CAS 26921-17-5: Timolol maleate
Description:Timolol maleate is a non-selective beta-adrenergic antagonist primarily used in the treatment of glaucoma and ocular hypertension, as well as for systemic conditions such as hypertension and certain types of heart disease. It is a white to off-white crystalline powder that is soluble in water and has a pH range that is typically neutral. The substance is a salt formed from timolol, a beta-blocker, and maleic acid, which enhances its solubility and stability. Timolol maleate works by reducing intraocular pressure through decreased aqueous humor production in the eye. Its pharmacological effects include lowering heart rate and myocardial contractility, making it useful in managing cardiovascular conditions. The compound is generally well-tolerated, though it may cause side effects such as fatigue, dizziness, or respiratory issues in some patients. Due to its systemic effects, caution is advised in patients with respiratory conditions or certain cardiovascular disorders. Overall, timolol maleate is an important therapeutic agent in both ophthalmology and cardiology.
Formula:C13H24N4O3S·C4H4O4
InChI:InChI=1/C13H24N4O3S.C4H4O4/c1-13(2,3)14-8-10(18)9-20-12-11(15-21-16-12)17-4-6-19-7-5-17;5-3(6)1-2-4(7)8/h10,14,18H,4-9H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t10-;/m1./s1
SMILES:O=C(O)C=CC(=O)O.OC(COC1=NSN=C1N2CCOCC2)CNC(C)(C)C
- Synonyms:
- (-)-Timolol maleate
- (2R)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol (2Z)-but-2-enedioate (salt)
- (2R)-1-(tert-butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol
- (2S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol (2Z)-but-2-enedioate (salt)
- (S)-Timolol hydrogen maleate
- (S)-[1-(1,1dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-2-propanol maleate
- 1,2,5-Thiadiazole, 2-propanol deriv.
- 2-Propanol, 1-(tert-butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]-, (-)-, maleate (1:1) (salt)
- 2-Propanol, 1-[(1,1-dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-, (2S)-, (2Z)-2-butenedioate (1:1)
- 2-Propanol, 1-[(1,1-dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-, (2S)-, (2Z)-2-butenedioate (1:1) (salt)
- See more synonyms
- 2-Propanol, 1-[(1,1-dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-, (S)-, (Z)-2-butenedioate (1:1) (salt)
- <span class="text-smallcaps">L</span>-Timolol maleate
- Apimol
- Aquanil
- Betim
- Betime
- Blocadren
- Blocanol
- But-2-Enedioic Acid
- Isralol
- Istalol
- Mk 950
- Ocumol
- Ophtamolol
- Optimol
- Proflax
- Rysmon TG
- Temserin
- Tenopt
- Timabak
- Timacar
- Timacor
- Timoftol
- Timohexal
- Timolast
- Timolet
- Timolol LA
- Timolol hydrogen maleate
- Timomann
- Timoptic
- Timoptol
- Timoptol XE
- Timoptol-LA
- Timorom
- Wp 934
- l-Timolol maleate
