CAS 2713618-08-5

(3'R,4'S,5'R)-6"-chloro-4'-(3-chloro-2-fluorophenyl)-N-((1r,4R)-4-(4-(1-(2,6-dioxopiperidin-3-yl)-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)piperidine-1-carbonyl)cyclohexyl)-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3"-indoline]-5'-carboxamide

Description:

The chemical substance with the name "(3'R,4'S,5'R)-6"-chloro-4'-(3-chloro-2-fluorophenyl)-N-((1r,4R)-4-(4-(1-(2,6-dioxopiperidin-3-yl)-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)piperidine-1-carbonyl)cyclohexyl)-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3"-indoline]-5'-carboxamide" and CAS number "2713618-08-5" is a complex organic compound characterized by its intricate molecular structure, which includes multiple chiral centers, halogen substituents, and various functional groups such as amides and carbonyls. This compound likely exhibits significant biological activity due to its structural features, which may interact with specific biological targets. The presence of fluorine and chlorine atoms suggests potential lipophilicity, influencing its pharmacokinetic properties. Additionally, the compound's stereochemistry may play a crucial role in its efficacy and safety profile in therapeutic applications. Overall, this substance represents a sophisticated example of modern medicinal chemistry, designed for potential use in drug development.

Synonyms:

• KT-253
• (3'R,4'S,5'R)-6"-chloro-4'-(3-chloro-2-fluorophenyl)-N-((1r,4R)-4-(4-(1-(2,6-dioxopiperidin-3-yl)-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)piperidine-1-carbonyl)cyclohexyl)-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3"-indoline]-5'-carboxamide

KT-253

CAS: 2713618-08-5

KT-253 is a p53 stabilizer and a PROTAC degrader of MDM2 (DC50=0.4 nM). It inhibits the proliferation of cancer cells RS4;11 with an IC50 of 0.3 nM, induces cell cycle arrest in the G2/M phase, and triggers apoptosis. In mouse models, KT-253 demonstrates antitumor activity. (Pink: ligand for target protein MDM2 ligand 4; Black: linker; Blue: ligand for E3 ligase cereblon)

Formula: C₄₈H₅₂Cl₂FN₇O₆

Color and Shape: Solid

Molecular weight: 912.874

Ref: TM-T204319