CAS 263843-55-6

H-Arg-Arg-AMC

Description:

H-Arg-Arg-AMC, also known as H-Arginine-Arginine-7-amido-4-methylcoumarin, is a synthetic peptide substrate commonly used in biochemical research, particularly in studies involving proteases and enzyme activity. This compound features a coumarin moiety, which serves as a fluorescent reporter, allowing for the detection of enzymatic cleavage. The presence of two arginine residues contributes to its specificity for certain enzymes, particularly those that recognize basic amino acids. H-Arg-Arg-AMC is typically utilized in assays to monitor proteolytic activity, as the cleavage of the peptide bond releases the fluorescent AMC group, resulting in an increase in fluorescence that can be quantitatively measured. This property makes it a valuable tool in drug discovery and the study of various biological processes. Additionally, the stability and solubility of H-Arg-Arg-AMC in aqueous solutions make it suitable for in vitro experiments. As with any chemical substance, proper handling and safety precautions should be observed during its use in laboratory settings.

Formula: C₂₂H₃₃N₉O₄

Synonyms:

• L-Argininamide, L-arginyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-

H-Arg-Arg-AMC

CAS: 263843-55-6

RR-AMC, fluorogenic substrate for dipeptidyl peptidase III (DPP III).

Formula: C₂₂H₃₃N₉O₄

Purity: > 98%

Color and Shape: White

Molecular weight: 487.56

Ref: 01-4004120

H-Arg-Arg-AMC hydrochloride salt

CAS: 263843-55-6

H-Arg-Arg-AMC hydrochloride salt is a proteolytic inhibitor that binds to the active site of aminopeptidases and prevents their proteolytic activity. This inhibition leads to increased muscle mass in juveniles, as well as higher concentrations of magnesium ions in sarcoplasmic and myofibrillar proteins. H-Arg-Arg-AMC hydrochloride salt also has an inhibitory effect on ion exchange and chloride transport in muscle cells. The biochemical effects of this drug are due to its ability to inhibit the aminopeptidase enzymes, which play a role in the metabolism of amino acids.

Formula: C₂₂H₃₃N₉O₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 487.56 g/mol

Ref: 3D-FA110477