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CAS 263351-82-2

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Paclitaxel poliglumex

Description:
Paclitaxel poliglumex, also known as CT-2103, is a polymeric formulation of the chemotherapeutic agent paclitaxel, designed to enhance its solubility and reduce toxicity. It is characterized by its conjugation to a polyglutamate chain, which facilitates improved delivery to cancer cells through enhanced cellular uptake. This modification allows for a more sustained release of paclitaxel, potentially leading to increased efficacy against various tumors, particularly in cases of solid tumors. The substance exhibits a mechanism of action similar to that of paclitaxel, primarily by stabilizing microtubules and inhibiting cell division. Paclitaxel poliglumex is typically administered intravenously and is being investigated for its effectiveness in treating several types of cancer, including breast and lung cancers. Its formulation aims to minimize the side effects commonly associated with traditional paclitaxel therapy, such as neuropathy and hypersensitivity reactions, while maintaining therapeutic activity. As with any chemotherapeutic agent, its use is accompanied by monitoring for potential adverse effects and interactions with other medications.
Formula:C47H51NO14·x(C5H9NO4)x
InChI:InChI=1S/C47H51NO14.C5H9NO4/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5;6-3(5(9)10)1-2-4(7)8/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54);3H,1-2,6H2,(H,7,8)(H,9,10)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+;3-/m00/s1
InChI key:InChIKey=ZPUHVPYXSITYDI-HEUWMMRCSA-N
SMILES:O(C(C)=O)[C@]12[C@]3([C@H](OC(=O)C4=CC=CC=C4)[C@@]5(O)C(C)(C)C([C@@H](OC(C)=O)C(=O)[C@]3(C)[C@@H](O)C[C@]1(OC2)[H])=C(C)[C@@H](OC([C@@H]([C@@H](NC(=O)C6=CC=CC=C6)C7=CC=CC=C7)O)=O)C5)[H].[C@H](CCC(O)=O)(C(O)=O)N
Synonyms:
  • CT 2103
  • PG-TXL
  • L-Glutamic acid, homopolymer, (1R,2S)-2-(benzoylamino)-1-[[[(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl]oxy]carbonyl]-2-phenylethyl ester
  • Xyotax
  • Paclitaxel poliglumex
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