CAS 26339-90-2

Escin Ib

Description:

Escin Ib, with the CAS number 26339-90-2, is a triterpenoid saponin derived from the seeds of the horse chestnut tree (Aesculus hippocastanum). It is known for its potential therapeutic properties, particularly in the treatment of venous insufficiency and related conditions. Escin Ib exhibits anti-inflammatory and antioxidant activities, which contribute to its efficacy in promoting vascular health. The compound is characterized by its ability to enhance capillary permeability and reduce edema, making it beneficial in managing swelling and discomfort associated with various circulatory disorders. Additionally, escin compounds, including Escin Ib, are often studied for their role in improving microcirculation and providing protective effects against oxidative stress. While it is primarily recognized for its medicinal applications, further research continues to explore its full range of biological activities and potential uses in pharmacology. As with many natural compounds, the specific effects and mechanisms of action may vary, necessitating careful consideration in clinical applications.

Formula: C₅₅H₈₆O₂₄

InChI: InChI=1/C55H86O24/c1-10-23(2)46(71)79-43-44(72-24(3)60)55(22-59)26(17-50(43,4)5)25-11-12-30-51(6)15-14-32(52(7,21-58)29(51)13-16-53(30,8)54(25,9)18-31(55)61)75-49-41(77-48-38(67)36(65)34(63)28(20-57)74-48)39(68)40(42(78-49)45(69)70)76-47-37(66)35(64)33(62)27(19-56)73-47/h10-11,26-44,47-49,56-59,61-68H,12-22H2,1-9H3,(H,69,70)/b23-10-/t26-,27+,28+,29+,30+,31+,32-,33+,34+,35-,36-,37+,38+,39-,40-,41+,42-,43-,44-,47-,48-,49+,51-,52+,53+,54+,55-/m0/s1

InChI key: InChIKey=AXNVHPCVMSNXNP-OXPBSUTMSA-N

SMILES: C(O)[C@]12[C@](C=3[C@@](C)(C[C@H]1O)[C@@]4(C)[C@](CC3)([C@]5(C)[C@@](CC4)([C@](CO)(C)[C@@H](O[C@H]6[C@H](O[C@@H]7O[C@H](CO)[C@@H](O)[C@H](O)[C@H]7O)[C@@H](O)[C@H](O[C@@H]8O[C@H](CO)[C@@H](O)[C@H](O)[C@H]8O)[C@@H](C(O)=O)O6)CC5)[H])[H])(CC(C)(C)[C@@H](OC(/C(=C\C)/C)=O)[C@@H]2OC(C)=O)[H]

Synonyms:

