CAS 26615-21-4

Zotepine

Description:

Zotepine is an atypical antipsychotic medication primarily used in the treatment of schizophrenia and other psychotic disorders. It belongs to the class of dibenzothiazepines and exhibits a complex pharmacological profile, acting as an antagonist at various neurotransmitter receptors, including dopamine D2 and serotonin 5-HT2A receptors. This dual action is thought to contribute to its efficacy in alleviating both positive and negative symptoms of schizophrenia. Zotepine is characterized by its relatively low incidence of extrapyramidal side effects compared to typical antipsychotics, making it a preferred option for some patients. The substance is typically administered orally and is known for its moderate sedative effects. Its chemical structure includes a dibenzothiazepine core, which is essential for its pharmacological activity. As with any medication, zotepine may have side effects, including weight gain, sedation, and metabolic changes, necessitating careful monitoring during treatment. Overall, zotepine represents a valuable option in the pharmacotherapy of schizophrenia, particularly for patients who may not respond well to other antipsychotic agents.

Formula: C₁₈H₁₈ClNOS

InChI: InChI=1/C18H18ClNOS/c1-20(2)9-10-21-16-11-13-5-3-4-6-17(13)22-18-8-7-14(19)12-15(16)18/h3-8,11-12H,9-10H2,1-2H3

InChI key: InChIKey=HDOZVRUNCMBHFH-UHFFFAOYSA-N

SMILES: O(CCN(C)C)C=1C=2C(SC=3C(C1)=CC=CC3)=CC=C(Cl)C2

Synonyms:

• 2-[(8-Chlorodibenzo[b,f]thiepin-10-yl)oxy]-N,N-dimethylethanamine
• Dibenzo[b,f]thiepin, ethanamine deriv.
• Ethanamine, 2-[(8-chlorodibenzo[b,f]thiepin-10-yl)oxy]-N,N-dimethyl-
• Ethylamine, 2-[(8-chlorodibenzo[b,f]thiepin-10-yl)oxy]-N,N-dimethyl-
• Lodopin
• Losizopilon
• Nipolept
• Setous
• Zoleptil
• Zotepine
• 2-(8-chlorobenzo[b][1]benzothiepin-6-yl)oxy-N,N-dimethyl-ethanamine
• 2-(8-chlorobenzo[b][1]benzothiepin-6-yl)oxyethyl-dimethyl-amine
• 8-Chloro-10-[2-(dimethylamino)ethoxy]dibenzo[b,f]thiepin
• zotepina
• 2-(8-chlorobenzo[b][1]benzothiepin-6-yl)oxy-N,N-dimethylethanamine
• 2-[(8-Chlorodibenzo(Z)[b,f]thiepin-10-yl)oxy]-N,N-dimethylethanamine
• 2-chloro-11-(2-(dimethylamino)ethoxy)dibenzo(b,f)thiepin
• N,N-Dimethyl-2-(2-chlorodibenzo[b,f]thiepin-11-yloxy)ethylamine
• Majorpin
• f)thiepin,2-chloro-11-(2-(dimethylamino)ethoxy)-dibenzo(
• 2-chloro-11-(2-dimethylaminoethoxy)-dibenzo(b,f)thiepine
• 2-[(3-chloro-5-benzo[b][1]benzothiepinyl)oxy]-N,N-dimethylethanamine

Ethanamine, 2-[(8-chlorodibenzo[b,f]thiepin-10-yl)oxy]-N,N-dimethyl-

CAS: 26615-21-4

Formula: C₁₈H₁₈ClNOS

Purity: 98%

Color and Shape: Solid

Molecular weight: 331.8596

Ref: IN-DA002TV2

Zotepine

CAS: 26615-21-4

Formula: C₁₈H₁₈ClNOS

Molecular weight: 331.86

Ref: 7W-GP8521

Zotepine

CAS: 26615-21-4

Zotepine

Purity: ≥98%

Molecular weight: 331.86g/mol

Ref: 54-BUP06427

Zotepine

CAS: 26615-21-4

Formula: C₁₈H₁₈ClNOS

Molecular weight: 331.86

Ref: 4Z-Z-045001

Zotepine

CAS: 26615-21-4

Zotepine, an antipsychotic agent, is a potent antagonist of 5-HT2A, 5-HT2C, Histamine H1, α1-adrenergic, and Dopamine D2 receptors, with Kds of 2.6 nM, 3.2 nM,

Formula: C₁₈H₁₈ClNOS

Purity: 99.78%

Color and Shape: Solid

Molecular weight: 331.86

Ref: TM-T19680

Zotepine-d6

Controlled Product

CAS: 26615-21-4

Stability Toxic
Applications Zotepine-d6, is the labeled analogue of Zotepine (Z700900), an atypical antipsychotic drug used for the treatment of acute and chronic schizophrenia, and acute bipolar mania. It acts as antagonist at dopamine and serotonin receptors. It has a high affinity for the D1 and D2 receptors.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Chan, H, et al.: Psychiat. Clinical Neurosciences 64 (2), 162 (2010); Harada, T., et al.; Clinical Therapeutics 8 (4), 406 (1986);

Formula: C₁₈H₁₂D₆ClNOS

Color and Shape: Light Yellow To Brown

Molecular weight: 337.9

Ref: TR-Z700902

Zotepine

Controlled Product

CAS: 26615-21-4

Antagonist of dopamine (D2), serotonin (5-HT2A) and histamine H1 receptors

Formula: C₁₈H₁₈ClNOS

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 331.86 g/mol

Ref: 3D-FZ37994

Zotepine

Controlled Product

CAS: 26615-21-4

Applications Zotepine, is an atypical antipsychotic drug used for the treatment of acute and chronic schizophrenia, and acute bipolar mania. It acts as antagonist at dopamine and serotonin receptors (1,2). It has a high affinity for the D1 and D2 receptors.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References (1) Chan, H, et al.: Psychiat. Clinical Neurosciences 64 (2), 162 (2010) (2) Harada, T. and Otsuki, S.: Clinical Therapeutics 8 (4), 406 (1986)

Formula: C₁₈H₁₈ClNOS

Color and Shape: White To Light Yellow

Molecular weight: 331.86

Ref: TR-Z700900