CAS 264218-23-7

SB 415286

Description:

SB 415286, with the CAS number 264218-23-7, is a chemical compound that has garnered attention in the field of medicinal chemistry, particularly for its potential therapeutic applications. It is characterized as a selective inhibitor of certain protein kinases, which play crucial roles in various cellular processes, including cell growth, division, and apoptosis. The compound's structure typically features a core that allows for specific interactions with its target kinases, enhancing its selectivity and efficacy. In preclinical studies, SB 415286 has shown promise in modulating signaling pathways associated with cancer and other diseases, making it a candidate for further investigation in drug development. Its pharmacokinetic properties, such as absorption, distribution, metabolism, and excretion (ADME), are essential for determining its suitability for clinical use. As with many investigational compounds, ongoing research aims to elucidate its full therapeutic potential and safety profile.

Formula: C₁₆H₁₀ClN₃O₅

InChI: InChI=1/C16H10ClN3O5/c17-10-7-8(5-6-12(10)21)18-14-13(15(22)19-16(14)23)9-3-1-2-4-11(9)20(24)25/h1-7,21H,(H2,18,19,22,23)

InChI key: InChIKey=PQCXVIPXISBFPN-UHFFFAOYSA-N

SMILES: N(C1=C(C(=O)NC1=O)C2=C(N(=O)=O)C=CC=C2)C3=CC(Cl)=C(O)C=C3

Synonyms:

• 1H-Pyrrole-2,5-dione, 3-[(3-chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-
• Sb 415286
• 3-[(3-Chloro-4-hydroxyphenyl)-amino]-4-(2-nitrophenyl)-1H-pyrrol-2,5-dione
• 3-[(3-Chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione
• 3-[(3-Chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione
• SB-41528
• SB 415286 USP/EP/BP
• CS-228
• SB-415286; SB415286

1H-Pyrrole-2,5-dione, 3-[(3-chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-

CAS: 264218-23-7

Formula: C₁₆H₁₀ClN₃O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 359.7207

Ref: IN-DA002T5A

SB 415286

CAS: 264218-23-7

SB 415286

Purity: ≥98%

Molecular weight: 359.72g/mol

Ref: 54-BUP06463

SB 415286

CAS: 264218-23-7

Formula: C₁₆H₁₀N₃O₅Cl

Molecular weight: 359.72

Ref: 7W-GL2098

SB 415286

CAS: 264218-23-7

SB 415286 is a potent GSK3α inhibitor with IC50/Ki of 78 nM/31 nM with equally effective inhibition of GSK-3β.

Formula: C₁₆H₁₀ClN₃O₅

Purity: 99.55%

Color and Shape: Solid

Molecular weight: 359.72

Ref: TM-T6659

1H-Pyrrole-2,5-dione, 3-[(3-chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-

CAS: 264218-23-7

Purity: 98%

Molecular weight: 359.7200012

Ref: 10-F862293

SB-415286

CAS: 264218-23-7

SB-415286 is a small molecule inhibitor of GSK-3β. It prevents phosphorylation of the substrate by GSK-3β, thereby preventing the inhibition of downstream signaling pathways, such as those that regulate energy metabolism and neuronal death. SB-415286 has been shown to inhibit 3t3-l1 preadipocytes differentiation into adipocytes, although it does not inhibit proliferation or stimulate apoptosis. This agent also inhibits neuronal death in axons and axon regeneration in t-cell lymphomas, suggesting that this drug may be useful for treating diseases like Alzheimer's disease or stroke.

Formula: C₁₆H₁₀ClN₃O₅

Purity: Min. 95%

Molecular weight: 359.72 g/mol

Ref: 3D-PKA21823