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CAS 269396-57-8

:

Fmoc-(R)-3-amino-4-(3,4-dichloro-phenyl)-butyric acid

Description:
Fmoc-(R)-3-amino-4-(3,4-dichloro-phenyl)-butyric acid is a chemical compound commonly used in peptide synthesis and drug development. It features a fluorene-9-methoxycarbonyl (Fmoc) protecting group, which is widely utilized in solid-phase peptide synthesis due to its stability under basic conditions and ease of removal under mild acidic conditions. The compound contains an amino acid structure with a chiral center, indicated by the (R) configuration, which is crucial for biological activity and specificity. The presence of a 3,4-dichlorophenyl group enhances its lipophilicity and may influence its interaction with biological targets. This compound is typically characterized by its molecular weight, solubility in organic solvents, and stability under various pH conditions. Its applications extend to the synthesis of peptide-based therapeutics and research in medicinal chemistry, where the modification of amino acids can lead to the development of novel compounds with desired pharmacological properties. Safety and handling precautions should be observed due to the presence of chlorine substituents, which may pose environmental and health risks.
Formula:C25H21Cl2NO4
InChI:InChI=1/C25H21Cl2NO4/c26-22-10-9-15(12-23(22)27)11-16(13-24(29)30)28-25(31)32-14-21-19-7-3-1-5-17(19)18-6-2-4-8-20(18)21/h1-10,12,16,21H,11,13-14H2,(H,28,31)(H,29,30)/t16-/m1/s1
SMILES:c1ccc2c(c1)c1ccccc1C2COC(=N[C@H](Cc1ccc(c(c1)Cl)Cl)CC(=O)O)O
Synonyms:
  • (3R)-4-(3,4-dichlorophenyl)-3-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}butanoic acid
  • Fmoc-D-β-HoPhe(3,4-DiCl)-OH
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