CAS 263366-81-0

11,11'-piperazine-1,4-diylbis(8-chloro-5H-dibenzo[b,e][1,4]diazepine)

Description:

11,11'-Piperazine-1,4-diylbis(8-chloro-5H-dibenzo[b,e][1,4]diazepine) is a synthetic compound characterized by its complex structure, which includes a piperazine moiety and a dibenzo[b,e][1,4]diazepine framework. This compound features chlorine substituents that contribute to its chemical properties and potential biological activity. The presence of the piperazine group suggests possible interactions with biological targets, making it of interest in medicinal chemistry, particularly in the development of pharmaceuticals. The dibenzo[b,e][1,4]diazepine core is known for its diverse pharmacological effects, including anxiolytic and antipsychotic properties. The compound's molecular structure indicates it may exhibit lipophilicity, influencing its solubility and permeability in biological systems. Additionally, the specific arrangement of functional groups can affect its reactivity and stability. Overall, this compound represents a unique class of chemical entities that may have applications in drug discovery and development, although further studies would be necessary to elucidate its full pharmacological profile and potential therapeutic uses.

Formula: C₃₀H₂₄Cl₂N₆

InChI: InChI=1/C30H24Cl2N6/c31-19-9-11-25-27(17-19)35-29(21-5-1-3-7-23(21)33-25)37-13-15-38(16-14-37)30-22-6-2-4-8-24(22)34-26-12-10-20(32)18-28(26)36-30/h1-12,17-18,33-34H,13-16H2

SMILES: c1ccc2c(c1)C(=Nc1cc(ccc1N2)Cl)N1CCN(CC1)C1=Nc2cc(ccc2Nc2ccccc12)Cl

Synonyms:

• 5H-dibenzo[b,e][1,4]diazepine, 11,11'-(1,4-piperazinediyl)bis[8-chloro-
• 11,11'-Piperazine-1,4-diylbis(8-chloro-5H-dibenzo[b,e][1,4]diazepine)

11,11'-(Piperazine-1,4-diyl)bis(8-chloro-5H-dibenzo[b,e][1,4]-diazepine)

CAS: 263366-81-0

Formula: C₃₀H₂₄Cl₂N₆

Color and Shape: Neat

Molecular weight: 539.46

Ref: 86-MM0480.02

Clozapine EP Impurity B

CAS: 263366-81-0

Formula: C₃₀H₂₄Cl₂N₆

Color and Shape: Yellow Solid

Molecular weight: 539.46

Ref: 4Z-C-147

N-Desmethyl 8-Chloro-5H-dibenzo[b,e][1,4]diazepine Clozapine

Controlled Product

CAS: 263366-81-0

Impurity CLOZAPINE EP IMPURITY B
Applications N-Desmethyl 8-Chloro-5H-dibenzo[b,e][1,4]diazepine Clozapine is a Clozapine (C587500) impurity, an antipsychotic.
References Stille, et al: Farnaco, Ed. Prat., 26, 603 (1971), Hane, J.M., et al.: Psychopharmacol. Bull., 24, 62 (1988), Meltzer, H.Y.: J. Clin. Psychiatry, 55, Suppl. B, 47 (1994)

Formula: C₃₀H₂₄Cl₂N₆

Color and Shape: Neat

Molecular weight: 539.46

Ref: TR-D291975

Clozapine EP Impurity B

CAS: 263366-81-0

Formula: C₃₀H₂₄Cl₂N₆

Molecular weight: 539.46

Ref: ST-EA-CP-C63002

N-Desmethyl 8-Chloro-5H-dibenzo[b,e][1,4]diazepine Clozapine-d8

Controlled Product

CAS: 263366-81-0

Formula: C₃₀D₈H₁₆Cl₂N₆

Color and Shape: Neat

Molecular weight: 547.507

Ref: TR-D291977

11,11'-(Piperazine-1,4-diyl)-bis-8-chloro-5H-dibenze[b,e][1,4]diazepine

CAS: 263366-81-0

Clozapine is a drug that has been approved for the treatment of schizophrenia and other psychoses. It belongs to the class of atypical antipsychotics, which are more effective than typical antipsychotics in treating negative symptoms and may be better tolerated. Clozapine is a highly potent drug with many side effects. For example, it can cause sedation, dry mouth, constipation, weight gain, and agranulocytosis (low white blood cell count). Clozapine also has an effect on serum prolactin levels. Studies have shown that clozapine has a high affinity for 5-HT2 receptors, which are located throughout the brain. The clinical properties of clozapine include its ability to reduce body mass index and improve congestive heart failure in patients with Parkinson's disease. Clozapine is chemically stable in biological samples over time.

Formula: C₃₀H₂₄Cl₂N₆

Purity: Min. 95%

Molecular weight: 539.46 g/mol

Ref: 3D-FP159558