CAS 26441-05-4

15-keto-PGE2

Description:

15-keto-PGE2, or 15-keto-prostaglandin E2, is a metabolite of prostaglandin E2 (PGE2), which is a bioactive lipid involved in various physiological processes, including inflammation, pain modulation, and regulation of blood flow. This compound is characterized by the presence of a keto group at the 15th carbon position of the prostaglandin structure, which distinguishes it from its parent compound, PGE2. The molecular structure of 15-keto-PGE2 includes a cyclopentane ring and multiple functional groups, contributing to its biological activity. It is known to exhibit anti-inflammatory properties and may play a role in various pathophysiological conditions. The compound is typically studied in the context of its effects on cellular signaling pathways and its potential therapeutic applications. As a chemical entity, 15-keto-PGE2 is soluble in organic solvents and has specific interactions with receptors and enzymes involved in prostaglandin metabolism. Its CAS number, 26441-05-4, is used for identification in chemical databases and regulatory contexts.

Formula: C₂₀H₃₀O₅

InChI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,16-17,19,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t16-,17-,19-/m1/s1

InChI key: InChIKey=YRTJDWROBKPZNV-KMXMBPPJSA-N

SMILES: C(/C=C\CCCC(O)=O)[C@@H]1[C@@H](/C=C/C(CCCCC)=O)[C@H](O)CC1=O

Synonyms:

• (5Z,11alpha,13E)-11-hydroxy-9,15-dioxoprosta-5,13-dien-1-oic acid
• (5Z,11α,13E)-11-Hydroxy-9,15-dioxoprosta-5,13-dien-1-oic acid
• 15-Dehydroprostaglandin E₂
• 15-Keto PGE₂
• 15-Keto-PGE2
• 15-Keto-prostaglandin E2
• 15-Ketoprostaglandin E₂
• 15-Oxo-PGE2
• 15-Oxo-PGE₂
• 15-Oxoprostaglandin E₂
• 15-keto-Prostaglandin E₂
• 5-Heptenoic acid, 7-[3-hydroxy-5-oxo-2-(3-oxo-1-octenyl)cyclopentyl]-, stereoisomer
• 9,15-Dioxo-11-hydroxyprosta-5,13-dienoic acid
• Prosta-5,13-dien-1-oic acid, 11-hydroxy-9,15-dioxo-, (5Z,11alpha,13E)-
• Prosta-5,13-dien-1-oic acid, 11-hydroxy-9,15-dioxo-, (5Z,11α,13E)-
• 15-Dehydroprostaglandin E2

15-keto-PGE2

CAS: 26441-05-4

Formula: C₂₀H₃₀O₅

Molecular weight: 350.4492

Ref: IN-DA002T89

(Z)-7-((1R,2R,3R)-3-Hydroxy-5-oxo-2-((E)-3-oxooct-1-en-1-yl)cyclopentyl)hept-5-enoic acid

CAS: 26441-05-4

(Z)-7-((1R,2R,3R)-3-Hydroxy-5-oxo-2-((E)-3-oxooct-1-en-1-yl)cyclopentyl)hept-5-enoic acid

Purity: 98%

Molecular weight: 350.46g/mol

Ref: 54-OR1073762

Alprostadil (Prostaglandin E1) Impurity 6

CAS: 26441-05-4

Formula: C₂₀H₃₀O₅

Molecular weight: 350.46

Ref: 4Z-P-144036

15-Keto Prostaglandin E2

Controlled Product

CAS: 26441-05-4

Applications 15-Keto Prostaglandin E2 is a lipid compound derived from arachidonic acid by the action of cyclooxygenases. Prostaglandins act locally as messenger molecules in a variety of physiological processes.
References Mesa, J., et al.: Chem Biol Interact, 234, 105-113 (2015)

Formula: C₂₀H₃₀O₅

Color and Shape: Neat

Molecular weight: 350.449

Ref: TR-K202060

Dinoprostone EP Impurity F

CAS: 26441-05-4

Formula: C₂₀H₃₀O₅

Molecular weight: 350.45

Ref: ST-EA-CP-D117007

15-keto-Prostaglandin E2

CAS: 26441-05-4

15-keto-Prostaglandin E2, an endogenous metabolite, inhibits STAT3 activation through binding to Cys259 and regulates breast cancer cell growth and progression.

Formula: C₂₀H₃₀O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 350.45

Ref: TM-T78582