CAS 26788-23-8

4-Methoxyestradiol

Description:

4-Methoxyestradiol is a synthetic derivative of estradiol, a naturally occurring estrogen. It is characterized by the presence of a methoxy group at the 4-position of the estradiol structure, which influences its biological activity. This compound is known for its potential anti-cancer properties, particularly in inhibiting the growth of certain tumors and modulating angiogenesis, the formation of new blood vessels. 4-Methoxyestradiol exhibits a range of biological effects, including anti-inflammatory and anti-proliferative activities, making it a subject of interest in cancer research and therapeutic applications. Additionally, it has been studied for its role in cardiovascular health and bone density regulation. The compound is typically administered in research settings and is not widely used in clinical practice. Its safety profile and pharmacokinetics are still under investigation, and further studies are needed to fully understand its mechanisms of action and potential therapeutic benefits. As with any chemical substance, proper handling and safety precautions are essential due to its biological activity.

Formula: C₁₉H₂₆O₃

InChI: InChI=1S/C19H26O3/c1-19-10-9-12-11-5-7-16(20)18(22-2)14(11)4-3-13(12)15(19)6-8-17(19)21/h5,7,12-13,15,17,20-21H,3-4,6,8-10H2,1-2H3/t12-,13-,15+,17+,19+/m1/s1

InChI key: InChIKey=BCWZIZLVBYHFES-PYEWSWHRSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@](C=4C(CC3)=C(OC)C(O)=CC4)(CC1)[H])[H])(CC[C@@H]2O)[H]

Synonyms:

• (17β)-4-Methoxyestra-1,3,5(10)-triene-3,17-diol
• 4-Methoxy-17β-estradiol
• 4-Methoxyestradiol
• Estra-1,3,5(10)-triene-3,17-diol, 4-methoxy-, (17beta)-
• Estra-1,3,5(10)-triene-3,17-diol, 4-methoxy-, (17β)-
• Estra-1,3,5(10)-triene-3,17β-diol, 4-methoxy-

4-Methoxy 17β-Estradiol

CAS: 26788-23-8

4-Methoxy-17-estradiol is one of the estrogen metabolites and a methylation metabolite of 4-hydroxyestradiol.

Formula: C₁₉H₂₆O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 302.41

Ref: TM-T9456

4-Methoxy-17β-estradiol-1,2,16,16,17-d5

CAS: 26788-23-8

Purity: 98 atom % D

Color and Shape: White Solid

Molecular weight: 307.44

Ref: 3U-D6057

4-Methoxy 17β-Estradiol

CAS: 26788-23-8

Applications A metabolite of 17β-Estradiol.
References Cushman, M., et al.: J. Med. Chem., 38, 2041 (1995), D’Amato, R.J., et al.: Proc. Natl. Acad. Sci. USA, 91, 3964 (1994), Forsis, T., et al.: Nature, 368, 237 (1994)

Formula: C₁₉H₂₆O₃

Color and Shape: Neat

Molecular weight: 302.41

Ref: TR-M262630

4-Methoxy 17b-estradiol

Controlled Product

CAS: 26788-23-8

4-Methoxy 17β-estradiol is a synthetic estrogen that is used as a pharmaceutical drug in the treatment of menopausal symptoms and to prevent osteoporosis. It can be taken orally or administered by injection. 4-Methoxy 17β-estradiol has been found to have interactive effects with other drugs, such as fatty acids and catechol-o-methyltransferase (COMT). It also has an effect on body mass index in vivo, which can lead to cancerous cell proliferation. The matrix effect of 4-methoxy 17β-estradiol on tissues depends on the hydrogen bonds it forms with amino acids in the protein matrix. The hydrogen bonds are different for each tissue type and this may contribute to the differences in carcinogenic potential between tissues. This drug is not active against MCF-7 human breast cancer cells, but does inhibit growth of MDA MB 231 human breast cancer cells.

Formula: C₁₉H₂₆O₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 302.41 g/mol

Ref: 3D-FM25169

4-Methoxy 17β-Estradiol-16,16,17-d3

Controlled Product

CAS: 26788-23-8

Formula: C₁₉D₃H₂₃O₃

Color and Shape: Neat

Molecular weight: 305.426

Ref: TR-M262633

4-Methoxy-17β-estradiol-1,2,16,16,17-d5

Controlled Product

CAS: 26788-23-8

Applications 4-Methoxy-17beta-estradiol-1,2,16,16,17-d5 is a useful isotopically labeled compound of 4-Methoxy 17β-Estradiol (M262630)

Formula: C₁₉H₂₁D₅O₃

Color and Shape: Neat

Molecular weight: 307.44

Ref: TR-M262631

4-Methoxyestradiol

CAS: 26788-23-8

Formula: C₁₉H₂₆O₃

Molecular weight: 302.41

Ref: ST-EA-CP-E28042