bromide

Purity: ≥98%

Molecular weight: 563.57g/mol

Ref: 54-BUP17024

Otilonium Bromide

CAS: 26095-59-0

Formula: C₂₉H₄₃N₂O₄·Br

Color and Shape: White To Off-White Solid

Molecular weight: 483.67 79.90

Ref: 4Z-O-231

Octylonium Bromide

CAS: 26095-59-0

Formula: C₂₉H₄₃N₂O₄·Br

Color and Shape: White Off-White

Molecular weight: 563.57

Ref: TR-O293250

Octylonium-d3 Bromide

Controlled Product

CAS: 26095-59-0

Applications Labelled Octylonium Bromide (O293250). Octylonium bromide is an antimuscarinic. Octylonium bromide is a platelet-activating factor antagonist as analgesic, anti-inflammatory, uterine contraction inhibiting, and anti-tumor agent. Octylonium bromide is used as an antispasmodic.
References Manzini, S., et al.: Drugs Exp. Clin. Res., 14, 265 (1988), Emonds-Alt, X., et al.: Eur. J. Pharmacol., 250, 403 (1993), Sutton, J., et al.: Eur. J. Clin. Pharmacol., 52, 365 (1997), Catalioto, R., et al.: Br. J. Pharmacol., 123, 81 (1998),

Formula: C₂₉H₄₀D₃BrN₂O₄

Color and Shape: Neat

Molecular weight: 566.59

Ref: TR-O293252

Octylonium bromide

CAS: 26095-59-0

Octylonium bromide is an otilonium-based compound that has been shown to be effective in the treatment of bowel disease. Octylonium bromide inhibits inflammatory and non-inflammatory bowel disease by inhibiting the production of proinflammatory cytokines, such as tumor necrosis factor alpha (TNFα), IL-1β, IL-6, and IL-8. Octylonium bromide also controls the signal pathways involved in the release of these cytokines. Octylonium bromide has been shown to have a statistically significant effect on diabetic neuropathy and urinary incontinence. This drug is absorbed through the stomach and small intestine into the blood stream. It then enters cells where it binds to specific sites on receptors, such as the neurokinin-1 receptor (NK1R). The NK1R is found in many different tissues throughout the body, including in smooth muscle cells of the bladder wall (detrusor muscle) and sensory neurons in peripheral

Formula: C₂₉H₄₃BrN₂O₄

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 563.57 g/mol

Ref: 3D-FO26526

OTILONIUM BROMIDE

CAS: 26095-59-0

Purity: 98%+(HPLC);RG

Molecular weight: 563.5770264

Ref: 10-F813428