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CAS 26839-75-8

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Timolol

Description:
Timolol is a non-selective beta-adrenergic antagonist primarily used in the treatment of glaucoma and hypertension. It is characterized by its ability to reduce intraocular pressure by decreasing aqueous humor production in the eye, making it effective in managing conditions like open-angle glaucoma. Chemically, Timolol is a white to off-white crystalline powder that is soluble in water and has a relatively low molecular weight. Its structure includes a naphthyl moiety and a propanolamine side chain, which contribute to its pharmacological activity. Timolol is typically administered in the form of eye drops or orally, depending on the condition being treated. The drug's pharmacokinetics involve extensive hepatic metabolism, and it exhibits a half-life that allows for once or twice daily dosing. Side effects may include bradycardia, hypotension, and respiratory issues, particularly in patients with pre-existing conditions. Overall, Timolol is a well-established medication with a significant role in cardiovascular and ophthalmic therapies.
Formula:C13H24N4O3S
InChI:InChI=1S/C13H24N4O3S/c1-13(2,3)14-8-10(18)9-20-12-11(15-21-16-12)17-4-6-19-7-5-17/h10,14,18H,4-9H2,1-3H3/t10-/m0/s1
InChI key:InChIKey=BLJRIMJGRPQVNF-JTQLQIEISA-N
SMILES:O(C[C@H](CNC(C)(C)C)O)C=1C(=NSN1)N2CCOCC2
Synonyms:
  • (-)-S-Timolol
  • (-)-Timolol
  • (2S)-1-(tert-Butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol
  • (2S)-1-(tert-Butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol
  • (2S)-1-[(1,1-Dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-2-propanol
  • (S)-1-(terc-butilamino)-3-[(4-morfolino-1,2,5-tiadiazol-3-il)oxi]propan-2-ol
  • (S)-1-(tert-Butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol
  • (S)-1-(tert-butylamino)-3-[(4-morpholino-1,2,5-thiadiazole-3-yl)oxy]propane-2-ol
  • 1,2,5-Thiadiazole, 2-propanol deriv.
  • 2-Propanol, 1-(tert-butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]-, (S)-(-)-
  • See more synonyms
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Found 4 products.