CAS 26605-16-3

Desferrioxamine E

Description:

Desferrioxamine E is a chelating agent primarily used in the treatment of iron overload conditions, such as those resulting from repeated blood transfusions in patients with conditions like thalassemia. It is a member of the desferrioxamine family, which are hydroxamic acid derivatives that effectively bind free iron ions, facilitating their excretion from the body. This compound is characterized by its ability to form stable complexes with ferric ions, thus preventing iron from participating in harmful biochemical reactions that can lead to oxidative stress and tissue damage. Desferrioxamine E is typically administered parenterally, as its oral bioavailability is limited. In addition to its therapeutic applications, it has been studied for its potential use in various research contexts, including its role in cellular iron metabolism and its effects on microbial growth. The compound is generally recognized for its safety profile, although potential side effects may include allergic reactions and gastrointestinal disturbances. Overall, Desferrioxamine E plays a crucial role in managing iron overload and is an important tool in clinical settings.

Formula: C₂₇H₄₈N₆O₉

InChI: InChI=1S/C27H48N6O9/c34-22-10-14-26(38)32(41)20-8-3-6-18-30-24(36)12-15-27(39)33(42)21-9-2-5-17-29-23(35)11-13-25(37)31(40)19-7-1-4-16-28-22/h40-42H,1-21H2,(H,28,34)(H,29,35)(H,30,36)

InChI key: InChIKey=NHKCCADZVLTPPO-UHFFFAOYSA-N

SMILES: O=C1N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CC1

Synonyms:

• 1,6,12,17,23,28-Hexaazacyclotritriacontane-2,5,13,16,24,27-hexone, 1,12,23-trihydroxy-
• 26605-16-3
• Deferriferrioxamine E
• Deferrioxamine E
• Desferrioxamine E
• Nocardamin
• Nocardamine
• Proferrioxamine E
• 1,12,23-Trihydroxy-1,6,12,17,23,28-hexaazacyclotritriacontane-2,5,13,16,24,27-hexone

Nocardamine

CAS: 26605-16-3

Formula: C₂₇H₄₈N₆O₉

Molecular weight: 600.7048

Ref: IN-DA002TU8

Nocardamine

CAS: 26605-16-3

Nocardamine, a Streptomyces siderophore, chelates iron (IC50=9.9 μM), inhibits biofilms (MIC=10 μM), is cytotoxic to cancer cells, and affects insect cells.

Formula: C₂₇H₄₈N₆O₉

Color and Shape: Solid

Molecular weight: 600.7

Ref: TM-T36539

Nocardamine

CAS: 26605-16-3

Nocardamine

Purity: 98%

Molecular weight: 600.7g/mol

Ref: 54-OR1075425

Nocardamine

CAS: 26605-16-3

Formula: C₂₇H₄₈N₆O₉

Purity: ≥ 95.0%

Color and Shape: White to off-white solid

Molecular weight: 600.70

Ref: 7W-GA4846

Nocardamine

Controlled Product

CAS: 26605-16-3

Formula: C₂₇H₄₈N₆O₉

Color and Shape: Neat

Molecular weight: 600.705

Ref: TR-N634083

Desferrioxamine E

CAS: 26605-16-3

Formula: C₂₇H₄₈N₆O₉

Molecular weight: 600.7

Ref: ST-EA-CP-D177011

Nocardamine

CAS: 26605-16-3

Nocardamine is a siderophore-based antioxidant, which is naturally derived from the soil-dwelling actinobacteria known as Streptomyces. Its primary mode of action involves the chelation of metal ions, effectively sequestering them and preventing metal-catalyzed oxidation reactions. By binding to iron and other transition metals, Nocardamine mitigates oxidative stress at a cellular level, which could otherwise contribute to cellular damage and dysfunction.

Formula: C₂₇H₄₈N₆O₉

Purity: Min. 95%

Molecular weight: 600.71 g/mol

Ref: 3D-FN175540