C14-490, identified by its CAS number 2639634-82-3, is a chemical compound that belongs to a specific class of substances often utilized in research and industrial applications. While detailed characteristics such as molecular structure, physical properties, and specific applications may vary, compounds like C14-490 typically exhibit unique reactivity profiles and may serve as intermediates in organic synthesis or as functional materials in various fields. The compound's solubility, stability, and interaction with other chemicals are crucial for its application, and it may possess specific functional groups that dictate its behavior in chemical reactions. Safety data sheets and regulatory information are essential for handling this substance, as they provide insights into its toxicity, environmental impact, and necessary precautions. For precise applications and characteristics, consulting specialized literature or databases is recommended, as they provide comprehensive details tailored to specific research or industrial needs.

C14-490 is an ionizable cationic lipid (pKa = 5.94).1 It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo.{55518,​77043} C14-490-containing LNPs accumulate primarily in the fetal mouse liver and, to a lesser extent, in the lungs, intestine, and brain after vitelline vein injection on gestational day 16 (E16).1 CD45-functionalized LNPs containing C14-490 and encapsulating mRNA encoding GFP transfect Jurkat cells, which constitutively express the CD45 receptor (CD45R).{​77043} C14-490-containing CD45-functionalized LNPs encapsulating Cre mRNA mediate genome modulation in bone marrow hematopoietic stem cells (HSCs) for at least four months after in utero injection in R26mT/mG mice at E13.5. WARNING This product is not for human or veterinary use.

C14-490

2639634-82-3: C14-490, identified by its CAS number 2639634-82-3, is a chemical compound that belongs to a specific class of substances often utilized in research and industrial applications. While detailed characteristics such as molecular structure, physical properties, and specific applications may vary, compounds like C14-490 typically exhibit unique reactivity profiles and may serve as intermediates in organic synthesis or as functional materials in various fields. The compound's solubility, stability, and interaction with other chemicals are crucial for its application, and it may possess specific functional groups that dictate its behavior in chemical reactions. Safety data sheets and regulatory information are essential for handling this substance, as they provide insights into its toxicity, environmental impact, and necessary precautions. For precise applications and characteristics, consulting specialized literature or databases is recommended, as they provide comprehensive details tailored to specific research or industrial needs.

<p>C14-490 is an ionizable cationic lipid (pKa= 5.94) utilized in the synthesis of lipid nanoparticles (LNPs). These LNPs serve as a platform for subsequent gene editing studies in hematopoietic stem cells (HSCs) in utero. C14-490 LNPs encapsulate SpCas9 mRNA and TTR sgRNA, employing an optimized B5 formulation parameter, and are further enhanced by the surface attachment of CD45 antibody F(ab’)2 fragments to create Systemically Targeted Editing Mechanism LNPs (STEM LNPs).</p>

CAS 2639634-82-3

C14-490

C14-490

Ref: TM-TYD-01884