CAS 26159-35-3

(+)-Naproxen methyl ester

Description:

(+)-Naproxen methyl ester, with the CAS number 26159-35-3, is an ester derivative of naproxen, a nonsteroidal anti-inflammatory drug (NSAID) commonly used for its analgesic and anti-inflammatory properties. This compound typically appears as a white to off-white crystalline solid and is characterized by its moderate solubility in organic solvents like ethanol and methanol, while being less soluble in water. The chemical structure features a naphthalene ring system, which contributes to its biological activity, and a methyl ester functional group that influences its pharmacokinetics. (+)-Naproxen methyl ester is often studied for its potential therapeutic applications and as an intermediate in the synthesis of other pharmaceutical compounds. Its stereochemistry, indicated by the (+) designation, suggests that it possesses specific optical activity, which can affect its interaction with biological targets. As with many esters, it may undergo hydrolysis in the presence of water or enzymes, leading to the release of naproxen and methanol.

Formula: C₁₅H₁₆O₃

InChI: InChI=1S/C15H16O3/c1-10(15(16)18-3)11-4-5-13-9-14(17-2)7-6-12(13)8-11/h4-10H,1-3H3/t10-/m0/s1

InChI key: InChIKey=ZFYFBPCRUQZGJE-JTQLQIEISA-N

SMILES: [C@H](C(OC)=O)(C)C1=CC2=C(C=C(OC)C=C2)C=C1

Synonyms:

• Naproxen methyl ester
• (+)-Naproxen methyl ester
• 2-Naphthaleneacetic acid, 6-methoxy-α-methyl-, methyl ester, (αS)-
• (S)-Naproxen methyl ester
• 2-Naphthaleneacetic acid, 6-methoxy-α-methyl-, methyl ester, (S)-
• Naproxen EP Impurity E/(S)-Naproxen Methyl- Ester
• (S)-α-Methyl-6-methoxy-2-naphthaleneacetic acid methyl ester
• Naproxen Sodium impurity E Q: What are the applications of
• (S)-6-Methoxy-α-methyl-2-naphthaleneacetic acid methyl ester
• Naproxen EP IMpurity E
• Methyl (2S)-2-(6-Methoxynaphthalen-
• Naproxen Sodium impurity EQ: What is
• Naproxen Impurity E
• Naproxen Sodium impurity E Q: What is the storage condition of
• Methyl (S)-2-(6-Methoxynaphthalen-2-yl)
• Methyl-2-(6-methoxy-2-naphthyl) propionate
• Naproxen Impurity 5（Naproxen EP Impurity E）
• Naproxen Sodium impurity E Q: What is the CAS Number of
• Naproxen methyl
• Naproxen Sodium impurity E
• Naproxen Sodium EP Impurity E
• (S)-α-Methyl-6-methoxynaphthalene-2-acetic acid methyl ester
• propanoate
• (S)-Naproxen methyl

Naproxen Related Compound E ((S)-Methyl 2-(6-methoxynaphthalen-2-yl)propanoate)

CAS: 26159-35-3

Carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides etc, nesoi

Formula: C₁₅H₁₆O₃

Color and Shape: White Crystalline Powder

Molecular weight: 244.10994

Ref: 45-1457356

2-Naphthaleneacetic acid, 6-methoxy-α-methyl-, methyl ester, (αS)-

CAS: 26159-35-3

Formula: C₁₅H₁₆O₃

Purity: 95%

Color and Shape: Solid

Molecular weight: 244.2857

Ref: IN-DA002RX8

Naproxen EP Impurity E (Naproxen USP Related Compound E)

CAS: 26159-35-3

Formula: C₁₅H₁₆O₃

Color and Shape: White To Off-White Solid

Molecular weight: 244.29

Ref: 4Z-N-2310

(S)-Methyl 2-(6-methoxynaphthalen-2-yl)propanoate

CAS: 26159-35-3

(S)-Methyl 2-(6-methoxynaphthalen-2-yl)propanoate

Purity: 95%

Molecular weight: 244.29g/mol

Ref: 54-OR1073511

Methyl (2S)-2-(6-Methoxynaphthalen-2-yl)propanoate (Naproxen Methyl Ester)

Controlled Product

CAS: 26159-35-3

Formula: C₁₅H₁₆O₃

Color and Shape: Neat

Molecular weight: 244.29

Ref: 86-MM0152.02

(S)-Naproxen Methyl Ester

CAS: 26159-35-3

Impurity Naproxen EP Impurity E
Applications Naproxen (N377520) methyl derivative. Naproxen impurity. Naproxen is a non-steroidal anti-inflammatory drug (NSAID) indicated for the treatment of pain, inflammatory conditions such as rheumatoid arthritis, and fever. The drug belongs to the 2-aryl propionic acid family of COX-1 and COX-2 inhibitors.
References Haddock, R., et al.: Xenobiotica, 14, 327 (1984), Jeremy, J., et al.: Drugs, 40, 53 (1990), Wadhwa, L., et al.: Int. J. Pharm., 118, 31 (1995),

Formula: C₁₅H₁₆O₃

Color and Shape: Neat

Molecular weight: 244.29

Ref: TR-N377550

Naproxen EP Impurity E

CAS: 26159-35-3

Formula: C₁₅H₁₆O₃

Molecular weight: 244.29

Ref: ST-EA-CP-N2005

(S)-Naproxen methyl ester

CAS: 26159-35-3

(S)-Naproxen methyl ester is a nonsteroidal anti-inflammatory drug that is used to treat pain and inflammation. It inhibits the production of prostaglandins by inhibiting cyclooxygenase (COX) activity, which converts arachidonic acid into prostaglandins. The enzyme COX is responsible for the formation of various inflammatory mediators such as prostaglandins and thromboxanes. Naproxen has no effect on platelet aggregation or blood coagulation time, and has low potential for serious side effects. Naproxen was synthesized in an enantioselective fashion by employing kinetic resolution strategies with asymmetric synthesis. This strategy allowed the preparation of a single enantiomer of naproxen, which may have different pharmacological properties than its racemic counterpart.

Formula: C₁₅H₁₆O₃

Purity: Min. 95%

Molecular weight: 244.29 g/mol

Ref: 3D-FN26159