DNA crosslinker 6, identified by its CAS number 272791-87-4, is a chemical compound utilized primarily in molecular biology and biochemistry for its ability to form covalent bonds between DNA strands. This crosslinking property is significant in various applications, including the study of DNA-protein interactions, the stabilization of DNA structures, and the development of therapeutic agents targeting cancer cells. The compound typically features a reactive moiety that facilitates the formation of crosslinks, which can impede DNA replication and transcription, thereby serving as a potential mechanism for inducing cytotoxicity in rapidly dividing cells. Additionally, DNA crosslinkers are valuable tools in the field of drug development, particularly in designing chemotherapeutic agents that exploit the vulnerabilities of cancer cells. The specificity and efficiency of DNA crosslinker 6 make it a useful reagent in experimental protocols aimed at understanding DNA dynamics and cellular responses to DNA damage. As with all chemical substances, proper handling and safety precautions are essential when working with this compound in laboratory settings.

DNA crosslinker 6

272791-87-4: DNA crosslinker 6, identified by its CAS number 272791-87-4, is a chemical compound utilized primarily in molecular biology and biochemistry for its ability to form covalent bonds between DNA strands. This crosslinking property is significant in various applications, including the study of DNA-protein interactions, the stabilization of DNA structures, and the development of therapeutic agents targeting cancer cells. The compound typically features a reactive moiety that facilitates the formation of crosslinks, which can impede DNA replication and transcription, thereby serving as a potential mechanism for inducing cytotoxicity in rapidly dividing cells. Additionally, DNA crosslinkers are valuable tools in the field of drug development, particularly in designing chemotherapeutic agents that exploit the vulnerabilities of cancer cells. The specificity and efficiency of DNA crosslinker 6 make it a useful reagent in experimental protocols aimed at understanding DNA dynamics and cellular responses to DNA damage. As with all chemical substances, proper handling and safety precautions are essential when working with this compound in laboratory settings.

DNA crosslinker 6 (compound 1) is an anti-mitotic agent known for its strong binding affinity to AT-DNA and inhibition of AT-hook 1 binding to DNA (IC50=0.03 µM). Additionally, it exhibits anti-protozoal activity, effectively inhibiting T. brucei with an EC50 of 0.83 µM.

CAS 272791-87-4

DNA crosslinker 6

DNA crosslinker 6

Ref: TM-T201475