CAS 26305-03-3

pepstatin A ~120'000 U/mg

Description:

Pepstatin A is a potent and selective inhibitor of aspartic proteases, particularly renin and pepsin, and is derived from the fermentation of certain species of the bacterium *Streptomyces*. It is characterized by its unique structure, which includes a peptide backbone with a specific sequence that allows it to effectively bind to the active sites of target enzymes, thereby inhibiting their activity. The substance has a molecular weight of approximately 1,000 Da and is often used in biochemical research to study proteolytic processes and enzyme kinetics. Pepstatin A exhibits high specificity and affinity for aspartic proteases, making it a valuable tool in both basic and applied research, including studies related to protein digestion and regulation. Its effectiveness is often quantified in units of inhibition, such as "120,000 U/mg," indicating its potency. Additionally, it is important to handle pepstatin A with care, as it can have biological effects, and proper storage conditions are necessary to maintain its stability and activity.

Formula: C₃₄H₆₃N₅O₉

InChI: InChI=1/C34H63N5O9/c1-17(2)12-23(37-33(47)31(21(9)10)39-34(48)30(20(7)8)38-27(42)14-19(5)6)25(40)15-28(43)35-22(11)32(46)36-24(13-18(3)4)26(41)16-29(44)45/h17-26,30-31,40-41H,12-16H2,1-11H3,(H,35,43)(H,36,46)(H,37,47)(H,38,42)(H,39,48)(H,44,45)/t22-,23+,24-,25-,26+,30-,31-/m1/s1

Synonyms:

• Pepstatin A
• pepstatin A from microbial source
• Pepstatin (microbial product)
• Isovaleryl-Val-Val-Sta-Ala-Sta-OH
• N-(3-methylbutanoyl)-L-valyl-N-[(1S,2S)-4-{[(1S)-2-({(1S)-1-[(1S)-2-carboxy-1-hydroxyethyl]-3-methylbutyl}amino)-1-methyl-2-oxoethyl]amino}-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]-L-valinamide
• (3S,4R)-3-hydroxy-4-[[(2R)-2-[[(3R,4S)-3-hydroxy-6-methyl-4-[[(2R)-3-methyl-2-[[(2R)-3-methyl-2-(3-methylbutanoylamino)butanoyl]amino]butanoyl]amino]heptanoyl]amino]propanoyl]amino]-6-methyl-heptanoic acid
• Pepstatin

Pepstatin A

CAS: 26305-03-3

Pepstatin A (isovaleryl-pepstatin), a low molecular weight inhibitor of acid proteases, e.g. pepsin, renin, cathepsin D, and plasmepsin II. For the Plasmodium falciparum aspartyl protease plasmepsin II, Hill et al determined an IC₅₀ of 0.1 nM.

Formula: C₃₄H₆₃N₅O₉

Purity: > 99%

Color and Shape: White Powder

Molecular weight: 685.9

Ref: 01-4031136

Pepstatin

CAS: 26305-03-3

Pepstatin (Pepsin Inhibitor S 735A) is a specific and orally aspartate protease inhibitor that also inhibits HIV protease activity. Cost effective and quality assured.

Formula: C₃₄H₆₃N₅O₉

Purity: 96.74% - 99.94%

Color and Shape: Solid

Molecular weight: 685.89

Ref: TM-T3695

L-Alaninamide,N-(3-methyl-1-oxobutyl)-L-valyl-L-valyl-(3S,4S)-4-amino-3-hydroxy-6-methylheptanoyl-N-[(1S)-1-[(1S)-2-carboxy-1-hydroxyethyl]-3-methylbutyl]-

CAS: 26305-03-3

Formula: C₃₄H₆₃N₅O₉

Purity: 75%

Color and Shape: Solid

Molecular weight: 685.8921

Ref: IN-DA00I50B

Pepstatin A

CAS: 26305-03-3

Pepstatin A

Formula: C₃₄H₆₃N₅O₉

Purity: By hplc: 98.2% (220 nm) (Typical Value in Batch COA)

Color and Shape: white to off white powder

Molecular weight: 685.89212g/mol

Ref: 54-BIMI2205

Pepstatin

CAS: 26305-03-3

Pepstatin

Purity: ≥95%

Molecular weight: 685.89g/mol

Ref: 54-BUP16261

Pepstatin A

CAS: 26305-03-3

Formula: C₃₄H₆₃N₅O₉

Purity: >90.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 685.90

Ref: 3B-P3041

Pepstatin A

CAS: 26305-03-3

Formula: C₃₄H₆₃N₅O₉

Molecular weight: 685.90

Ref: 4Z-P-470001

Pepstatin A

CAS: 26305-03-3

Formula: C₃₄H₆₃N₅O₉

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 685.90

Ref: 7W-GE3524

Pepstatin A (Purity Higher than 90% by HPLC)

CAS: 26305-03-3

Pepstatin A is a natural product that inhibits the activity of proteases, particularly chymotrypsin and trypsin. It binds to the active site of these enzymes, blocking access to their substrate. Pepstatin A has been shown to have synergistic effects with other drugs in vitro, such as dapsone and clindamycin. Pepstatin A has inhibitory properties against infectious diseases, including HIV-1 and HIV-2, influenza virus type A (H1N1), herpes simplex virus type 1 (HSV-1), human papilloma virus type 18 (HPV-18), hepatitis C virus (HCV) types 1a and 1b, as well as dengue fever virus. Pepstatin A is also effective in inhibiting polymerase chain reaction amplification of mitochondrial DNA from patients with mitochondrial disorders. The biological sample for this research was obtained from calf thymus tissue. The natural compound pepstatin A has

Formula: C₃₄H₆₃N₅O₉

Purity: Higher Than 90% By Hplc)

Molecular weight: 685.89 g/mol

Ref: 3D-IPA-4397

Pepstatin A (Synthetic)

CAS: 26305-03-3

Pepstatin A is a natural product that has been synthesized for use as an inhibitor of proteolytic enzymes. It inhibits the activity of a wide range of proteases and is used in vitro to study the biochemical properties of these enzymes. Pepstatin A inhibits the activity of many important proteases, including those involved in infectious diseases, such as HIV and hepatitis C virus. Pepstatin A binds to the active site on serine proteases, blocking access by their substrates and thereby inhibiting enzyme activity. The binding site is highly conserved among different types of serine protease, with approximately 90% homology between trypsin and chymotrypsin. The inhibitory mechanism involves a specific interaction between pepstatin A's hydrophobic side chain and the catalytic triad residues His57, Asp102, and Ser195 in trypsin or His57, Asp102, and Ser188 in chymotrypsin.

Formula: C₃₄H₆₃N₅O₉

Purity: Min. 95%

Molecular weight: 685.89 g/mol

Ref: 3D-IPA-3998-PI

Pepstatin A

CAS: 26305-03-3

Pepstatin A was originally purified from Actinomycetes species. The peptide is unusual in containing the amino acid statine (4-amino-hydroxy-6-methylheptanoic acid also known as AMHA). Pepstatin A competitively binds with acid proteases in a highly selective reversible manner to inhibit protease activity. Pepstatin A is ineffective on thiol, neutral and serine proteases. The functions of proteases have been investigated by the application of pepstatin A such as renin, pepsin, bovine chymosin and retroviral proteases from HIV. Characterisation of HIV protease using pepstatin A has been vital in development of HIV treatment to block viral replication. Pepstatin A is also a reagent to disrupt autophagy- this helps characterise the function of proteosome degradation in research such as during influenza A replication and improving drug delivery of therapeutic cancer treatments.

Molecular weight: 685.89 g/mol

Ref: 3D-CRB1001649