CAS 269410-08-4

1H-Pyrazole-4-boronic acid pinacol ester

Description:

1H-Pyrazole-4-boronic acid pinacol ester is an organoboron compound characterized by the presence of a pyrazole ring and a boronic acid moiety. This compound typically exhibits a white to off-white solid appearance and is soluble in common organic solvents such as dichloromethane and ethanol. The boronic acid functionality allows for participation in various chemical reactions, particularly in Suzuki coupling reactions, making it valuable in organic synthesis and medicinal chemistry. The pinacol ester group enhances the stability of the boronic acid, facilitating its handling and storage. Additionally, the compound may exhibit moderate to high reactivity due to the presence of the boron atom, which can form complexes with various nucleophiles. Its unique structure and reactivity profile make it a useful intermediate in the synthesis of pharmaceuticals and agrochemicals. As with many boron-containing compounds, care should be taken when handling due to potential reactivity and toxicity.

Formula: C₉H₁₅BN₂O₂

InChI: InChI=1/C9H15BN2O2/c1-8(2)9(3,4)14-10(13-8)7-5-11-12-6-7/h5-6H,1-4H3,(H,11,12)

SMILES: CC1(C)C(C)(C)OB(c2c[nH]nc2)O1

Synonyms:

• 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
• Pyrazole-4-boronicacidpinacolester
• Pyrazole-4-boronic acid pinacol ester
• 4-Pyrazoleboronic acid pinacol ester

1H-Pyrazole-4-boronic acid pinacol ester, 98%

CAS: 269410-08-4

1H-Pyrazole-4-boronic acid pinacol ester is a useful reagent for Suzuki-Miyaura cross-couplings as well as Ruthenium-catalyzed asymmetric hydrogenation. It is also used as reagent for preparing VEGF, Aurora, RHO (ROCK), Janus Kinase 2, c-MET, ALK, S-nitrsoflutathione reductase, CDC7, Acetyl-CoA carb

Formula: C₉H₁₅BN₂O₂

Purity: 98%

Color and Shape: Crystals or powder or crystalline powder, White to cream to pale brown

Molecular weight: 194.04

Ref: 02-L19654

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, min. 97%

CAS: 269410-08-4

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, min. 97%

Formula: C₉H₁₅BN₂O₂

Purity: min. 97%

Color and Shape: off-white to tan pwdr.

Molecular weight: 194.04

Ref: 08-05-1048

1H-Pyrazole-4-Boronic Acid Pinacol Ester

CAS: 269410-08-4

Formula: C₉H₁₅BN₂O₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 194.0386

Ref: IN-DA0032RW

1H-Pyrazole-4-boronic acid, pinacol ester

CAS: 269410-08-4

1H-Pyrazole-4-boronic acid, pinacol ester

Formula: C₉H₁₅BN₂O₂

Purity: ≥95%

Color and Shape: white powder

Molecular weight: 194.03859g/mol

Ref: 54-OR11023

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole

CAS: 269410-08-4

Formula: C₉H₁₅BN₂O₂

Purity: >97.0%(GC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 194.04

Ref: 3B-T2756

Baricitinib Impurity 24

CAS: 269410-08-4

Formula: C₉H₁₅BN₂O₂

Molecular weight: 194.04

Ref: 4Z-B-154027

4-Pyrazoleboronic acid pinacol ester

CAS: 269410-08-4

4-Pyrazoleboronic acid pinacol ester is an organic compound that is the product of a bifunctional coupling reaction between 4-pyrazolecarboxylic acid and pinacol. It has been shown to inhibit protein S6 kinase, which is involved in the regulation of cell growth and proliferation. This compound has also been shown to be effective against cancer cells, including those that are resistant to conventional chemotherapeutic drugs. 4-Pyrazoleboronic acid pinacol ester may also be used as a precursor for other compounds with pharmaceutical activity.

Formula: C₉H₁₅BN₂O₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 194.04 g/mol

Ref: 3D-FP11151

4-(4,4,5,5-Tetramethyl-1,3,2- dioxaborolan-2-yl)-1H-pyrazole

CAS: 269410-08-4

Formula: C₉H₁₅BN₂O₂

Purity: 97%

Color and Shape: Solid, Chunks or Crystalline Powder

Molecular weight: 194.04

Ref: 10-F010845

4-Pyrazoleboronic Acid Pinacol Ester

Controlled Product

CAS: 269410-08-4

Applications 4-Pyrazoleboronic Acid Pinacol Ester is used in the preparation of Rho kinase (ROCK) inhibitors as wella s other biologically active compounds.
References Chowdhury, S. et al.: Bioorg. Med. Chem. Lett., 21, 7107 (2011);

Formula: C₉H₁₅BN₂O₂

Color and Shape: Neat

Molecular weight: 194.04

Ref: TR-P842200

Baricitinib Impurity 35

CAS: 269410-08-4

Formula: C₉H₁₅BN₂O₂

Molecular weight: 194.04

Ref: ST-EA-CP-B31043