CAS 26833-85-2

Harringtonine

Description:

Harringtonine is a natural alkaloid derived from the plant species Cephalotaxus harringtonia, commonly known as the Japanese plum yew. It is classified as a potent inhibitor of protein synthesis, specifically targeting the eukaryotic ribosome. Harringtonine exhibits antitumor properties and has been studied for its potential use in treating various types of cancer, particularly acute myeloid leukemia. The compound is known for its ability to induce apoptosis in cancer cells, making it a subject of interest in cancer research. In terms of its chemical structure, Harringtonine features a complex polycyclic framework, which contributes to its biological activity. It is typically administered intravenously due to its poor oral bioavailability. As with many alkaloids, Harringtonine may exhibit side effects, and its use is often accompanied by careful monitoring in clinical settings. Overall, Harringtonine represents a significant compound in the field of medicinal chemistry, particularly in the development of novel anticancer therapies.

Formula: C₂₈H₃₇NO₉

InChI: InChI=1S/C28H37NO9/c1-26(2,32)8-9-28(33,15-22(30)35-4)25(31)38-24-21(34-3)14-27-7-5-10-29(27)11-6-17-12-19-20(37-16-36-19)13-18(17)23(24)27/h12-14,23-24,32-33H,5-11,15-16H2,1-4H3/t23-,24-,27+,28-/m1/s1

InChI key: InChIKey=HAVJATCHLFRDHY-KSZYUSJVSA-N

SMILES: O(C([C@@](CCC(C)(C)O)(CC(OC)=O)O)=O)[C@H]1[C@@]2([C@@]3(N(CCC=4C2=CC5=C(C4)OCO5)CCC3)C=C1OC)[H]

Synonyms:

• (4alpha)-O~3~-[(2S)-2,5-dihydroxy-2-(2-methoxy-2-oxoethyl)-5-methylhexanoyl]cephalotaxine
• 2'R-Harringtonine
• 2′R-Harringtonine
• 4H-Cyclopenta[a][1,3]dioxolo[4,5-h]pyrrolo[2,1-b][3]benzazepine, cephalotaxine deriv.
• Alkaloid C from cephalotaxus
• Cephalotaxine, 3-[4-methyl (2R)-2-hydroxy-2-(3-hydroxy-3-methylbutyl)butanedioate]
• Cephalotaxine, 4-methyl (2R)-2-hydroxy-2-(3-hydroxy-3-methylbutyl)butanedioate (ester)
• Cephalotaxine, 4-methyl-, 2-hydroxy-2-(3-hydroxy-3-methylbutyl)butanedioate (ester), (3(R))-
• Harringtonin
• Nsc 124147
• O~3~-[(2R)-2,5-dihydroxy-2-(2-methoxy-2-oxoethyl)-5-methylhexanoyl]cephalotaxine
• Harringtonine
• 2-Hydroxy-2-(3-hydroxy-3-methylbutyl)butanedioic acid 1-[(3R)-3-deoxycephalotaxin-3-yl]4-methyl ester
• 2’R-Harringtonine,Harringtonin
• Cephalotaxine, 4-methyl 2-hydroxy-2-(3-hydroxy-
• 3-[4-Methyl (2R)-2-hydroxy-2-(3-hydroxy-3-Methylbutyl)butanedioate]cephalotaxine
• cephalotaxine,4-methyl(2r)-2-hydroxy-2-(3-hydroxy-3-methylbutyl)butanedioat
• HARRINGTONINE(P) USP/EP/BP
• nsc124147
• (3(r))-ter
• 3-methylbutyl)butanedioate (ester), [3(R)]-
• Harringtonine, 98%, from Taxus chinensis (Pilg.) Rehder
• 4-methyl-cephalotaxin2-hydroxy-2-(3-hydroxy-3-methylbutyl)butanedioate(es
• alkaloidcfromcephalotaxus
• HARRINGTONINE98%,99%
• Harringtonine 26833-85-2

Harringtonine

CAS: 26833-85-2

Harringtonine

Purity: ≥98%

Molecular weight: 531.59g/mol

Ref: 54-BUP04833

Harringtonine

CAS: 26833-85-2

Formula: C₂₈H₃₇NO₉

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 531.59

Ref: 7W-GP3260

Harringtonine

CAS: 26833-85-2

Formula: C₂₈H₃₇NO₉

Purity: 95%~99%

Molecular weight: 531.602

Ref: BP-BP0703

Harringtonine

CAS: 26833-85-2

Harringtonine is a natural alkaloid that inhibitsprotein synthesis. Harringtonine has antitumor and antiviral activities. Cost-effective and quality-assured.

Formula: C₂₈H₃₇NO₉

Purity: 98.62% - 98.94%

Color and Shape: White Solid

Molecular weight: 531.59

Ref: TM-T8286

Harringtonin

Controlled Product

CAS: 26833-85-2

Applications A natural product with significant antitumor activities.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Sah, N., et al.: J. Biol. Chem., 278, 20593 (2003), Lu, D., et al.: J. Int. Med. Res., 32, 488 (2004), Yunmbam, M., et al.: Oncol. Rep., 11, 833 (2004), Shao, S., et al.: Cell Biol. Int., 32, 893 (2008),

Formula: C₂₈H₃₇NO₉

Color and Shape: Neat

Molecular weight: 531.59

Ref: TR-H105285

Harringtonine

CAS: 26833-85-2

Harringtonine is a plant-derived alkaloid, which is isolated from the seeds of the Cephalotaxus species. It functions primarily by inhibiting protein synthesis within eukaryotic cells, targeting the elongation step of translation. Harringtonine binds to the ribosomal A-site cleft, halting the proper addition of amino acids to the growing polypeptide chain and thereby inducing apoptosis in rapidly dividing cells.

Formula: C₂₈H₃₇NO₉

Purity: Min. 95%

Color and Shape: White Off-White Powder

Molecular weight: 531.59 g/mol

Ref: 3D-FH15975

Harringtonin

CAS: 26833-85-2

Formula: C₂₈H₃₇NO₉

Color and Shape: Solid

Molecular weight: 531.5947

Ref: IN-DA0037GY