CAS 27215-14-1

Neoandrographolide

Description:

Neoandrographolide is a natural compound derived from the plant Andrographis paniculata, commonly known for its medicinal properties. It belongs to the class of diterpenoids and is characterized by its complex bicyclic structure, which contributes to its biological activity. This compound exhibits a range of pharmacological effects, including anti-inflammatory, antioxidant, and antimicrobial properties. Neoandrographolide has been studied for its potential therapeutic applications, particularly in the treatment of various diseases, including infections and inflammatory conditions. Its mechanism of action often involves modulation of signaling pathways and inhibition of pro-inflammatory cytokines. Additionally, it is known to possess hepatoprotective effects, making it of interest in liver health research. The compound is typically extracted from the leaves of the Andrographis plant and can be analyzed using various techniques such as chromatography and spectroscopy to confirm its purity and concentration. Overall, neoandrographolide represents a significant area of interest in natural product chemistry and pharmacology due to its diverse biological activities and potential health benefits.

Formula: C₂₆H₄₀O₈

InChI: InChI=1/C26H40O8/c1-15-5-8-19-25(2,14-33-24-22(30)21(29)20(28)18(13-27)34-24)10-4-11-26(19,3)17(15)7-6-16-9-12-32-23(16)31/h9,17-22,24,27-30H,1,4-8,10-14H2,2-3H3/t17-,18-,19-,20-,21+,22-,24-,25+,26+/m1/s1

InChI key: InChIKey=YGCYRQKJYWQXHG-RDNQFMDVSA-N

SMILES: C[C@]12[C@@]([C@@](CO[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)(C)CCC1)(CCC(=C)[C@H]2CCC=4C(=O)OCC4)[H]

Synonyms:

• (5S,6S,10R)-17-(beta-D-glucopyranosyloxy)-20-oxo-9,19-didehydro-5,6,7,8,9,10,11,12,15-decahydro-20:5,10-dicycloretinal
• 2(5H)-Furanone, 3-[2-[(1R,4aS,5R,8aS)-5-[(β-<span class="text-smallcaps">D</span>-glucopyranosyloxy)methyl]decahydro-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethyl]-
• 2(5H)-Furanone, 3-[2-[5-[(β-<span class="text-smallcaps">D</span>-glucopyranosyloxy)methyl]decahydro-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethyl]-, [1R-(1α,4aβ,5α,8aα)]-
• 3-[2-[(1R,4aS,5R,8aS)-5-[(β-<span class="text-smallcaps">D</span>-Glucopyranosyloxy)methyl]decahydro-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethyl]-2(5H)-furanone
• 3-[2-[(4aS,5R,8aS)-5,8a-Dimethyl-2-methylidene-5-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethyl]-5H-furan-2-one
• 5β,9β<span class="text-smallcaps">H</span>,10α-Labda-8(20),13-dien-16-oic acid, 18-(glucosyloxy)-15-hydroxy-, γ-lactone
• Neoandrographiside
• {(1R,4aS,8aS)-1,4a-dimethyl-6-methylidene-5-[2-(2-oxo-2,5-dihydrofuran-3-yl)ethyl]decahydronaphthalen-1-yl}methyl beta-D-glucopyranoside
• 2(5H)-Furanone, 3-[2-[5-[(β-D-glucopyranosyloxy)methyl]decahydro-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethyl]-, [1R-(1α,4aβ,5α,8aα)]-
• 5β,9βH,10α-Labda-8(20),13-dien-16-oic acid, 18-(glucosyloxy)-15-hydroxy-, γ-lactone
• 2(5H)-Furanone, 3-[2-[(1R,4aS,5R,8aS)-5-[(β-D-glucopyranosyloxy)methyl]decahydro-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethyl]-
• 3-[2-[(1R,4aS,5R,8aS)-5-[(β-D-Glucopyranosyloxy)methyl]decahydro-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethyl]-2(5H)-furanone
• Neoandrographolide
• Neoandrographolide (Neoandrographiside)
• 3-(2-((1S,4aS,5R,8aS)-5,8a-Dimethyl-2-methylene-5-(((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-tetrahydro-2H-pyran-2-yloxy)methyl)-decahydronaphthalen-1-yl)ethyl)furan-2(5H)-one
• Andrographolide Impurity 7
• 19-hydroxy-8(17),13-laboiadien-16,15-olide-o-βD-glucopyranoside
• ANDROGRAPHOLIDE, NEO(P)
• 3-[2-[(1R,4aβ)-5α-[(β-D-Glucopyranosyloxy)methyl]decahydro-5,8aα-dimethyl-2-methylenenaphthalen-1α-yl]ethyl]furan-2(5H)-one
• 3-[2-[(1R,4aS,5R,8aS)-5-[(β-D-Glucopyranosyloxy)methyl]-1,2,3,4,4a,5,6,7,8,8a-decahydro-5,8a-dimethyl-2-methylenenaphthalene-1-yl]ethyl]-2(5H)-furanone
• D-Glucopyranosyloxy)methyl]decahydro-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethyl]-2(5H)-furanone
• ANDROGRAPHOLIDE, NEO-
• ent-19-Hydroxy-8(17),13-labdadien-16,15-olide 19-O-β-D-glucopyranoside
• ANDROGRAPHOLIDE, NEO(SH)
• Neoandrographolide USP/EP/BP
• 4-[2-[(4aS,5R,8aS)-5,8a-dimethyl-2-methylidene-5-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethyl]-2H-furan-5-one

