CAS 2627-62-5

2'-chloro-2'-deoxyadenosine

Description:

2'-Chloro-2'-deoxyadenosine (CAS number 2627-62-5) is a synthetic nucleoside analog of adenosine, characterized by the presence of a chlorine atom at the 2' position of the deoxyribose sugar. This modification alters its biological properties, making it of interest in medicinal chemistry, particularly in the development of antiviral and anticancer agents. The compound exhibits a purine base structure, specifically adenine, linked to a deoxyribose sugar, which is essential for its function in nucleic acid synthesis. Its mechanism of action often involves interference with DNA synthesis, leading to cytotoxic effects in rapidly dividing cells. 2'-Chloro-2'-deoxyadenosine is soluble in water and exhibits stability under physiological conditions, although it may be subject to enzymatic degradation. The compound's pharmacological profile includes potential immunosuppressive effects, making it relevant in the context of treating certain diseases. Overall, its unique structural features contribute to its utility in various therapeutic applications, particularly in oncology and virology.

Formula: C₁₀H₁₂ClN₅O₃

InChI: InChI=1/C10H12ClN5O3/c11-5-7(18)4(1-17)19-10(5)16-3-15-6-8(12)13-2-14-9(6)16/h2-5,7,10,17-18H,1H2,(H2,12,13,14)/t4-,5-,7-,10-/m1/s1

InChI key: InChIKey=ADXUXRNLBYKGOA-QYYRPYCUSA-N

SMILES: Cl[C@H]1[C@H](N2C=3C(N=C2)=C(N)N=CN3)O[C@H](CO)[C@H]1O

Synonyms:

• NSC 289354
• 2′-Chloro-2′-deoxyadenosine
• Adenosine, 2′-chloro-2′-deoxy-
• 2′-Deoxy-2′-chloroadenosine
• [Synonyms]

2’-Chloro-2’-deoxyadenosine

CAS: 2627-62-5

Formula: C₁₀H₁₂ClN₅O₃

Purity: 95%

Molecular weight: 285.687

Ref: IN-DA002SJG

2'-Chloro-2'-deoxyadenosine

CAS: 2627-62-5

2'-Chloro-2'-deoxyadenosine is a Nucleoside Derivative - Halo-nucleoside; 2'-Modified nucleoside.

Formula: C₁₀H₁₂ClN₅O₃

Color and Shape: Solid

Molecular weight: 285.69

Ref: TM-TNU0306

2’-Chloro-2’-deoxyadenosine

CAS: 2627-62-5

2’-Chloro-2’-deoxyadenosine (2CDA) is a synthetic nucleoside analogue that is used as an antineoplastic agent for the treatment of non-Hodgkin lymphoma and histiocytic lymphoma. It is typically used in combination with other cytotoxic drugs. 2CDA has been shown to be effective against resistant tumor cell lines and has been used to treat patients with metastatic breast cancer, Hodgkin lymphoma, and multiple myeloma. The drug can cause thrombocytopenia, which may be due to its effects on platelets or bone marrow cells. Other toxicities include bone marrow suppression, nausea, vomiting, diarrhea, anorexia, and liver damage. Patients who are at risk for these toxicities should be closely monitored.

Formula: C₁₀H₁₂ClN₅O₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 285.69 g/mol

Ref: 3D-NC144452