CAS 26780-50-7

Poly-(DL)-lactide-co-glycolide

Description:

Poly-(DL)-lactide-co-glycolide (PLGA) is a biodegradable copolymer derived from lactic acid and glycolic acid, commonly used in biomedical applications such as drug delivery systems and tissue engineering. Its chemical structure consists of repeating units of lactic acid and glycolic acid, which can be varied in ratio to tailor the polymer's properties. PLGA is characterized by its biocompatibility, biodegradability, and ability to form microspheres or films, making it suitable for controlled release formulations. The degradation rate of PLGA can be adjusted by altering the lactide-to-glycolide ratio, influencing its mechanical properties and release kinetics. Additionally, PLGA is soluble in organic solvents like chloroform and dichloromethane, but insoluble in water, which is advantageous for various formulation techniques. Its applications extend beyond pharmaceuticals to include sutures, scaffolds for tissue regeneration, and other medical devices. Overall, PLGA is a versatile polymer that plays a significant role in advancing drug delivery and regenerative medicine.

Formula: (C₆H₈O₄·C₄H₄O₄)x

InChI: InChI=1S/C6H8O4.C4H4O4/c1-3-5(7)10-4(2)6(8)9-3;5-3-1-7-4(6)2-8-3/h3-4H,1-2H3;1-2H2

InChI key: InChIKey=LCSKNASZPVZHEG-UHFFFAOYSA-N

SMILES: O=C1COC(=O)CO1.CC1C(=O)OC(C)C(=O)O1

Synonyms:

• 5050Dl2A
• Atrigel
• Medisorb
• OsteoScaf
• Poly(D,L-lactide-co-glycolide)
• Poly(DL-lactide-co-glycolide)
• Poly(glycolide-co-lactide)
• Poly(glycolide-lactide)
• Poly(lactide-co-glycolide)
• Poly(lactide-glycolide)
• Poly[(rac-lactide)-co-glycolide]
• Polygalactin
• Polyglactin
• Vicryl
• Glycolide-lactide polymer
• RESOMER RG 503 H
• 1,4-dioxane-2,5-dione - 3,6-dimethyl-1,4-dioxane-2,5-dione (1:1)
• 1,4-Dioxane-2,5-dione, polymer with 3,6-dimethyl-1,4-dioxane-2,5-dione
• p-Dioxane-2,5-dione, polyester with 3,6-dimethyl-p-dioxane-2,5-dione
• 1,4-Dioxane-2,5-dione, 3,6-dimethyl-, polymer with 1,4-dioxane-2,5-dione

PLG 50:50 DLLG 5A (Poly(DL-lactide-co-glycolide) acid terminated (50:50))

CAS: 26780-50-7

Polyesters, saturated, in primary forms, nesoi

Formula: HC₆H₈O₄nC₄H₄O₄nOH

Color and Shape: White Powder

Molecular weight: 54.000-69.000 Da

Ref: 45-1800105

PLG 75:25 DLLG 10A (Poly(DL-lactide-co-glycolide) acid terminated (75:25))

CAS: 26780-50-7

Polyesters, saturated, in primary forms, nesoi

Formula: HC₆H₈O₄nC₄H₄O₄mOH

Ref: 45-1800094

1,4-Dioxane-2,5-dione, polymer with 3,6-dimethyl-1,4-dioxane-2,5-dione

CAS: 26780-50-7

Formula: C₁₀H₁₂O₈

Color and Shape: Solid

Molecular weight: 260.1975

Ref: IN-DA00BE6G

Poly(Dl-Lactide-Glycolide)

CAS: 26780-50-7

Poly(Dl-Lactide-Glycolide)

Purity: Mw 38000-54000

Ref: 54-OR1014706

Poly(Dl-Lactide-Glycolide)

CAS: 26780-50-7

Poly(Dl-Lactide-Glycolide)

Purity: Mw 24000-38000

Ref: 54-OR1014705

Poly(Dl-Lactide-Glycolide)

CAS: 26780-50-7

Poly(Dl-Lactide-Glycolide)

Purity: acid terminated,lactide:glycolide 50:50,Mw 7000-17

Ref: 54-OR1014704

Poly(D,L-lactide-co-glycolide), lactide: glycolide (85:15), average MW 50000 to 75000

CAS: 26780-50-7

Poly(D,L-lactide-co-glycolide) is a synthetic polymer that is used for subcutaneous implantation. It is used to treat incisional hernias and rectoceles in women. Poly(D,L-lactide-co-glycolide) can be implanted in tissues where the natural tissue has been removed or damaged. This polymer has been shown to reduce postoperative pain and improve the quality of life after surgery. Poly(D,L-lactide-co-glycolide) has also been shown to induce neuronal death in rats with experimental spinal cord injury when injected into the injured area. The polymer was injected at two different doses (5% and 10%) and induced significant neuronal death at both doses. Histological analysis showed that the tissue around the injection site had a moderate number of macrophages, but few microglia cells were observed. The presence of macrophages suggests that inflammation may have

Purity: 10 To 20%

Ref: 3D-FP168169

Poly(D,L-lactide-co-glycolide);lactide:glycolide (50:50), MW 54000-69000Da

CAS: 26780-50-7

Poly(D,L-lactide-co-glycolide) is a biocompatible polymer that has been shown to be resistant to bacterial infections. It is a multivariate logistic regression analysis that shows the material's resistance to growth factor-β1 and neuronal death. The polymer has a low carcinogenic potential and toxicity studies have shown it is safe for use in humans. This polymer has been used in an experimental model of chronic oral toxicity and was shown to be biocompatible with human serum.

