CAS 26305-03-3: pepstatin A ~120'000 U/mg
Description:Pepstatin A is a potent and selective inhibitor of aspartic proteases, particularly renin and pepsin, and is derived from the fermentation of certain species of the bacterium *Streptomyces*. It is characterized by its unique structure, which includes a peptide backbone with a specific sequence that allows it to effectively bind to the active sites of target enzymes, thereby inhibiting their activity. The substance has a molecular weight of approximately 1,000 Da and is often used in biochemical research to study proteolytic processes and enzyme kinetics. Pepstatin A exhibits high specificity and affinity for aspartic proteases, making it a valuable tool in both basic and applied research, including studies related to protein digestion and regulation. Its effectiveness is often quantified in units of inhibition, such as "120,000 U/mg," indicating its potency. Additionally, it is important to handle pepstatin A with care, as it can have biological effects, and proper storage conditions are necessary to maintain its stability and activity.
Formula:C34H63N5O9
InChI:InChI=1/C34H63N5O9/c1-17(2)12-23(37-33(47)31(21(9)10)39-34(48)30(20(7)8)38-27(42)14-19(5)6)25(40)15-28(43)35-22(11)32(46)36-24(13-18(3)4)26(41)16-29(44)45/h17-26,30-31,40-41H,12-16H2,1-11H3,(H,35,43)(H,36,46)(H,37,47)(H,38,42)(H,39,48)(H,44,45)/t22-,23+,24-,25-,26+,30-,31-/m1/s1
- Synonyms:
- Pepstatin A
- pepstatin A from microbial source
- Pepstatin (microbial product)
- Isovaleryl-Val-Val-Sta-Ala-Sta-OH
- N-(3-methylbutanoyl)-L-valyl-N-[(1S,2S)-4-{[(1S)-2-({(1S)-1-[(1S)-2-carboxy-1-hydroxyethyl]-3-methylbutyl}amino)-1-methyl-2-oxoethyl]amino}-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]-L-valinamide
- (3S,4R)-3-hydroxy-4-[[(2R)-2-[[(3R,4S)-3-hydroxy-6-methyl-4-[[(2R)-3-methyl-2-[[(2R)-3-methyl-2-(3-methylbutanoylamino)butanoyl]amino]butanoyl]amino]heptanoyl]amino]propanoyl]amino]-6-methyl-heptanoic acid
- Pepstatin
