CAS 26921-17-5
:Timolol maleate
Description:
Timolol maleate is a non-selective beta-adrenergic antagonist primarily used in the treatment of glaucoma and ocular hypertension, as well as for systemic conditions such as hypertension and certain types of heart disease. It is a white to off-white crystalline powder that is soluble in water and has a pH range that is typically neutral. The substance is a salt formed from timolol, a beta-blocker, and maleic acid, which enhances its solubility and stability. Timolol maleate works by reducing intraocular pressure through decreased aqueous humor production in the eye. Its pharmacological effects include lowering heart rate and myocardial contractility, making it useful in managing cardiovascular conditions. The compound is generally well-tolerated, though it may cause side effects such as fatigue, dizziness, or respiratory issues in some patients. Due to its systemic effects, caution is advised in patients with respiratory conditions or certain cardiovascular disorders. Overall, timolol maleate is an important therapeutic agent in both ophthalmology and cardiology.
Formula:C13H24N4O3S·C4H4O4
InChI:InChI=1/C13H24N4O3S.C4H4O4/c1-13(2,3)14-8-10(18)9-20-12-11(15-21-16-12)17-4-6-19-7-5-17;5-3(6)1-2-4(7)8/h10,14,18H,4-9H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t10-;/m1./s1
SMILES:O(C[C@H](CNC(C)(C)C)O)C=1C(=NSN1)N2CCOCC2.C(=C\C(O)=O)\C(O)=O
Synonyms:- (-)-Timolol maleate
- (2R)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol (2Z)-but-2-enedioate (salt)
- (2R)-1-(tert-butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol
- (2S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol (2Z)-but-2-enedioate (salt)
- (S)-Timolol hydrogen maleate
- (S)-[1-(1,1dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-2-propanol maleate
- 1,2,5-Thiadiazole, 2-propanol deriv.
- 2-Propanol, 1-(tert-butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]-, (-)-, maleate (1:1) (salt)
- 2-Propanol, 1-[(1,1-dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-, (2S)-, (2Z)-2-butenedioate (1:1)
- 2-Propanol, 1-[(1,1-dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-, (2S)-, (2Z)-2-butenedioate (1:1) (salt)
- 2-Propanol, 1-[(1,1-dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-, (S)-, (Z)-2-butenedioate (1:1) (salt)
- <span class="text-smallcaps">L</span>-Timolol maleate
- Apimol
- Aquanil
- Betim
- Betime
- Blocadren
- Blocanol
- But-2-Enedioic Acid
- Isralol
- Istalol
- Mk 950
- Ocumol
- Ophtamolol
- Optimol
- Proflax
- Rysmon TG
- Temserin
- Tenopt
- Timabak
- Timacar
- Timacor
- Timoftol
- Timohexal
- Timolast
- Timolet
- Timolol LA
- Timolol hydrogen maleate
- Timomann
- Timoptic
- Timoptol
- Timoptol XE
- Timoptol-LA
- Timorom
- Wp 934
- See more synonyms
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Found 17 products.
Timolol Maleate
CAS:Formula:C13H24N4O3S·C4H4O4Purity:>98.0%(T)(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:432.49TIMOLOL MALEATE CRS
CAS:<p>TIMOLOL MALEATE CRS</p>Formula:C17H28N4O7SColor and Shape:Added ModifiedMolecular weight:432.4918Timolol maleate
CAS:Timolol maleateFormula:C13H24N4O3SC4H4O4Purity:100.0%Color and Shape:White. To. Off-WhiteMolecular weight:432.16787TIMOLOL FOR SYSTEM SUITABILITY CRS
CAS:<p>TIMOLOL FOR SYSTEM SUITABILITY CRS</p>Formula:C17H28N4O7SMolecular weight:432.4918Timolol Maleate
CAS:Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoiFormula:C13H24N4O3S·C4H4O4Color and Shape:White PowderMolecular weight:432.16787Timolol Maleate
CAS:Formula:C13H24N4O3S·C4H4O4Color and Shape:White To Off-White SolidMolecular weight:316.42 116.07Timolol maleate salt
CAS:Formula:C13H24N4O3S·C4H4O4Purity:(Titration) 98.0 - 101.0 % (dried basis)Color and Shape:White to almost white powder or crystalsMolecular weight:432.49Timolol Maleate
CAS:Controlled ProductFormula:C13H24N4O3S·C4H4O4Color and Shape:NeatMolecular weight:432.49Timolol hydrogenmaleate
CAS:Controlled ProductFormula:C13H24N4O3S·C4H4O4Color and Shape:NeatMolecular weight:432.49(S)-Timolol-d5
CAS:Formula:C13H19D5N4O3SColor and Shape:White To Off-White SolidMolecular weight:321.45Timolol Maleate
CAS:<p>Applications Antihypertensive; antiarrhythmic (class II); antianginal; antiglaucoma agent.<br>References Wasson, et al.: J. Med. Chem., 15, 651 (1972), Franciosa, et al.: Clin. Pharmacol. Ther., 13, 138 (1972), Heel, R.C., et al.: Drugs, 17, 38 (1979), Rofman, B.A., et al.: Hypertension, 2, 643 (1980), Mazzo, D.J., et al.: Anal. Profiles Drug Subs., 16, 641 (1987),<br></p>Formula:C13H24N4O3S·C4H4O4Color and Shape:NeatMolecular weight:432.49S-Timolol maleate
CAS:Controlled Product<p>S-Timolol maleate is a cardioselective beta blocker that has been shown to lower the diastolic pressure and improve the function of the heart. S-Timolol maleate inhibits the enzyme that converts hydrogen ions into hydroxyl ions, which are necessary for the conversion of fatty acids to energy. It also reduces cardiac rate and blood pressure by inhibiting the transmission of nerve impulses. This drug has been shown to be effective in treating anginal attacks, ventricular dysfunction, and cardiac arrhythmias. S-Timolol maleate also slows down metabolic reactions in cells, which increases resistance to thermal expansion.</p>Formula:C13H24N4O3S·C4H4O4Purity:Min. 95%Color and Shape:White Off-White PowderMolecular weight:432.49 g/molS-Timolol maleate - Bio-X ™
CAS:Controlled Product<p>Timolol is an ophthalmic beta-adrenergic blocker that is used to lower the intraocular pressure in patients with glaucoma. It is also used to treat hypertension, as well as other conditions, such as arrhythmias, thyrotoxicosis and angina pectoris. The drug acts by blocking β1-receptors on the surface of heart muscle cells and blood vessels, thereby reducing the workload on the heart and lowering blood pressure.</p>Formula:C13H24N4O3S•C4H4O4Purity:Min. 95%Color and Shape:PowderMolecular weight:432.49 g/mol