• (3β,16α,21β,22α)-22-(acetyloxy)-16,24,28-trihydroxy-21-{[(2Z)-2-methylbut-2-enoyl]oxy}olean-12-en-3-yl β-D-glucopyranosyl-(1->2)-[β-D-glucopyranosyl-(1->4)]-β-D-glucopyranosiduronic acid
• (3β,4β,16α,21β,22α)-22-(Acetyloxy)-16,23,28-trihydroxy-21-[[(2Z)-2-methyl-1-oxo-2-buten-1-yl]oxy]olean-12-en-3-yl O-β-<span class="text-smallcaps">D</smallcap>-glucopyranosyl-(1→2)-O-[β-<smallcap>D</smallcap>-glucopyranosyl-(1→4)]-β-<smallcap>D</span>-glucopyranosiduronic acid
• Aescin B
• Olean-12-ene-16α,21β,22α,24,28-pentol, 3β-[(O-β-<span class="text-smallcaps">D</smallcap>-glucopyranosyl-(1→2)-O-[β-<smallcap>D</smallcap>-glucopyranosyl-(1→4)]-β-<smallcap>D</span>-glucopyranuronosyl)oxy]-, 22-acetate 21-((Z)-2-methylcrotonate)
• Oleanane, β-<span class="text-smallcaps">D</span>-glucopyranosiduronic acid deriv.
• beta-D-Glucopyranosiduronic acid, (3beta,16alpha,21beta(Z),22alpha)-22-(acetyloxy)-16,24,28-trihydroxy-21-((2-methyl-1-oxo-2-butenyl)oxy)olean-12-en-3-yl O-beta-D-glucopyranosyl-(1.2)-O-(beta-D-glucopyranosyl-(1.4))-
• escin Ib
• β-<span class="text-smallcaps">D</smallcap>-Glucopyranosiduronic acid, (3β,4β,16α,21β,22α)-22-(acetyloxy)-16,23,28-trihydroxy-21-[[(2Z)-2-methyl-1-oxo-2-buten-1-yl]oxy]olean-12-en-3-yl O-β-<smallcap>D</smallcap>-glucopyranosyl-(1→2)-O-[β-<smallcap>D</span>-glucopyranosyl-(1→4)]-
• β-<span class="text-smallcaps">D</smallcap>-Glucopyranosiduronic acid, (3β,4β,16α,21β,22α)-22-(acetyloxy)-16,23,28-trihydroxy-21-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]olean-12-en-3-yl O-β-<smallcap>D</smallcap>-glucopyranosyl-(1→2)-O-[β-<smallcap>D</span>-glucopyranosyl-(1→4)]-
• β-<span class="text-smallcaps">D</smallcap>-Glucopyranosiduronic acid, [3β,4β,16α,21β(Z),22α]-22-(acetyloxy)-16,23,28-trihydroxy-21-[(2-methyl-1-oxo-2-butenyl)oxy]olean-12-en-3-yl O-β-<smallcap>D</smallcap>-glucopyranosyl-(1→2)-O-[β-<smallcap>D</span>-glucopyranosyl-(1→4)]-
• Oleanane, β-D-glucopyranosiduronic acid deriv.
• β-D-Glucopyranosiduronic acid, [3β,4β,16α,21β(Z),22α]-22-(acetyloxy)-16,23,28-trihydroxy-21-[(2-methyl-1-oxo-2-butenyl)oxy]olean-12-en-3-yl O-β-D-glucopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→4)]-
• β-D-Glucopyranosiduronic acid, (3β,4β,16α,21β,22α)-22-(acetyloxy)-16,23,28-trihydroxy-21-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]olean-12-en-3-yl O-β-D-glucopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→4)]-
• Olean-12-ene-16α,21β,22α,24,28-pentol, 3β-[(O-β-D-glucopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→4)]-β-D-glucopyranuronosyl)oxy]-, 22-acetate 21-((Z)-2-methylcrotonate)
• β-D-Glucopyranosiduronic acid, (3β,4β,16α,21β,22α)-22-(acetyloxy)-16,23,28-trihydroxy-21-[[(2Z)-2-methyl-1-oxo-2-buten-1-yl]oxy]olean-12-en-3-yl O-β-D-glucopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→4)]-
• Aescin IB
• Escin IB(Aescin IB)
• Escin Impurity 2（Escin Ib）
• 22α-(Acetyloxy)-16α,24,28-trihydroxy-21β-[[(Z)-2-methyl-1-oxo-2-butenyl]oxy]oleana-12-ene-3β-yl 4-O-[2-O-(β-D-gluco-hexopyranosyl)-β-D-gluco-hexopyranosyl]-β-D-gluco-hexopyranosiduronic acid
• 3-<2''-(β-D-glucopyranosido)-4'-(β-D-glucopyranosido)-β-D-glucuronopyranosido>-21-β-angeloyl-22-α-acetylprotoescigenin
• β-d-Glucopyranosiduronic acid, [3β,16α,21β(Z),22α]-22-(acetyloxy)-16,24,28-trihydroxy-21-[(2-methyl-1-oxo-2-butenyl)oxy]olean-12-en-3-yl O-β-d-glucopyranosyl-(1→2)-O-[β-d-glucopyranosyl-(1→4)]-
• Aescin ib, 98%, from Aesculus wilsonii Rehder

Escin IB

CAS: 26339-90-2

Formula: C₅₅H₈₆O₂₄

Molecular weight: 1131.27

Ref: 7W-GY9075

Escin IB

CAS: 26339-90-2

Escin Ib inhibits gastric emptying, at least in part, mediated by capsaicin-sensitive sensory nerves, to stimulate the synthesis and/or release of dopamine, to act through central dopamine2 receptor, which in turn causes the release of PGs.

Formula: C₅₅H₈₆O₂₄

Purity: 95%~99%

Molecular weight: 1131.27

Ref: BP-BP0557

Escin IB

CAS: 26339-90-2

Escin Ib inhibits gastric emptying, at least in part, mediated by capsaicin-sensitive sensory nerves, to stimulate the synthesis and/or release of dopamine, to

Formula: C₅₅H₈₆O₂₄

Purity: 99.09% - 99.81%

Color and Shape: Solid

Molecular weight: 1131.26

Ref: TM-T5S1389

Escin IB

CAS: 26339-90-2

Formula: C₅₅H₈₆O₂₄

Molecular weight: 1131.27

Ref: 4Z-I-083004

Escin ib

CAS: 26339-90-2

Natural glycoside

Formula: C₅₅H₈₆O₂₄

Purity: ≥ 85.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 1131.26

Ref: 5G-80446

Escin Ib

CAS: 26339-90-2

Escin Ib is a natural saponin glycoside, which is derived from the seeds of Aesculus hippocastanum, commonly known as horse chestnut. Its mode of action involves inhibiting the enzyme hyaluronidase, thereby reducing capillary permeability and effectively controlling edema and inflammation. Additionally, it acts by stabilizing lysosomal membranes, further contributing to its anti-inflammatory effects.

Purity: Min. 95%

Ref: 3D-FE145234

Escin Impurity B

CAS: 26339-90-2

Formula: C₅₅H₈₆O₂₄

Molecular weight: 1131.27

Ref: ST-EA-CP-E104002

AESCIN IB(SH)

CAS: 26339-90-2

Formula: C₅₅H₈₆O₂₄

Purity: 103%

Color and Shape: Solid

Molecular weight: 1131.2569

Ref: IN-DA00BE5S