CAS 2703051-80-1

L-Lysine, N6-[4-(4-iodophenyl)-1-oxobutyl]-, 1,1-dimethylethyl ester

Description:

L-Lysine, N6-[4-(4-iodophenyl)-1-oxobutyl]-, 1,1-dimethylethyl ester, identified by CAS number 2703051-80-1, is a synthetic derivative of the amino acid lysine. This compound features a lysine backbone modified with a 4-(4-iodophenyl)-1-oxobutyl group at the N6 position, along with a tert-butyl ester functional group. The presence of the iodine atom suggests potential applications in medicinal chemistry, particularly in the development of radiolabeled compounds for imaging or therapeutic purposes. The tert-butyl ester moiety enhances lipophilicity, which may improve the compound's bioavailability and membrane permeability. As a derivative of lysine, it retains the basic amino acid characteristics, including the ability to participate in hydrogen bonding and ionic interactions. The compound's structure may also influence its reactivity and interactions with biological targets, making it of interest in pharmaceutical research. However, specific biological activity, solubility, and stability data would require further investigation through experimental studies.

Formula: C₂₀H₃₁IN₂O₃

Synonyms:

• L-Lysine, N6-[4-(4-iodophenyl)-1-oxobutyl]-, 1,1-dimethylethyl ester

Lys(CO-C3-p-I-Ph)-O-tBu

CAS: 2703051-80-1

Lys(CO-C3-p-I-Ph)-O-tBu, a pharmacokinetic modifier (PK modifier), enhances the pharmacokinetic properties of PSMA ligand molecules by increasing their residence time in plasma through improved binding to albumin and reducing absorption by the salivary glands, potentially extending the active compound's half-life. Moreover, Ac-PSMA-trillium is an effective PSMA-targeting compound for various biological applications when modified with different radioactive isotopes. When labeled with 111 In, it serves as a DOTA chelating agent and imaging agent. Alternatively, when labeled with 225 Ac, it acts as a Macropa chelator for targeted radionuclide therapy (TRT) in researching metastatic castration-resistant prostate cancer (mCRPC) [1] [2].

Formula: C₂₀H₃₁IN₂O₃

Color and Shape: Solid

Molecular weight: 474.38

Ref: TM-T86837