CAS 26894-49-5

alternariol monomethyl ether from*alternaria alte

Description:

Alternariol monomethyl ether (AME) is a mycotoxin produced by the fungus Alternaria alternata, which is commonly found in various plants and agricultural products. This compound is characterized by its chemical structure, which includes a phenolic moiety and a methoxy group, contributing to its biological activity. AME exhibits cytotoxic and genotoxic properties, making it a subject of interest in toxicology and food safety studies. It is soluble in organic solvents, which facilitates its extraction from contaminated materials. The compound has been detected in a variety of food products, particularly fruits and vegetables, raising concerns about its potential health effects when consumed. Research indicates that AME may have implications for human health, particularly in relation to its carcinogenic potential. As a result, monitoring and regulation of this mycotoxin in food supplies are important to mitigate risks associated with exposure. Overall, alternariol monomethyl ether serves as a significant example of the impact of fungal metabolites on food safety and public health.

Formula: C₁₅H₁₂O₅

Alternariol monomethyl ether

CAS: 26894-49-5

Formula: C₁₅H₁₂O₅

Molecular weight: 272.25

Ref: 7W-GA2124

Alternariol monomethyl ether

CAS: 26894-49-5

Alternariol is a natural compound that has been found to be structurally similar to the chemotherapeutic drug taxol. It has been shown to have significant cytotoxicity against tumor cells in vitro and in vivo, with no toxicity to normal cells. Alternariol has also been shown to inhibit HIV replication in cell cultures and animal models. Structural analysis of alternariol revealed that it binds to the matrix effect region of the viral reverse transcriptase protein, which is essential for its enzymatic activity. Alternariol monomethyl ether (AME) is a metabolite of alternariol, which can be detected in mouse plasma following administration of AME. AME was also shown to be active against murine hepatoma cells and other cancer cell lines, but not against normal cells.

Formula: C₁₅H₁₂O₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 272.25 g/mol

Ref: 3D-FA17331

Alternariol Monomethyl Ether-d3

Controlled Product

CAS: 26894-49-5

Stability Hygroscopic
Applications Alternariol Monomethyl Ether-d3 is labelled methyl este analog fo Alternariol. An alternaria mycotoxin and genotoxin, found in common edible crops. It inhibits the activity of various DNA-topoisomerases, increasing the rate of DNA strand breaks.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Asam, S., et al.: J. Agric. Food Chem., 57, 5152 (2009); Fehr, M., et al.: Mol. Nut. Food Res., 53, 441 (2009); Tiemann, U., et al.: Toxicol. Lett., 186, 139 (2009);

Formula: C₁₅D₃H₉O₅

Color and Shape: Neat

Molecular weight: 275.2713

Ref: TR-A575771

Alternariol Monomethyl Ether

Controlled Product

CAS: 26894-49-5

Stability Hygroscopic
Applications An alternaria mycotoxin and genotoxin, found in common edible crops. It inhibits the activity of various DNA-topoisomerases, increasing the rate of DNA strand breaks.
References Asam, S., et al.: J. Agric. Food Chem., 57, 5152 (2009); Fehr, M., et al.: Mol. Nut. Food Res., 53, 441 (2009); Tiemann, U., et al.: Toxicol. Lett., 186, 139 (2009);

Formula: C₁₅H₁₂O₅

Color and Shape: Neat

Molecular weight: 272.253

Ref: TR-A575770