CAS 266359-83-5

Repertaxin

Description:

Repertaxin, identified by its CAS number 266359-83-5, is a chemical compound known for its role as a selective antagonist of the chemokine receptor CXCR2. This receptor is involved in various inflammatory processes and is a target for therapeutic intervention in conditions such as chronic obstructive pulmonary disease (COPD) and other inflammatory diseases. Repertaxin exhibits properties that allow it to inhibit the binding of chemokines to CXCR2, thereby modulating the inflammatory response. The compound is characterized by its specific molecular structure, which contributes to its biological activity and selectivity. In terms of physical properties, Repertaxin is typically presented as a solid at room temperature, with solubility in organic solvents. Its pharmacokinetic profile includes considerations of absorption, distribution, metabolism, and excretion, which are crucial for its efficacy and safety in clinical applications. Overall, Repertaxin represents a significant advancement in the development of targeted therapies for inflammatory conditions.

Formula: C₁₄H₂₁NO₃S

InChI: InChI=1S/C14H21NO3S/c1-10(2)9-12-5-7-13(8-6-12)11(3)14(16)15-19(4,17)18/h5-8,10-11H,9H2,1-4H3,(H,15,16)/t11-/m1/s1

InChI key: InChIKey=KQDRVXQXKZXMHP-LLVKDONJSA-N

SMILES: [C@@H](C(NS(C)(=O)=O)=O)(C)C1=CC=C(CC(C)C)C=C1

Synonyms:

• Reparixin
• (αR)-α-Methyl-4-(2-methylpropyl)-N-(methylsulfonyl)benzeneacetamide
• Repertaxin
• Benzeneacetamide, α-methyl-4-(2-methylpropyl)-N-(methylsulfonyl)-, (αR)-
• DF 1681Y

(R)-2-(4-Isobutylphenyl)-N-(Methylsulfonyl)Propanamide

CAS: 266359-83-5

(R)-2-(4-Isobutylphenyl)-N-(Methylsulfonyl)Propanamide

Formula: C₁₄H₂₁NO₃S

Purity: 99%

Molecular weight: 283.39

Ref: 54-OR1023289

Reparixin

CAS: 266359-83-5

Reparixin

Formula: C₁₄H₂₁NO₃S

Purity: ≥98%

Molecular weight: 283.39

Ref: 54-BUP09157

Reparixin

CAS: 266359-83-5

Formula: C₁₄H₂₁NO₃S

Purity: 99%

Color and Shape: Solid

Molecular weight: 283.3864

Ref: IN-DA00BEB1

Reparixin

CAS: 266359-83-5

(R)-2-(4-Isobutylphenyl)-N-(methylsulfonyl)propanamide

Formula: C₁₄H₂₁NO₃S

Purity: 99%

Molecular weight: 283.39

Ref: IN-DG305723

Reparixin

CAS: 266359-83-5

Reparixin inhibits CXCR1 (IC50=1 nM) strongly, CXCR2 weakly (IC50=100 nM), and it's a CXCL8 receptor blocker.

Formula: C₁₄H₂₁NO₃S

Purity: 98% - 99.89%

Color and Shape: Solid

Molecular weight: 283.386

Ref: TM-T4163