CAS 27046-19-1

4-Ketocyclophosphamide

Description:

4-Ketocyclophosphamide, with the CAS number 27046-19-1, is a chemical compound that belongs to the class of alkylating agents, specifically a derivative of cyclophosphamide. It is characterized by the presence of a ketone functional group at the fourth position of the cyclophosphamide structure, which influences its reactivity and biological activity. This compound is primarily known for its role in cancer therapy, as it can form DNA cross-links, thereby inhibiting DNA replication and transcription in rapidly dividing cells. 4-Ketocyclophosphamide is typically administered in a prodrug form, requiring metabolic activation to exert its therapeutic effects. Its solubility and stability can vary depending on the formulation and conditions, making it essential to consider these factors in pharmaceutical applications. Additionally, like other alkylating agents, it may have associated side effects, including myelosuppression and potential toxicity to normal tissues, necessitating careful monitoring during treatment. Overall, 4-Ketocyclophosphamide is an important compound in oncology, contributing to the development of effective chemotherapy regimens.

Formula: C₇H₁₃Cl₂N₂O₃P

InChI: InChI=1/C7H13Cl2N2O3P/c8-2-4-11(5-3-9)15(13)10-7(12)1-6-14-15/h1-6H2,(H,10,12,13)

InChI key: InChIKey=VBMZHOCORXMDJU-UHFFFAOYSA-N

SMILES: N(CCCl)(CCCl)P1(=O)NC(=O)CCO1

Synonyms:

• 2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2,4-dioxide
• 4-Ketocyclophosphamide
• 4-Oxocyclophosphamide
• 4H-1,3,2-oxazaphosphorin-4-one, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide
• Asta 5160
• NSC 139488
• 2-[Bis(2-chloroethyl)amino]tetrahydro-4H-1,3,2-oxazaphosphorin-4-one 2-oxide
• 4-Oxo Cyclophosphamide
• 2-[bis(2-chloroethyl)amino]-2-oxo-1,3,2λ
• 5
• -oxazaphosphinan-4-one

4-Oxo Cyclophosphamide

CAS: 27046-19-1

Formula: C₇H₁₃Cl₂N₂O₃P

Color and Shape: White To Off-White Solid

Molecular weight: 275.07

Ref: 4Z-C-10212

4-oxo Cyclophosphamide

CAS: 27046-19-1

4-oxo Cyclophosphamide: inactive cyclophosphamide metabolite formed via 4-hydroxy intermediate.

Formula: C₇H₁₃Cl₂N₂O₃P

Color and Shape: Solid

Molecular weight: 275.07

Ref: TM-T35645

4-Oxo Cyclophosphamide-d8

CAS: 27046-19-1

Formula: C₇H₅D₈Cl₂N₂O₃P

Color and Shape: White To Off-White Solid

Molecular weight: 283.12

Ref: 4Z-C-10214

4-Oxo Cyclophosphamide

CAS: 27046-19-1

Applications A minor metabolite of Cyclophosphamide
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Juma, F., et al.: Br. J. Clin. Pharmacol., 10, 327 (1980), Powers, J., et al.: Cancer Res., 43, 1101 (1983), Hardy, R., et al.: Ther. Drug Monit., 9, 221 (1987),

Formula: C₇H₁₂Cl₂NO₄P

Color and Shape: Neat

Molecular weight: 276.05

Ref: TR-O849900

4-Oxo Cyclophosphamide-d10

Controlled Product

CAS: 27046-19-1

Formula: C₇D₁₀H₃Cl₂N₂O₃P

Color and Shape: Neat

Molecular weight: 285.131

Ref: TR-O849902

4-Oxo Cyclophosphamide

CAS: 27046-19-1

Formula: C₇H₁₃Cl₂N₂O₃P

Molecular weight: 275.07

Ref: ST-EA-CP-C37039