CAS 26936-41-4

5′-Inosinic acid, homopolymer, potassium salt

Description:

5′-Inosinic acid, homopolymer, potassium salt, commonly referred to as potassium inosinate, is a nucleotide derivative that serves as a key component in various biochemical processes. This substance is a polymer of inosinic acid, which is a nucleotide that plays a crucial role in cellular metabolism and energy transfer. As a potassium salt, it is soluble in water, making it useful in various applications, including food additives and flavor enhancers due to its umami taste. The polymeric nature of this compound allows it to exhibit unique properties, such as improved stability and bioavailability compared to its monomeric counterparts. In addition to its culinary uses, potassium inosinate is also studied for its potential health benefits, including its role in promoting cellular function and its antioxidant properties. Its safety profile is generally considered favorable, although, like any additive, it should be consumed within recommended limits. Overall, 5′-Inosinic acid, homopolymer, potassium salt is a versatile compound with significant applications in both food science and biochemistry.

Formula: C₁₀H₁₂KN₄O₈P

InChI: InChI=1S/C10H13N4O8P.K/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17;/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20);/t4-,6-,7-,10-;/m1./s1

InChI key: InChIKey=JQHFBTAQMFUUKS-MCDZGGTQSA-N

SMILES: O[C@H]1[C@H](N2C3=C(N=C2)C(=O)N=CN3)O[C@H](COP(=O)(O)O)[C@H]1O.[K]

Synonyms:

• 5′-Inosinic acid, homopolymer, potassium salt
• 5′-Inosinic acid, polymers, potassium salt
• PolyI potassium salt
• Polyinosinic Acid (5') Potassium Salt
• Polyinosinic acid potassium salt
• Potassium poly(I)
• Potassium ((2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-2-yl)methyl hydrogen phosphate
• POLY[I] POTASSIUM SALT
• Polyinosinic acid potassium salt (PI-K)
• Polyinosinic acid potassium salt Homopolymer
• polyinosinic acid (5') potassium
• POLYINOSIC ACID, POTASSIUM SALT extrapure
• POLYINOSINIC ACID TRIPOTASSIUM SALT
• Potassium polyinosinate
• Polyinosinic Acid Potassium Salt (POLY I Potassium) extrapure
• POLY RL POTASSIUM SALT
• Poly I-K

Polyinosinic Acid Potassium Salt (POLY I Potassium) extrapure

CAS: 26936-41-4

Color and Shape: White to pale yellow, Powder

Ref: SR-62995

Polyinosinic acid tripotassium salt

CAS: 26936-41-4

Polyinosinic acid is a single stranded RNA analog which is combined with polycytidylic acid (poly C) to form a stable duplex structure known as Polyinosinic acid-polycytidylic acid (Poly I:C). PolyI:C stimulates the secretion of pro-inflammatory cytokines and type I interferon through its interaction with endosomal Toll-like receptor 3 (TLR-3) and the cytoplasmic receptors melanoma differentiation-associated gene 5 (MDA-5) and retinoic acid-inducible gene I (RIG-I). This immunostimulant activity makes Poly I:C a useful vaccine adjuvant and is used in vaccine formulations.  Poly I:C and its stabilized analogs (e.g., poly-ICLC) are also being actively researched for their dual role in oncology: directly targeting tumors and acting as immune potentiators. For example Poly I:C can induce apoptosis in tumor cells and stimulate immunogenic cell death and is therefore being explored alongside chemotherapy, radiotherapy, and checkpoint inhibitors, helping to overcome resistance mechanisms and strengthen treatment outcomes. We can supply PolyI:C to all stages of your project - from R&D and preclinical phases right up to GMP commercial manufacture. Contact our team for custom Poly I:C products.
For more on poly I:C read out blog 'Poly I:C: A Vaccine Adjuvant With Oncological Potential.'

Purity: Min. 95%

Ref: 3D-TP65775