8-Br-cGMP-AM, or 8-bromo-cyclic guanosine monophosphate-acetoxymethyl ester, is a cell-permeable analog of cyclic guanosine monophosphate (cGMP), a crucial second messenger in various physiological processes. This compound is characterized by the presence of a bromine atom at the 8-position of the guanine ring, which enhances its stability and bioactivity compared to natural cGMP. The acetoxymethyl (AM) ester group allows for improved cellular uptake, facilitating its use in experimental settings to study cGMP signaling pathways. Once inside the cell, the AM group is hydrolyzed by esterases, releasing the active cGMP molecule. 8-Br-cGMP-AM is often employed in research to investigate its effects on smooth muscle relaxation, neuronal signaling, and other cGMP-mediated processes. Its ability to mimic the action of endogenous cGMP makes it a valuable tool in pharmacological studies, particularly in understanding the roles of nitric oxide and guanylate cyclase in various biological systems.

8-Br-cGMP-AM

272445-71-3: 8-Br-cGMP-AM, or 8-bromo-cyclic guanosine monophosphate-acetoxymethyl ester, is a cell-permeable analog of cyclic guanosine monophosphate (cGMP), a crucial second messenger in various physiological processes. This compound is characterized by the presence of a bromine atom at the 8-position of the guanine ring, which enhances its stability and bioactivity compared to natural cGMP. The acetoxymethyl (AM) ester group allows for improved cellular uptake, facilitating its use in experimental settings to study cGMP signaling pathways. Once inside the cell, the AM group is hydrolyzed by esterases, releasing the active cGMP molecule. 8-Br-cGMP-AM is often employed in research to investigate its effects on smooth muscle relaxation, neuronal signaling, and other cGMP-mediated processes. Its ability to mimic the action of endogenous cGMP makes it a valuable tool in pharmacological studies, particularly in understanding the roles of nitric oxide and guanylate cyclase in various biological systems.

<p>8-Br-cGMP-AM, a derivative of 8-Br-cGMP, acts as an activator of PKG (cGMP-dependent protein kinase), inducing various biological effects such as vasodilation and platelet inhibition. This compound is utilized in the research of cardiovascular diseases.</p>

CAS 272445-71-3

8-Br-cGMP-AM

8-Br-cGMP-AM

Ref: TM-T88538