CAS 27127-79-3

Thevetin B

Description:

Thevetin B is a toxic compound primarily derived from the seeds of the Thevetia peruviana plant, commonly known as the yellow oleander. It belongs to the class of cardiac glycosides, which are known for their ability to affect heart function. Thevetin B exhibits a structure that includes a steroid nucleus, which is characteristic of many cardiac glycosides, and it is known to inhibit the Na+/K+ ATPase enzyme, leading to increased intracellular sodium and calcium levels. This mechanism can result in enhanced cardiac contractility but also poses significant risks of toxicity, including arrhythmias and potential fatal outcomes if ingested. Thevetin B is not only of interest in toxicology but also in pharmacology, where its effects on cardiac function are studied. Due to its toxic nature, handling Thevetin B requires caution, and it is not used therapeutically in humans. Its CAS number, 27127-79-3, is a unique identifier that facilitates the tracking and regulation of this compound in scientific literature and databases.

Formula: C₄₂H₆₆O₁₈

InChI: InChI=1S/C42H66O18/c1-18-35(60-38-33(50)31(48)29(46)26(59-38)17-55-37-32(49)30(47)28(45)25(15-43)58-37)36(53-4)34(51)39(56-18)57-21-7-10-40(2)20(14-21)5-6-24-23(40)8-11-41(3)22(9-12-42(24,41)52)19-13-27(44)54-16-19/h13,18,20-26,28-39,43,45-52H,5-12,14-17H2,1-4H3/t18-,20+,21-,22+,23-,24+,25+,26+,28+,29+,30-,31-,32+,33+,34-,35-,36-,37+,38-,39-,40-,41+,42-/m0/s1

InChI key: InChIKey=GZVMBXDQUQRICT-RCGIHWJFSA-N

SMILES: O[C@@]12[C@]3([C@@]([C@]4(C)[C@](CC3)(C[C@@H](O[C@H]5[C@@H](O)[C@H](OC)[C@@H](O[C@@H]6O[C@H](CO[C@@H]7O[C@H](CO)[C@@H](O)[C@H](O)[C@H]7O)[C@@H](O)[C@H](O)[C@H]6O)[C@H](C)O5)CC4)[H])(CC[C@]1(C)[C@H](CC2)C=8COC(=O)C8)[H])[H]

Synonyms:

• (3beta,5beta)-3-{[beta-D-glucopyranosyl-(1-> 6)-beta-D-glucopyranosyl-(1-> 4)-(2xi)-6-deoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl]oxy}-14-hydroxycard-20(22)-enolide
• (3β,5β)-3-[(O-β-<span class="text-smallcaps">D</smallcap>-Glucopyranosyl-(1→6)-O-β-<smallcap>D</smallcap>-glucopyranosyl-(1→4)-6-deoxy-3-O-methyl-α-<smallcap>L</span>-glucopyranosyl)oxy]-14-hydroxycard-20(22)-enolide
• Card-20(22)-enolide, 3-[(O-β-<span class="text-smallcaps">D</smallcap>-glucopyranosyl-(1→6)-O-β-<smallcap>D</smallcap>-glucopyranosyl-(1→4)-6-deoxy-3-O-methyl-α-<smallcap>L</span>-glucopyranosyl)oxy]-14-hydroxy-, (3β,5β)-
• Thevetin B
• card-20(22)-enolide, 3-[[O-beta-D-glucopyranosyl-(1-> 6)-O-beta-D-glucopyranosyl-(1-> 4)-(2xi)-6-deoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl]oxy]-14-hydroxy-, (3beta,5beta)-
• Card-20(22)-enolide, 3-[(O-β-D-glucopyranosyl-(1→6)-O-β-D-glucopyranosyl-(1→4)-6-deoxy-3-O-methyl-α-L-glucopyranosyl)oxy]-14-hydroxy-, (3β,5β)-
• (3β,5β)-3-[(O-β-D-Glucopyranosyl-(1→6)-O-β-D-glucopyranosyl-(1→4)-6-deoxy-3-O-methyl-α-L-glucopyranosyl)oxy]-14-hydroxycard-20(22)-enolide

Thevetin B

CAS: 27127-79-3

Formula: C₄₂H₆₆O₁₈

Purity: 97.5%

Molecular weight: 858.9626

Ref: IN-DA00BHZW

Thevetin B

CAS: 27127-79-3

Thevetin B is a cardiac glycoside and an inhibitor of Na+-, K+-dependent adenosinetriphosphatase (Na+,K+-ATPase) from Thevetia peruviana.

Formula: C₄₂H₆₆O₁₈

Purity: 98%

Color and Shape: Solid

Molecular weight: 858.96

Ref: TM-TN5141

Thevetin B

CAS: 27127-79-3

Formula: C₄₂H₆₆O₁₈

Purity: 95%~99%

Molecular weight: 858.972

Ref: BP-BP4811

Thevetin B

CAS: 27127-79-3

Formula: C₄₂H₆₆O₁₈

Purity: 95%~99%

Molecular weight: 858.972

Ref: BP-SBP02923

Thevetin B

CAS: 27127-79-3

Thevetin B is a cardiac glycoside, which is a type of organic compound known for its potent effects on the heart. This compound is derived from the seeds of *Thevetia peruviana*, also known as the yellow oleander, a plant native to Central and South America. The primary mode of action of Thevetin B involves inhibition of the Na⁺/K⁺-ATPase pump in cardiac cells. This action results in increased intracellular calcium concentration, leading to enhanced cardiac contractility and a positive inotropic effect.

Formula: C₄₂H₆₆O₁₈

Purity: Min. 95%

Molecular weight: 859.96 g/mol

Ref: 3D-CBA12779