CAS 26944-48-9

Glibornuride

Description:

Glibornuride is an oral hypoglycemic agent belonging to the class of sulfonylureas, primarily used in the management of type 2 diabetes mellitus. It functions by stimulating insulin secretion from the pancreatic beta cells, thereby lowering blood glucose levels. The chemical structure of Glibornuride includes a sulfonylurea moiety, which is essential for its pharmacological activity. It is typically administered in tablet form and is often used in conjunction with diet and exercise to improve glycemic control. The substance is characterized by its moderate solubility in water and is generally well-absorbed in the gastrointestinal tract. Common side effects may include hypoglycemia, weight gain, and gastrointestinal disturbances. As with other sulfonylureas, it is contraindicated in patients with type 1 diabetes or diabetic ketoacidosis. Monitoring of blood glucose levels is essential during treatment to avoid potential complications. Overall, Glibornuride plays a significant role in diabetes management, particularly for patients who require additional glycemic control beyond lifestyle modifications.

Formula: C₁₈H₂₆N₂O₄S

InChI: InChI=1S/C18H26N2O4S/c1-11-5-7-12(8-6-11)25(23,24)20-16(22)19-14-13-9-10-18(4,15(14)21)17(13,2)3/h5-8,13-15,21H,9-10H2,1-4H3,(H2,19,20,22)/t13-,14+,15+,18+/m1/s1

InChI key: InChIKey=RMTYNAPTNBJHQI-LLDVTBCESA-N

SMILES: C[C@@]12C(C)(C)[C@@]([C@H](NC(NS(=O)(=O)C3=CC=C(C)C=C3)=O)[C@@H]1O)(CC2)[H]

Synonyms:

• Benzenesulfonamide, N-[[(3-hydroxy-4,7,7-trimethylbicyclo[2.2.1]hept-2-yl)amino]carbonyl]-4-methyl-, [1S-(endo,endo)]-
• Benzenesulfonamide, N-[[[(1S,2S,3R,4R)-3-hydroxy-4,7,7-trimethylbicyclo[2.2.1]hept-2-yl]amino]carbonyl]-4-methyl-
• Gluboride
• Glutril
• N-[(3-hydroxy-4,7,7-trimethylbicyclo[2.2.1]hept-2-yl)carbamoyl]-4-methylbenzenesulfonamide
• N-[[[(1S,2S,3R,4R)-3-Hydroxy-4,7,7-trimethylbicyclo[2.2.1]hept-2-yl]amino]carbonyl]-4-methylbenzenesulfonamide
• Ro 6-4563
• Ro 6-4563/8
• Urea, 1-(2-hydroxy-3-bornyl)-3-(p-tolylsulfonyl)-, (1R,2R,3S,4S)-
• endo, endo-1-[(1R)-(2-Hydroxy-3-bornyl)]-3-(p-tolylsulfonyl)urea
• endo,endo-1-(2-Hydroxy-3-bornyl)-3-(p-tolylsulfonyl)urea

Glibornuride

CAS: 26944-48-9

Formula: C₁₈H₂₆N₂O₄S

Purity: 98%

Color and Shape: Solid

Molecular weight: 366.4750

Ref: IN-DA00C2N3

Glibornuride

CAS: 26944-48-9

Glibornuride

Purity: ≥98%

Molecular weight: 366.48g/mol

Ref: 54-BUP04349

Glibornuride

CAS: 26944-48-9

Formula: C₁₈H₂₆N₂O₄S

Molecular weight: 366.48

Ref: 4Z-G-172

Glibornuride

Controlled Product

CAS: 26944-48-9

Applications Glibornuride has been shown to antagonize the relaxant response to the K+ channel opener cromakalim and produce airway smooth muscle relaxation. Glibornuride is associated with lactic acidosis and hypoglycemia in patients with type 2 diabetes melitus.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Mielsen-Kudsk, J.E., Thirstrup, S.: Pulm. Pharmacol., 6, 185 (1993); Bodmer, M., et. al.: Diabetes Care, 31, 2086 (2008)

Formula: C₁₈H₂₆N₂O₄S

Color and Shape: White To Off-White

Molecular weight: 366.48

Ref: TR-G409700

Glibornuride-d7

Controlled Product

CAS: 26944-48-9

Formula: C₁₈D₇H₁₉N₂O₄S

Color and Shape: Neat

Molecular weight: 373.518

Ref: TR-G409702

Glibornuride

CAS: 26944-48-9

Glibornuride is a blocker of ATP-sensitive K+ channel(pKi: 5.75).

Formula: C₁₈H₂₆N₂O₄S

Purity: 99.5%

Color and Shape: Solid

Molecular weight: 366.48

Ref: TM-T15385