CAS 26116-56-3

Erythromycylamine

Description:

Erythromycylamine, identified by its CAS number 26116-56-3, is a derivative of erythromycin, a macrolide antibiotic. This compound exhibits antibacterial properties, primarily effective against a range of Gram-positive bacteria and some Gram-negative organisms. Erythromycylamine functions by inhibiting bacterial protein synthesis, thereby preventing bacterial growth and replication. Its structure features a macrolide backbone, which is characteristic of erythromycin, modified to include an amine group that enhances its pharmacological profile. The compound is typically administered in clinical settings for treating various infections, particularly respiratory tract infections, skin infections, and certain sexually transmitted diseases. Erythromycylamine may also exhibit anti-inflammatory properties, making it a candidate for research in treating inflammatory conditions. However, like other antibiotics, its use must be carefully managed to prevent the development of antibiotic resistance. Safety and efficacy profiles are established through clinical studies, and potential side effects may include gastrointestinal disturbances and allergic reactions. Overall, erythromycylamine represents a significant advancement in antibiotic therapy, contributing to the arsenal against bacterial infections.

Formula: C₃₇H₇₀N₂O₁₂

InChI: InChI=1S/C37H70N2O12/c1-14-25-37(10,45)30(41)20(4)27(38)18(2)16-35(8,44)32(51-34-28(40)24(39(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(9,46-13)31(42)23(7)48-26/h18-32,34,40-42,44-45H,14-17,38H2,1-13H3/t18-,19-,20+,21+,22-,23+,24+,25-,26+,27+,28-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1

InChI key: InChIKey=XCLJRCAJSCMIND-JCTYMORFSA-N

SMILES: O([C@@H]1[C@@H](C)[C@H](O[C@H]2C[C@](OC)(C)[C@@H](O)[C@H](C)O2)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)[C@@H](N)[C@H](C)C[C@@]1(C)O)[C@H]3[C@H](O)[C@@H](N(C)C)C[C@@H](C)O3

Synonyms:

• (3R,4S,5S,6R,7R,9R,10S,11S,12R,13S,14R)-10-amino-6-(((3S,4S,6S)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-14-ethyl-7,12,13-trihydroxy-4-(((4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-3,5,7,9,11,13-hexamethyloxacyclotetradecan-2-oneErythromycylamine
• (3R,4S,5S,6R,7R,9R,10S,11S,12R,13S,14R)-10-amino-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-14-ethyl-7,12,13-trihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-3,5,7,9,11,13-hexamethyloxacyclotetradecan-2-one (non-preferred name)
• (9S)-9-Amino-9-deoxoerythromycin
• (9S)-9-Deoxy-9-aminoerythromycin A
• (9S)-Erythromycylamine A
• 9(S)-Erythromycylamine
• 9-Amino-9-deoxo-erythromycin, stereoisomer
• 9-Epierythromycylamine
• Brl 42852Er
• Brn 4241492
• Epierythromycyl-A-amine
• Erythromycin, 9-amino-9-deoxo-, (9S)-
• Erythromycin, 9-amino-9-deoxo-, stereoisomer
• Erythromycylamine
• Ly 024410

(9S)-9-Amino-9-deoxoerythromycin

CAS: 26116-56-3

Formula: C₃₇H₇₀N₂O₁₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 734.9579

Ref: IN-DA00C350

Erythromycylamine (Dirithromycin EP Impurity A)

CAS: 26116-56-3

Formula: C₃₇H₇₀N₂O₁₂

Molecular weight: 734.97

Ref: 4Z-E-204

Erythromycylamine

CAS: 26116-56-3

Erythromycylamine

Purity: 97%

Molecular weight: 734.96g/mol

Ref: 54-OR1007171

Erythromycylamine-13C-d3 (Dirithromycin EP Impurity A-13C-d3)

CAS: 26116-56-3

Formula: CC₃₆H₆₇D₃N₂O₁₂

Color and Shape: White To Off-White Solid

Molecular weight: 738.98

Ref: 4Z-E-205

Erythromycylamine

CAS: 26116-56-3

Formula: C₃₇H₇₀N₂O₁₂

Purity: >90.0%(qNMR)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 734.97

Ref: 3B-E1555

Erythromycylamine-d3

Controlled Product

CAS: 26116-56-3

Stability Hygroscopic
Applications Erythromycylamine-d3 is labelled Erythromycylamine (E653400) which is a metabolite of Dirithromycin (D493000). It is also a potent macrolide antibiotic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Bauldry, S., et al.: J. Biol. Chem., 263, 16787 (1988); Labro, M., et al.: J. Antimicrob. Chemother., 24, 561 (1989); Dumas, R., et al.: Chemother., 36, 381 (1990); Bacci, P., et al.: J. Chemother., 4, 268 (1992); Montenez, J., et al.: Toxicol. Appl. Pharmacol., 156, 129 (1999)

Formula: C₃₇H₆₇D₃N₂O₁₂

Color and Shape: Neat

Molecular weight: 737.98

Ref: TR-E653402

Erythromycylamine

CAS: 26116-56-3

Erythromycylamine is a semisynthetic antibiotic, which is derived from the parent compound erythromycin. This compound is sourced from the fermentation product of the bacterium *Saccharopolyspora erythraea*. Erythromycylamine acts by inhibiting bacterial protein synthesis, specifically targeting the 50S ribosomal subunit, which ultimately leads to the disruption of bacterial cell growth and replication.

Formula: C₃₇H₇₀N₂O₁₂

Purity: Min. 95%

Molecular weight: 734.96 g/mol

Ref: 3D-AE22802

Dirithromycin EP Impurity A

CAS: 26116-56-3

Formula: C₃₇H₇₀N₂O₁₂

Molecular weight: 735

Ref: ST-EA-CP-D168001

Erythromycylamine

CAS: 26116-56-3

Erythromycylamine is a useful organic compound for research related to life sciences. The catalog number is T64443 and the CAS number is 26116-56-3.

Formula: C₃₇H₇₀N₂O₁₂

Color and Shape: Solid

Molecular weight: 734.969

Ref: TM-T64443

Dirithromycin EP Impurity A (Erythromycylamine)

CAS: 26116-56-3

Formula: C₃₇H₇₀N₂O₁₂

Color and Shape: White To Off-White Solid

Molecular weight: 734.98

Ref: 4Z-D-106005