CAS 26717-47-5

Clofibride

Description:

Clofibride is a synthetic compound classified as a lipid-regulating agent, primarily used in the treatment of hyperlipidemia. It belongs to the class of fibrates, which are known for their ability to lower triglyceride levels and increase high-density lipoprotein (HDL) cholesterol. The chemical structure of Clofibride features a phenoxyacetic acid moiety, contributing to its pharmacological activity. It is typically administered orally and is absorbed in the gastrointestinal tract, with its effects mediated through the activation of peroxisome proliferator-activated receptors (PPARs). Clofibride is characterized by its moderate solubility in organic solvents and relatively low solubility in water, which influences its bioavailability. The compound has been studied for its potential side effects, including gastrointestinal disturbances and liver function alterations, necessitating monitoring during treatment. Overall, Clofibride represents a significant option in managing lipid disorders, although its use may be limited by the availability of newer agents with improved safety profiles.

Formula: C₁₆H₂₂ClNO₄

InChI: InChI=1S/C16H22ClNO4/c1-16(2,22-13-9-7-12(17)8-10-13)15(20)21-11-5-6-14(19)18(3)4/h7-10H,5-6,11H2,1-4H3

InChI key: InChIKey=CXQGFLBVUNUQIA-UHFFFAOYSA-N

SMILES: O(C(C(OCCCC(N(C)C)=O)=O)(C)C)C1=CC=C(Cl)C=C1

Synonyms:

• Propionic acid, 2-(p-chlorophenoxy)-2-methyl-, ester with 4-hydroxy-N,N-dimethylbutyramide
• Butyramide, 4-hydroxy-N,N-dimethyl-, 2-(p-chlorophenoxy)-2-methylpropionate (ester)
• 4-Hydroxy-N,N-dimethylbutyramide 4-chlorophenoxyisobutyrate
• MG 46
• Propanoic acid, 2-(4-chlorophenoxy)-2-methyl-, 4-(dimethylamino)-4-oxobutyl ester

Clofibride

CAS: 26717-47-5

Clofibrin is a kind of hypolipidemic drug, which can reduce Hypertriglyceride and hypercholesterolemia.

Formula: C₁₆H₂₂ClNO₄

Color and Shape: Solid

Molecular weight: 327.8

Ref: TM-T30977