CAS 265114-23-6

Cimicoxib

Description:

Cimicoxib is a non-steroidal anti-inflammatory drug (NSAID) that belongs to the class of selective cyclooxygenase-2 (COX-2) inhibitors. It is primarily used for its analgesic and anti-inflammatory properties, making it effective in treating conditions such as osteoarthritis and other inflammatory disorders. The chemical structure of Cimicoxib features a sulfonamide group, which contributes to its pharmacological activity. It exhibits a high affinity for COX-2, leading to reduced production of prostaglandins involved in inflammation and pain. The substance is characterized by its relatively low toxicity profile compared to traditional NSAIDs, which often inhibit both COX-1 and COX-2 enzymes, potentially leading to gastrointestinal side effects. Cimicoxib is typically administered in oral form and is subject to specific regulatory approvals in various countries for veterinary or human use. Its efficacy and safety profile make it a valuable option in pain management, although, like all medications, it should be used under medical supervision to monitor for potential adverse effects.

Formula: C₁₆H₁₃ClFN₃O₃S

InChI: InChI=1S/C16H13ClFN3O3S/c1-24-14-7-2-10(8-13(14)18)15-16(17)20-9-21(15)11-3-5-12(6-4-11)25(19,22)23/h2-9H,1H3,(H2,19,22,23)

InChI key: InChIKey=KYXDNECMRLFQMZ-UHFFFAOYSA-N

SMILES: ClC1=C(N(C=N1)C2=CC=C(S(N)(=O)=O)C=C2)C3=CC(F)=C(OC)C=C3

Synonyms:

• 4-[4-Chloro-5-(3-fluoro-4-methoxyphenyl)imidazol-1-yl]benzenesulfonamide
• Benzenesulfonamide, 4-[4-chloro-5-(3-fluoro-4-methoxyphenyl)-1H-imidazol-1-yl]-
• Cimalgex
• Cimicoxib
• Ur-8880
• 4-[4-Chloro-5-(3-fluoro-4-methoxyphenyl)-1H-imidazol-1-yl]benzenesulfonamide

4-(4-Chloro-5-(3-fluoro-4-methoxyphenyl)-1H-imidazol-1-yl)benzenesulfonamide

CAS: 265114-23-6

Formula: C₁₆H₁₃ClFN₃O₃S

Purity: 98%

Color and Shape: Solid

Molecular weight: 381.8091

Ref: IN-DA002TJ0

Cimicoxib

CAS: 265114-23-6

Cimicoxib

Purity: ≥98%

Molecular weight: 381.81g/mol

Ref: 54-BUP03591

Cimicoxib

Controlled Product

CAS: 265114-23-6

Applications Cimicoxib is a long-acting COX-2 Inhibitor and is developed as a non-steroidal anti-inflammatory veterinary drug used to treat dogs with inflammation and pain associated with osteoarthritis.
References Zambre, A.P., et al.: J. Chem. Info. Model., 47, 635 (2007); Sorbera, I.A., et al.: Drugs. Future., 29, 325 (2004); Almansa, C., et al.: J. Med. Chem., 3463 (2003);

Formula: C₁₆H₁₃ClFN₃O₃S

Color and Shape: Neat

Molecular weight: 381.81

Ref: TR-C441690

Cimicoxib

CAS: 265114-23-6

Cimicoxib (UR8880) is a potent and selective inhibitor of COX-2 with anti-inflammatory and analgesic activity.

Formula: C₁₆H₁₃ClFN₃O₃S

Purity: 98.22%

Color and Shape: Solid

Molecular weight: 381.81

Ref: TM-T30937