CAS 2727088-38-0

5-HT6 inverse agonist 1

CAS: 2727088-38-0

5-HT6 inverse agonist 1 (Compound 33) is an antagonist of the 5-HT6 receptor with a Ki of 23 nM and a Kb of 6.62 nM. This compound can inhibit 5-HT6R-mediated Cdk5 and mTOR signaling pathways and reduce tactile allodynia induced by spinal nerve ligation (SNL) in rat models.

Formula: C₂₂H₂₂Cl₂FN₃O₃S

Color and Shape: Solid

Molecular weight: 498.4

Ref: TM-T203572