Formula: (C₆H₈O₄·C₄H₄O₄)x

Purity: Min. 95%

Color and Shape: Powder

Ref: 3D-FP180578

Poly(D,L-lactide-co-glycolide - lactide:glycolide (50:50), average MW 7000-17000Da

CAS: 26780-50-7

Poly(D,L-lactide-co-glycolide - lactide:glycolide (50:50), average MW 7000-17000Da (PLGA) is a biocompatible polymer that has been shown to have high resistance to infectious diseases and the potential for use in biomedical applications. The polymer is often used as a drug carrier molecule and has been shown to inhibit the growth of human breast cancer cells. It also has been shown to inhibit neuronal death. PLGA stimulates the production of basic fibroblast growth factor (bFGF) which may promote wound healing and tissue regeneration. PLGA is also used in radiation therapy because it does not produce any harmful byproducts when irradiated with ionizing radiation. Toxicity studies have found that PLGA does not produce any toxicity when irradiated with ionizing radiation as well as untreated controls.

Purity: Min. 95%

Color and Shape: Powder

Ref: 3D-FP180577

Poly(D,L-lactide-co-glycolide), lactide: glycolide (50:50), average MW 10000 to 15000

CAS: 26780-50-7

Poly(D,L-lactide-co-glycolide) is a biodegradable polymer with a low melting point. It has been used in the form of sutures for surgical procedures and has also been shown to be effective against staphylococcus. Poly(D,L-lactide-co-glycolide) also has an effect on neuronal death and incisional wound healing. The polymer can be degraded by hydrolysis or enzymatic cleavage and is therefore not suitable as an implant material. This material is used in the form of films for drug delivery systems as well as in surgical meshes for hernia repair, abdominal wall hernias, and rectocele repair.

Formula: (C₆H₈O₄•C₄H₄O₄)x

Purity: Min. 95%

Ref: 3D-FP165618

Poly(D,L-lactide-co-glycolide) - lactide: glycolide (90:10), average MW 10000 to 15000

CAS: 26780-50-7

Poly(D,L-lactide-co-glycolide) is a biodegradable polymer that is used in the manufacture of sutures. It is made from the monomers L-lactide and glycolide and has an average molecular weight of 10,000 to 15,000 Daltons. Poly(D,L-lactide-co-glycolide) can be sterilized by autoclaving or gamma irradiation. The polymerization process does not produce any toxic byproducts. Polymers are soluble in solvents such as acetic acid or alcohols. They are also resistant to degradation by enzymes or bacteria. This polymer is used in the manufacturing of sutures because it has good adhesive properties and is more water resistant than other polymers. Poly(D,L-lactide-co-glycolide) can be used as an ophthalmic device because it is transparent and biocompatible with

Formula: C₃H₄O₂xC₂H₂O₂y

Purity: Min. 95%

Ref: 3D-FP165619

Poly(D,L-lactide-co-glycolide) - lactide: glycolide (75:25), average MW 10000 to 15000

CAS: 26780-50-7

Poly (DL-lactide-co-glycolide) is a biodegradable polymer that is used in the manufacture of medical devices. It is made from lactic acid and glycolic acid. Poly (DL-lactide-co-glycolide) can degrade by hydrolysis to produce lactic acid and glycolic acid, which are both naturally occurring substances in the body. This polymer has been shown to be effective in treating staphylococcal infections, such as rectoceles. A predictive factor for treatment success with poly (DL-lactide-co-glycolide) is the morphology of the rectocele before surgery. In this study, multivariate logistic regression was used to analyze preoperative factors that predicted treatment success with poly (DL-lactide-co-glycolide). The results showed that women who had an incisional rectocele were more likely to have a successful outcome when treated

Formula: C₃H₄O₂xC₂H₂O₂y

Purity: Min. 95%

Ref: 3D-FP165617

Poly(D,L-lactide-co-glycolide) - lactide: glycolide (75:25), average MW 50000 to 75000

CAS: 26780-50-7

Poly (D,L-lactide-co-glycolide) is a synthetic polymer that consists of 75% lactide and 25% glycolide. It has been used in the treatment of incisional hernia, which is a type of hernia that occurs when an organ protrudes through an incision made in the abdominal wall. Poly (D,L-lactide-co-glycolide) has also been used to prevent neuronal death in experimental animals. Histological analysis of the subcutaneous tissue showed significantly less neuronal death with poly (D,L-lactide-co-glycolide). This polymer has also been shown to be effective for women with rectocele and was found to be safe for use in this population. Poly (D,L-lactide-co-glycolide) is a synthetic polymer consisting primarily of 75% lactides and 25% glycolides. This polymer has been used as an

Formula: C₃H₄O₂xC₂H₂O₂y

Purity: Min. 95%

Color and Shape: White Powder

Ref: 3D-FP45267

PLG 50:50 DLLG 3A (Poly(DL-lactide-co-glycolide) acid terminated (50:50))

CAS: 26780-50-7

Polyesters, saturated, in primary forms, nesoi

Formula: HC₆H₈O₄nC₄H₄O₄nOH

Color and Shape: White Powder

Molecular weight: 24.000-38.000 Da

Ref: 45-1800102

PLG 75:25 DLLG 3A (Poly(DL-lactide-co-glycolide) acid terminated (75:25))

CAS: 26780-50-7

Polyesters, saturated, in primary forms, nesoi

Formula: HC₆H₈O₄nC₄H₄O₄mOH

Ref: 45-1800096

Poly-(DL)-lactide-co-glycolide

CAS: 26780-50-7

Formula: C₈H₁₄O₄

Molecular weight: 174.20

Ref: 4Z-L-159006