CAS 2646-38-0

Sodium chenodeoxycholate

Description:

Sodium chenodeoxycholate, with the CAS number 2646-38-0, is a bile salt derived from chenodeoxycholic acid, which is a naturally occurring bile acid in the human body. It is a white to off-white powder that is soluble in water and exhibits amphipathic properties, allowing it to interact with both hydrophilic and hydrophobic substances. This compound plays a significant role in the emulsification and absorption of dietary fats and fat-soluble vitamins in the intestine. Sodium chenodeoxycholate is often used in pharmaceutical formulations, particularly in the treatment of certain types of gallstones and as a cholesterol-lowering agent. Additionally, it has applications in biochemistry and molecular biology as a detergent for membrane protein solubilization and purification. Its safety profile indicates that it should be handled with care, as it can cause irritation upon contact with skin or mucous membranes. Overall, sodium chenodeoxycholate is an important compound in both physiological processes and various industrial applications.

Formula: C₂₄H₄₀O₄·Na

InChI: InChI=1S/C24H40O4.Na/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26;/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28);/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-;/m1./s1

InChI key: InChIKey=DOVZGADDWOFQEZ-OICFXQLMSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@](C[C@H]3O)(C[C@H](O)CC4)[H])(CC1)[H])[H])(CC[C@@]2([C@@H](CCC(O)=O)C)[H])[H].[Na]

Synonyms:

• 5-beta-Cholan-24-oic acid, 3-alpha,7-alpha-dihydroxy-, monosodium salt
• 5β-Cholan-24-oic acid, 3α,7α-dihydroxy-, monosodium salt
• 5β-Cholanic acid, 3α,7α-dihydroxy-, sodium salt
• Ccris 637
• Chenodeoxycholic acid sodium salt
• Cholan-24-Oic Acid, 3,7-Dihydroxy-, Monosodium Salt, (3Alpha,5Beta,7Beta)-
• Cholan-24-oic acid, 3,7-dihydroxy-, monosodium salt, (3-alpha,5-beta,7-alpha)- (9CI)
• Cholan-24-oic acid, 3,7-dihydroxy-, monosodium salt, (3α,5β,7α)-
• NSC 681066
• Sodium chenodeoxycholate
• Sodium chenodesoxycholate
• Unii-6V4571Kske
• sodium (3beta,7beta,8xi,9beta,10xi,13xi,14beta,17alpha,20S)-3,7-dihydroxycholan-24-oate

Sodium Chenodeoxycholate

CAS: 2646-38-0

Formula: C₂₄H₃₉NaO₄

Purity: >97.0%(GC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 414.56

Ref: 3B-S0941

Chenodeoxycholic Acid (sodium salt)

CAS: 2646-38-0

Formula: C₂₄H₃₉NaO₄

Purity: 97%

Color and Shape: Solid

Molecular weight: 414.5538

Ref: IN-DA002TB3

Chenodeoxycholic acid sodium salt

CAS: 2646-38-0

Formula: C₂₄H₃₉NaO₄

Purity: ≥ 97.0% (anhydrous basis)

Color and Shape: White or almost white powder

Molecular weight: 414.55

Ref: 7W-GL7692

Chenodeoxycholic Acid sodium salt

CAS: 2646-38-0

Chenodeoxycholic Acid sodium salt

Purity: ≥98%

Molecular weight: 414.55g/mol

Ref: 54-BUP16473

Sodium Chenodeoxycholate

CAS: 2646-38-0

Sodium Chenodeoxycholate

Purity: 97%

Molecular weight: 414.55g/mol

Ref: 54-OR1028864

Chenodeoxycholic Acid sodium salt

CAS: 2646-38-0

Chenodeoxycholic Acid sodium salt (CDCA sodium salt) is a bile acid in humans that activates the nuclear receptor FXR, rescues axonal degeneration of induced pluripotent stem cell-derived neurons in patients with spastic paraplegia type 5 and cerebral xanthomatosis, and can be used to study pancreatic necrosis.

Formula: C₂₄H₃₉NaO₄

Purity: 99.68% - 99.72%

Color and Shape: Solid

Molecular weight: 414.55

Ref: TM-T65070

Chenodeoxycholic acid, sodium salt

Controlled Product

CAS: 2646-38-0

Chenodeoxycholic acid, sodium salt is a bile acid that is derived from ursodeoxycholic acid. It has been used in the treatment of gallstones and primary biliary cirrhosis. Chenodeoxycholic acid, sodium salt inhibits the production of cholesterol by blocking the action of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) enzyme, which is responsible for catalyzing the conversion of HMG-CoA to mevalonate. Chenodeoxycholic acid also inhibits the growth of tumor cells and has antiinflammatory properties due to its ability to inhibit prostaglandin synthesis. This drug may interact with drugs that are substrates for either chenodeoxycholic acid or cytochrome P450 enzymes.

Formula: C₂₄H₃₉NaO₄

Color and Shape: White Off-White Powder

Molecular weight: 414.57 g/mol

Ref: 3D-FC16279

Sodium Chenodeoxycholate

CAS: 2646-38-0

Purity: 98%

Molecular weight: 414.27

Ref: 10-F556643

Chenodeoxycholic Acid Sodium Salt

Controlled Product

CAS: 2646-38-0

Applications Chenodeoxycholic Acid, Sodium Salt is a bile acid used in rat hepatocyte studies. It can be used in biological study of interaction between dietary bioactive peptides of short length and bile salts in submicellar or micellar state.
References Guerin, J., et al.: Food Chem, 209, 114 (2016)

Formula: C₂₄H₃₉O₄·Na

Color and Shape: Neat

Molecular weight: 414.554

Ref: TR-C291935