CAS 26315-32-2

[(2S,5R)-5-(6-amino-9H-purin-9-yl)tetrahydrofuran-2-yl]methyl dihydrogen phosphate

Description:

The chemical substance known as [(2S,5R)-5-(6-amino-9H-purin-9-yl)tetrahydrofuran-2-yl]methyl dihydrogen phosphate, with the CAS number 26315-32-2, is a nucleotide analog that plays a significant role in biochemical processes. This compound features a tetrahydrofuran ring, which contributes to its structural rigidity and stereochemistry, specifically exhibiting a chiral center that influences its biological activity. The presence of the amino purine moiety suggests potential interactions with nucleic acid structures, making it relevant in the study of nucleic acid metabolism and signaling pathways. The dihydrogen phosphate group indicates that it can participate in phosphorylation reactions, which are crucial for energy transfer and signal transduction in cells. Additionally, the compound's solubility and stability in aqueous environments are important for its biological function. Overall, this substance is of interest in medicinal chemistry and biochemistry, particularly in the development of therapeutic agents targeting nucleic acid-related processes.

Formula: C₁₀H₁₂N₅O₅P

InChI: InChI=1/C10H14N5O5P/c11-9-8-10(13-4-12-9)15(5-14-8)7-2-1-6(20-7)3-19-21(16,17)18/h4-7H,1-3H2,(H2,11,12,13)(H2,16,17,18)/p-2/t6-,7+/m0/s1

Synonyms:

• [(2S,5R)-5-(6-Amino-9H-purin-9-yl)tetrahydrofuran-2-yl]methyl phosphate
• 2-furanmethanol, 5-(6-amino-9H-purin-9-yl)tetrahydro-, dihydrogen phosphate (ester), ion(2-), (2S,5R)-

2',3'-DIDEOXYADENOSINE 5'-PHOSPHONATE

CAS: 26315-32-2

Formula: C₁₀H₁₄N₅O₄P

Molecular weight: 299.2230

Ref: IN-DA002SOR

2',3'-Dideoxyadenosine-5'-monophosphate

CAS: 26315-32-2

2',3'-Dideoxyadenosine-5'-monophosphate (ddAMP) is an adenosine analog that is a substrate for the enzyme dideoxyribonucleoside kinase. It is activated by phosphorylation to the 5' ends of DNA molecules and inhibits viral replication. ddAMP has been shown to be effective in treating human immunodeficiency virus (HIV) infection, at least in part, by inhibiting the production of p24 antigen levels and reducing the number of CD4+ lymphocytes. The mechanism of action may involve binding to HIV-1 RNA, which prevents it from interacting with cellular dsDNA and inhibits its transcription into DNA.

Formula: C₁₀H₁₄N₅O₅P

Purity: Min. 95%

Molecular weight: 315.22 g/mol

Ref: 3D-ND30902