Neoandrographolide

CAS: 27215-14-1

Formula: C₂₆H₄₀O₈

Purity: 98%

Color and Shape: Solid

Molecular weight: 480.5910

Ref: IN-DA00BC02

Neoandrographolide

CAS: 27215-14-1

Neoandrographolide

Purity: ≥98%

Molecular weight: 480.59g/mol

Ref: 54-BUP07499

Neoandrographolide

CAS: 27215-14-1

Formula: C₂₆H₄₀O₈

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 480.59

Ref: 7W-GC5354

Neoandrographolide

CAS: 27215-14-1

Neoandrographolide has antiradical, anti-inflammatory,and hypolipidemic effects, it protects the cardiovascular without significant liver damage. Neoandrographolide as chemosensitizer in S-Jurkat and X chromosome-linked inhibitor of apoptosis protein (XIAP)-overexpressing Jurkat cells, a model for chemoresistance.Neoandrographolide inhibits iNOS and COX-2 expression through inhibiting p38 MAPKs activation.

Formula: C₂₆H₄₀O₈

Purity: 95%~99%

Molecular weight: 480.598

Ref: BP-BP0988

Neoandrographolide

CAS: 27215-14-1

Formula: C₂₆H₄₀O₈

Purity: >98.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 480.60

Ref: 3B-N1127

Neoandrographolide

CAS: 27215-14-1

Neoandrographolide has hypolipidemic, cardio-protective, anti-inflammatory effects, and enhances chemo-sensitivity without major liver harm.

Formula: C₂₆H₄₀O₈

Purity: 98.52% - 99.00%

Color and Shape: Less Columnar Crystal Colorless Columnar Crystal

Molecular weight: 480.59

Ref: TM-T3884

Neoandrographolide

CAS: 27215-14-1

Natural glycoside

Formula: C₂₆H₄₀O₈

Purity: ≥ 95.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 480.6

Ref: 5G-89740

Neoandrographolide

Controlled Product

CAS: 27215-14-1

Applications Neoandrographolide is one of the principle diterpenoids isolated from A. paniculata, a well-recognized medicinal plant in Asia.
References Jarukamjorn, K., et al.: J. Health Sci., 54, 370-381 (2008);

Formula: C₂₆H₄₀O₈

Color and Shape: Neat

Molecular weight: 480.59

Ref: TR-N389913

Neoandrographolide

CAS: 27215-14-1

Neoandrographolide is a diterpene compound that has been shown to have a significant cytotoxic effect on HL-60 cells. It also shows matrix effects in body formation and chemiluminescence. Neoandrographolide is extracted from the plant Andrographis paniculata, which belongs to the family Acanthaceae. This plant has been used historically as a medical herb in China and India for centuries. The extract of this plant has shown anti-inflammatory properties and can be used to treat infectious diseases such as bowel disease.

Formula: C₂₆H₄₀O₈

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 480.6 g/mol

Ref: 3D-MN11576

3-(2-((1R,4aS,5R,8aS)-5,8a-Dimethyl-2-methylene-5-((((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)methyl)decahydronaphthalen-1-yl)ethyl)furan-2(5H)-one

CAS: 27215-14-1

Purity: 98%

Molecular weight: 480.5979919

Ref: 10-F870427