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CAS 2611-61-2

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Thiamphenicol glycinate hydrochloride

Description:
Thiamphenicol glycinate hydrochloride is a synthetic antibiotic that belongs to the class of phenicol antibiotics. It is derived from thiamphenicol, which is known for its broad-spectrum antibacterial activity against both Gram-positive and Gram-negative bacteria. The compound is characterized by its solubility in water, which facilitates its use in various pharmaceutical formulations. Thiamphenicol glycinate hydrochloride is often utilized in veterinary medicine and has applications in treating infections in livestock and pets. Its mechanism of action involves inhibiting bacterial protein synthesis by binding to the 50S ribosomal subunit, similar to other antibiotics in the phenicol class. The hydrochloride form enhances its stability and bioavailability. Safety and efficacy are critical considerations in its use, and it is essential to adhere to recommended dosages to minimize the risk of adverse effects, including potential bone marrow suppression. As with any antibiotic, the development of resistance is a concern, necessitating careful monitoring and responsible use in clinical settings.
Formula:C14H18Cl2N2O6S·ClH
InChI:InChI=1S/C14H18Cl2N2O6S.ClH/c1-25(22,23)9-4-2-8(3-5-9)12(20)10(7-24-11(19)6-17)18-14(21)13(15)16;/h2-5,10,12-13,20H,6-7,17H2,1H3,(H,18,21);1H/t10-,12-;/m1./s1
InChI key:InChIKey=DKXJDBJNAXSJDH-MHDYBILJSA-N
SMILES:[C@@H]([C@H](O)C1=CC=C(S(C)(=O)=O)C=C1)(NC(C(Cl)Cl)=O)COC(CN)=O.Cl
Synonyms:
  • (2R,3R)-2-[(dichloroacetyl)amino]-3-hydroxy-3-[4-(methylsulfonyl)phenyl]propyl glycinate hydrochloride (1:1)
  • (2S,3R)-2-[(dichloroacetyl)amino]-3-hydroxy-3-[4-(methylsulfonyl)phenyl]propyl glycinate hydrochloride
  • 2-((Dichloroacetyl)amino)-3-hydroxy-3-(4-(methylsulphonyl)phenyl)propyl (R-(R*,R*))aminoacetate monohydrochloride
  • Glycine, (2R,3R)-2-[(2,2-dichloroacetyl)amino]-3-hydroxy-3-[4-(methylsulfonyl)phenyl]propyl ester, hydrochloride (1:1)
  • Glycine, (2R,3R)-2-[(dichloroacetyl)amino]-3-hydroxy-3-[4-(methylsulfonyl)phenyl]propyl ester, monohydrochloride
  • Glycine, 2-[(dichloroacetyl)amino]-3-hydroxy-3-[4-(methylsulfonyl)phenyl]propyl ester, monohydrochloride, [R-(R*,R*)]-
  • Glycine, alpha-ester with D-threo-(+)-2,2-dichloro-N-(beta-hydroxy-alpha-(hydroxymethyl)-p-(methylsulfonyl)phenethyl)acetamide, hydrochloride
  • Glycine, α-ester with 2,2-dichloro-N-[β-hydroxy-α-(hydroxymethyl)-p-(methylsulfonyl)phenethyl]acetamide, monohydrochloride, <span class="text-smallcaps">D</span>-threo-(+)-
  • Glycine, α-ester with <span class="text-smallcaps">D</span>-threo-(+)-2,2-dichloro-N-[β-hydroxy-α-(hydroxymethyl)-p-(methylsulfonyl)phenethyl]acetamide, monohydrochloride
  • Neomyson G
  • See more synonyms
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