CAS 265114-54-3

Telomestatin

Description:

Telomestatin is a naturally occurring compound known for its unique structure and biological activity. It is classified as a telomerase inhibitor, which means it can interfere with the enzyme telomerase that is often overexpressed in cancer cells, thereby potentially inhibiting their proliferation. The compound is derived from the fermentation of certain actinomycetes and has garnered interest in cancer research due to its ability to induce apoptosis in cancer cells. Telomestatin exhibits a complex molecular structure, characterized by a bicyclic core and multiple functional groups that contribute to its biological activity. Its mechanism of action involves binding to the G-quadruplex structures formed at the ends of telomeres, stabilizing them and preventing telomerase from elongating the telomeres. This action can lead to telomere shortening and eventual cell death in rapidly dividing cells. Additionally, telomestatin has shown potential in various preclinical studies, highlighting its promise as a therapeutic agent in oncology. However, further research is needed to fully understand its efficacy and safety in clinical applications.

Formula: C₂₆H₁₄N₈O₇S

InChI: InChI=1S/C26H14N8O7S/c1-9-17-24-30-14(6-39-24)21-28-12(4-37-21)19-27-11(3-35-19)20-29-13(5-36-20)22-31-15(7-38-22)26-32-16(8-42-26)23-33-18(10(2)40-23)25(34-17)41-9/h3-7,16H,8H2,1-2H3/t16-/m0/s1

InChI key: InChIKey=YVSQVYZBDXIXCC-INIZCTEOSA-N

SMILES: CC1=C2C3=NC(=C(C)O3)C4=NC(=CO4)C5=NC(=CO5)C6=NC(C7=NC(C8=NC(C9=N[C@](C(=N2)O1)(CS9)[H])=CO8)=CO7)=CO6

Synonyms:

• GM 95
• Telomestatin
• (1R)-4,8-Dimethyl-3,7,11,15,19,23,27-heptaoxa-31-thia-33,34,35,36,37,38,39,40-octaazanonacyclo[28.2.1.12,5.16,9.110,13.114,17.118,21.122,25.126,29]tetraconta-2(40),4,6(39),8,10(38),12,14(37),16,18(36),20,22(35),24,26(34),28,30(33)-pentadecaene
• 3,7,11,15,19,23,27-Heptaoxa-31-thia-33,34,35,36,37,38,39,40-octaazanonacyclo[28.2.1.12,5.16,9.110,13.114,17.118,21.122,25.126,29]tetraconta-2(40),4,6(39),8,10(38),12,14(37),16,18(36),20,22(35),24,26(34),28,30(33)-pentadecaene, 4,8-dimethyl-, (1R)-
• SOT 095

Telomestatin

CAS: 265114-54-3

Telomestatin inhibits telomerase, converting hybrid G-quadruplexes to basket-type in telomeres.

Formula: C₂₆H₁₄N₈O₇S

Color and Shape: Solid

Molecular weight: 582.5

Ref: TM-T28942

Telomestatin

CAS: 265114-54-3

Telomestatin is a peptide that is an activator of ion channels. It is also an inhibitor of protein interactions and receptor-ligand binding. Telomestatin is an inhibitor of the potassium channel, which regulates the passage of potassium ions through cell membranes. This inhibition causes hyperpolarization in cells, which leads to a decreased rate of excitation and subsequent inhibition of nerve activity. Telomestatin has been shown to be effective in inhibiting the growth of human breast cancer cells by interfering with potassium channels in the membrane.

Formula: C₂₆H₁₄N₈O₇S

Purity: Min. 95%

Molecular weight: 582.5 g/mol

Ref: 3D-QKA11454