CAS 26605-69-6

Carbenicillin indanyl sodium

Description:

Carbenicillin indanyl sodium is a semi-synthetic antibiotic belonging to the penicillin class, specifically designed to enhance the stability and bioavailability of carbenicillin. It is characterized by its broad-spectrum activity against various Gram-negative and some Gram-positive bacteria, making it useful in treating infections caused by susceptible organisms. The compound is typically administered via injection and is known for its ability to resist degradation by certain beta-lactamases, enzymes produced by bacteria that can inactivate many penicillins. Carbenicillin indanyl sodium is particularly effective against Pseudomonas aeruginosa and other enteric bacteria. Its pharmacokinetics involve rapid absorption and distribution in the body, with renal excretion being the primary route of elimination. As with other antibiotics, potential side effects may include allergic reactions, gastrointestinal disturbances, and alterations in normal flora. Due to the emergence of antibiotic resistance, the use of carbenicillin indanyl sodium should be guided by susceptibility testing and clinical judgment.

Formula: C₂₆H₂₆N₂O₆S·Na

InChI: InChI=1S/C26H26N2O6S.Na/c1-26(2)20(24(31)32)28-22(30)19(23(28)35-26)27-21(29)18(15-7-4-3-5-8-15)25(33)34-17-12-11-14-9-6-10-16(14)13-17;/h3-5,7-8,11-13,18-20,23H,6,9-10H2,1-2H3,(H,27,29)(H,31,32);/t18?,19-,20+,23-;/m1./s1

InChI key: InChIKey=MIDVDPGGKUZZAJ-XZVIDJSISA-N

SMILES: N(C(C(C(OC=1C=C2C(=CC1)CCC2)=O)C3=CC=CC=C3)=O)[C@H]4[C@@]5(N([C@@H](C(O)=O)C(C)(C)S5)C4=O)[H].[Na]

Synonyms:

• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[3-[(2,3-dihydro-1H-inden-5-yl)oxy]-1,3-dioxo-2-phenylpropyl]amino]-3,3-dimethyl-7-oxo-, monosodium salt, (2S,5R,6R)-
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[3-[(2,3-dihydro-1H-inden-5-yl)oxy]-1,3-dioxo-2-phenylpropyl]amino]-3,3-dimethyl-7-oxo-, monosodium salt, [2S-(2α,5α,6β)]-
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[3-[(2,3-dihydro-1H-inden-5-yl)oxy]-1,3-dioxo-2-phenylpropyl]amino]-3,3-dimethyl-7-oxo-, sodium salt (1:1), (2S,5R,6R)-
• 5-Indanol, 6-ester with 6-(2-carboxy-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid monosodium salt
• 5-Indanol, N-(2-carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-6-yl)-2-phenylmalonamate monosodium salt
• Carbenicillin Indanyl Sodium
• Carindapen
• Cp 15464-2
• GU-Pen
• Geocillin
• Indanyl carbenicillin sodium salt
• Malonamic acid, N-(2-carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-6-yl)-2-phenyl-, 1-(5-indanyl) ester, monosodium salt
• Monosodium indanyl carbenicillin
• Sodium 5-indanylcarbenicillin
• Sodium indanylcarbenicillin
• sodium (2S,5R,6R)-6-{[3-(2,3-dihydro-1H-inden-5-yloxy)-3-oxo-2-phenylpropanoyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

Carindacillin sodium

CAS: 26605-69-6

Carindacillin sodium, orally active broad-spectrum antibiotic, hydrolyzes to Carbenicillin, used in urinary tract infection studies.

Formula: C₂₆H₂₅N₂NaO₆S

Color and Shape: Solid

Molecular weight: 516.54

Ref: TM-T40295

Sodium Indanylcarbinicillin

Controlled Product

CAS: 26605-69-6

Stability Temperature sensitive
Applications Has been shown to reduce blood pressure in mammals and also has been used as a β-lactam antibiotic.
References Tsuji, A. et al.: J. Pharma. Sci., 66, 1675 (1977); Otsuki, I. et al.: Chemother., 23, 583 (1975);

Formula: C₂₆H₂₅N₂O₆S·Na

Purity: >90%

Color and Shape: Neat

Molecular weight: 516.54

Ref: TR-S635000

Carbenicillin Indanyl Sodium (DISCONTINUED)

CAS: 26605-69-6

Penicillins and their derivatives with a penicillanic acid structure and salts thereof, nesoi

Formula: C₂₆H₂₆N₂O₆S·Na

Color and Shape: Powder

Molecular weight: 517.14093

Ref: 45-1093500