DHODH-IN-18, identified by its CAS number 2685799-97-5, is a chemical compound that serves as an inhibitor of dihydroorotate dehydrogenase (DHODH), an enzyme involved in the de novo synthesis of pyrimidines. This compound is of interest in medicinal chemistry, particularly for its potential therapeutic applications in treating various diseases, including autoimmune disorders and certain cancers. DHODH-IN-18 is characterized by its specific structural features that allow it to bind effectively to the active site of the enzyme, thereby disrupting its function. The inhibition of DHODH can lead to a decrease in the proliferation of rapidly dividing cells, making it a target for drug development. Additionally, the compound's solubility, stability, and bioavailability are important factors that influence its efficacy and safety profile in biological systems. As research continues, further studies are likely to elucidate its pharmacokinetics, mechanism of action, and potential side effects, contributing to the understanding of its role in therapeutic contexts.

DHODH-IN-18

2685799-97-5: DHODH-IN-18, identified by its CAS number 2685799-97-5, is a chemical compound that serves as an inhibitor of dihydroorotate dehydrogenase (DHODH), an enzyme involved in the de novo synthesis of pyrimidines. This compound is of interest in medicinal chemistry, particularly for its potential therapeutic applications in treating various diseases, including autoimmune disorders and certain cancers. DHODH-IN-18 is characterized by its specific structural features that allow it to bind effectively to the active site of the enzyme, thereby disrupting its function. The inhibition of DHODH can lead to a decrease in the proliferation of rapidly dividing cells, making it a target for drug development. Additionally, the compound's solubility, stability, and bioavailability are important factors that influence its efficacy and safety profile in biological systems. As research continues, further studies are likely to elucidate its pharmacokinetics, mechanism of action, and potential side effects, contributing to the understanding of its role in therapeutic contexts.

<p>DHODH-IN-18 is a human DHODH inhibitor ( IC 50 = 0.2 nM).</p>

CAS 2685799-97-5

DHODH-IN-18

DHODH-IN-18

Ref: TM-T40309