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CAS 26839-77-0

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(+)-Timolol maleate

Description:
(+)-Timolol maleate is a pharmaceutical compound primarily used as a non-selective beta-adrenergic antagonist, commonly prescribed for the treatment of glaucoma and hypertension. It is a salt formed from timolol, a beta-blocker, and maleic acid. The substance appears as a white to off-white crystalline powder, which is soluble in water and exhibits a pH range that is typically neutral. Its molecular structure includes a naphthyl moiety, contributing to its pharmacological activity. (+)-Timolol maleate works by reducing intraocular pressure in glaucoma patients by decreasing aqueous humor production. Additionally, it has systemic effects, such as lowering heart rate and blood pressure, making it useful in treating cardiovascular conditions. The compound is characterized by its stereochemistry, with the (+) designation indicating its specific optical activity. As with many pharmaceuticals, it is essential to consider its dosage, potential side effects, and contraindications when prescribing or using this medication.
Formula:C13H24N4O3S·C4H4O4
InChI:InChI=1/C13H24N4O3S.C4H4O4/c1-13(2,3)14-8-10(18)9-20-12-11(15-21-16-12)17-4-6-19-7-5-17;5-3(6)1-2-4(7)8/h10,14,18H,4-9H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
SMILES:O(C[C@@H](CNC(C)(C)C)O)C=1C(=NSN1)N2CCOCC2.C(=C\C(O)=O)\C(O)=O
Synonyms:
  • (+)-3-(3-tert-Butylamino-2-hydroxypropoxy)-4-morpholino-1,2,5-thiadiazole hydrogen maleate
  • (+)-3-[3-(Tert-Butylamino)-2-Hydroxypropoxy]-4-Morpholino-1,2,5-Thiadiazole Maleate
  • (-)-1-(tert-Butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)-2-propanol maleate
  • (R)-(+)-Timolol maleate
  • (R)-Timolol hydrogen maleate
  • 1,2,5-Thiadiazole, 2-propanol deriv.
  • 1-(tert-Butylamino)-3-{[4-(morpholin-4-yl)-1,2,5-thiadiazol-3-yl]oxy}propan-2-ol (2Z)-but-2-enedioate (1:1)
  • 1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol (2Z)-but-2-enedioate (salt)
  • 2-Propanol, 1-(tert-butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]-, (+)-, maleate (1:1) (salt), (-)-
  • 2-Propanol, 1-[(1,1-dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-, (2R)-, (2Z)-2-butenedioate (1:1)
  • See more synonyms
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