CAS 27007-85-8

1-Thia-4,8-diazaspiro[4.5]decan-3-one, 8-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-, hydrochloride (1:1)

Description:

1-Thia-4,8-diazaspiro[4.5]decan-3-one, 8-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-, hydrochloride (1:1), with CAS number 27007-85-8, is a chemical compound characterized by its complex structure that includes a spirocyclic framework and a phenothiazine moiety. This compound features a thiazine ring and multiple nitrogen atoms, contributing to its potential biological activity. The presence of the chloro substituent on the phenothiazine enhances its pharmacological properties, making it of interest in medicinal chemistry, particularly for its potential neuroactive effects. As a hydrochloride salt, it is typically more soluble in water, facilitating its use in various formulations. The compound may exhibit properties such as antipsychotic or antidepressant effects, similar to other phenothiazine derivatives. Its synthesis and characterization involve standard organic chemistry techniques, and it is important to handle it with care due to the presence of chlorine, which can impart toxicity. Overall, this compound represents a unique intersection of structural complexity and potential therapeutic application.

Formula: C₂₂H₂₄ClN₃OS₂·ClH

InChI: InChI=1S/C22H24ClN3OS2.ClH/c23-16-6-7-20-18(14-16)26(17-4-1-2-5-19(17)29-20)11-3-10-25-12-8-22(9-13-25)24-21(27)15-28-22;/h1-2,4-7,14H,3,8-13,15H2,(H,24,27);1H

InChI key: InChIKey=JRSBQVOEILNXGS-UHFFFAOYSA-N

SMILES: C(CCN1CCC2(CC1)NC(=O)CS2)N3C=4C(SC=5C3=CC=CC5)=CC=C(Cl)C4.Cl

Synonyms:

• APY 606
• 1-Thia-4,8-diazaspiro[4.5]decan-3-one, 8-[3-(2-chlorophenothiazin-10-yl)propyl]-, monohydrochloride
• 8-[3-(2-Chloro-10-phenothiazinyl)propyl]-3-oxo-1-thia-4,8-diazaspiro[4,5]decane monohydrochloride
• 1-Thia-4,8-diazaspiro[4.5]decan-3-one, 8-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-, monohydrochloride
• 1-Thia-4,8-diazaspiro[4.5]decan-3-one, 8-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-, hydrochloride (1:1)

Spiclomazine HCl

CAS: 27007-85-8

Spiclomazine HCl induced apoptosis in pancreatic cancer cells, which was generally related to cell viability, migration, and invasion.

Formula: C₂₂H₂₅Cl₂N₃OS₂

Color and Shape: Solid

Molecular weight: 482.49

Ref: TM-T34695