The chemical substance known as "2-[[2-Methyl-5-(trifluoromethyl)phenyl]amino]-N-[(tetrahydro-1,4-oxazepin-4(5H)-yl)sulfonyl]-4-oxazolecarboxamide" with CAS number 2660230-90-8 is characterized by its complex molecular structure, which includes multiple functional groups such as an oxazole ring, an amine, and a sulfonamide. This compound is likely to exhibit properties typical of sulfonamides, including potential antibacterial activity, and may also possess unique pharmacological properties due to the presence of the trifluoromethyl group, which can enhance lipophilicity and metabolic stability. The tetrahydro-1,4-oxazepin moiety may contribute to its biological activity by influencing receptor binding or enzyme interactions. Additionally, the presence of the carboxamide group suggests potential for hydrogen bonding, which can affect solubility and bioavailability. Overall, this compound's characteristics make it a candidate for further investigation in medicinal chemistry, particularly in the development of therapeutic agents.

2-[[2-Methyl-5-(trifluoromethyl)phenyl]amino]-N-[(tetrahydro-1,4-oxazepin-4(5H)-yl)sulfonyl]-4-oxazolecarboxamide

2660230-90-8: The chemical substance known as "2-[[2-Methyl-5-(trifluoromethyl)phenyl]amino]-N-[(tetrahydro-1,4-oxazepin-4(5H)-yl)sulfonyl]-4-oxazolecarboxamide" with CAS number 2660230-90-8 is characterized by its complex molecular structure, which includes multiple functional groups such as an oxazole ring, an amine, and a sulfonamide. This compound is likely to exhibit properties typical of sulfonamides, including potential antibacterial activity, and may also possess unique pharmacological properties due to the presence of the trifluoromethyl group, which can enhance lipophilicity and metabolic stability. The tetrahydro-1,4-oxazepin moiety may contribute to its biological activity by influencing receptor binding or enzyme interactions. Additionally, the presence of the carboxamide group suggests potential for hydrogen bonding, which can affect solubility and bioavailability. Overall, this compound's characteristics make it a candidate for further investigation in medicinal chemistry, particularly in the development of therapeutic agents.

<p>NLRP3-IN-25 (compound 32), an orally available NLRP3 inhibitor, exhibits anti-inflammatory properties by attenuating renal injury in a mouse model of doxorubicin-induced glomerulonephritis and inhibiting IL-1β secretion in THP-1 cells, with an IC 50 value of 21 nM [1].</p>

CAS 2660230-90-8

2-[[2-Methyl-5-(trifluoromethyl)phenyl]amino]-N-[(tetrahydro-1,4-oxazepin-4(5H)-yl)sulfonyl]-4-oxazolecarboxamide

NLRP3-IN-25

Ref: TM-T87016