CAS 26328-04-1

Cinepazide maleate

Description:

Cinepazide maleate is a pharmaceutical compound primarily used as a vasodilator and for its neuroprotective properties. It is classified as a derivative of the benzodiazepine family and is known for its ability to improve blood flow, particularly in the cerebral circulation. The maleate salt form enhances its solubility and stability, making it suitable for various formulations. Cinepazide maleate exhibits a mechanism of action that involves the modulation of neurotransmitter release and the inhibition of platelet aggregation, contributing to its therapeutic effects. The compound is typically administered in clinical settings for conditions related to impaired cerebral circulation, such as stroke or cognitive disorders. Its safety profile includes common side effects like dizziness or gastrointestinal disturbances, but it is generally well-tolerated. As with any medication, it is essential to consider contraindications and interactions with other drugs. Overall, Cinepazide maleate represents a valuable option in the management of vascular and neurological conditions.

Formula: C₂₂H₃₁N₃O₅·C₄H₄O₄

InChI: InChI=1S/C22H31N3O5.C4H4O4/c1-28-18-14-17(15-19(29-2)22(18)30-3)6-7-20(26)25-12-10-23(11-13-25)16-21(27)24-8-4-5-9-24;5-3(6)1-2-4(7)8/h6-7,14-15H,4-5,8-13,16H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

InChI key: InChIKey=XSTJTOKYCAJVMJ-BTJKTKAUSA-N

SMILES: O(C)C1=C(OC)C(OC)=CC(C=CC(=O)N2CCN(CC(=O)N3CCCC3)CC2)=C1.C(=C\C(O)=O)\C(O)=O

Synonyms:

• (E)-1-[4-(2-oxo-2-pyrrolidin-1-yl-ethyl)piperazin-1-yl]-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
• (Z)-but-2-enedioate
• 1-((1-Pyrrolidinylcarbonyl)methyl)-4-(3,4,5-trimethoxycinnamoyl)piperazine maleate
• 1-(2-Oxo-2-(1-pyrrolidinyl)ethyl)-4-(1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl)piperazine (Z)-2-butenedioate (1:1)
• 1-(2-Oxo-2-pyrrolidin-1-ylethyl)-4-(3-(3,4,5-trimethoxyphenyl)acryloyl)piperazine monomaleate
• 1-(2-oxo-2-pyrrolidin-1-ylethyl)-4-[(2E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]piperazine (2Z)-but-2-enedioate
• 1-(2-oxo-2-pyrrolidin-1-ylethyl)-4-[3-(3,4,5-trimethoxyphenyl)acryloyl]piperazine (2Z)-but-2-enedioate
• 1-(4-((3',4',5'-Trimethoxycinnamoyl)-1-piperazinyl)acetyl)pyrrolidine maleate
• 2-Propen-1-one, 1-[4-[2-oxo-2-(1-pyrrolidinyl)ethyl]-1-piperazinyl]-3-(3,4,5-trimethoxyphenyl)-, (2Z)-2-butenedioate (1:1)
• 4-(3,4,5-Trimethoxycinnamoyl)-1-(1-pyrrolidinyl)carbonylmethylpiperazine maleate
• Brendil
• Maleate de cinepazide
• Maleate de cinepazide [French]
• Md 67350
• Nsc 291562
• Piperazine, 1-((1-pyrrolidinylcarbonyl)methyl)-4-(3',4',5'-trimethoxycinnamoyl)-, maleate
• Piperazine, 1-(2-oxo-2-(1-pyrrolidinyl)ethyl)-4-(1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl)-, (Z)-2-butenedioate (1:1) (9CI)
• Piperazine, 1-[(1-pyrrolidinylcarbonyl)methyl]-4-(3,4,5-trimethoxycinnamoyl)-, maleate (1:1)
• Piperazine, 1-[2-oxo-2-(1-pyrrolidinyl)ethyl]-4-[1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl]-, (2Z)-2-butenedioate (1:1)
• Piperazine, 1-[2-oxo-2-(1-pyrrolidinyl)ethyl]-4-[1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl]-, (Z)-2-butenedioate (1:1)
• Vasodistal

Cinepazide maleate

CAS: 26328-04-1

Cinepazide maleate (MD-67350), a maleate salt form of cinepazide, is a vasodilator.

Formula: C₂₂H₃₁N₃O₅·C₄H₄O₄

Purity: 99.9% - 99.97%

Color and Shape: White Or Off-White Crystalline Powder

Molecular weight: 533.57

Ref: TM-T0368

2-Propen-1-one, 1-[4-[2-oxo-2-(1-pyrrolidinyl)ethyl]-1-piperazinyl]-3-(3,4,5-trimethoxyphenyl)-, (2Z)-2-butenedioate (1:1)

CAS: 26328-04-1

Formula: C₂₆H₃₅N₃O₉

Purity: 99%

Color and Shape: Solid

Molecular weight: 533.5708

Ref: IN-DA002SR6

Cinepazide Maleate

CAS: 26328-04-1

Formula: C₂₂H₃₁N₃O₅·C₄H₄O₄

Color and Shape: White To Off-White Solid

Molecular weight: 417.51 116.07

Ref: 4Z-C-143001

Cinepazide maleate

CAS: 26328-04-1

Cinepazide maleate

Purity: ≥98%

Molecular weight: 533.57g/mol

Ref: 54-BUP13617

Cinepazide Maleate

CAS: 26328-04-1

Cinepazide Maleate

Purity: 99%

Molecular weight: 533.57g/mol

Ref: 54-OR1027425

Cinepazide Maleate

CAS: 23887-46-9, 26328-04-1

Formula: C₂₂H₃₁N₃O₅·C₄H₄O₄

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Light yellow to Light orange powder to crystal

Molecular weight: 533.58

Ref: 3B-C3474

Cinepazide Maleate

Controlled Product

CAS: 26328-04-1

Applications Cinepazide Maleate, is a vasodilator used in China for the treatment of cardiovascular and cerebrovascular diseases, and peripheral vascular diseases.It appears to work by potentiating A2 adenosine receptors.
References Ruffolo RR Jr., et al. : Drug receptors and control of the cardiovascular system: recent advances. Prog Drug Res. 1991;36:117-360.;

Formula: C₂₂H₃₁N₃O₅C₄H₄O₄

Color and Shape: Neat

Molecular weight: 417.22637

Ref: TR-C441963