CAS 2730-71-4

Thiocolchicine

Description:

Thiocolchicine is a chemical compound that is derived from colchicine, a natural alkaloid found in the plant Colchicum autumnale. It is characterized by its structure, which includes a phenolic ring and a thioether group, contributing to its biological activity. The compound is known for its role as a microtubule inhibitor, affecting cell division and mitosis, which makes it of interest in cancer research and treatment. Thiocolchicine exhibits anti-inflammatory properties and has been studied for its potential therapeutic applications in conditions such as gout and other inflammatory diseases. It is typically administered in a crystalline form and is soluble in organic solvents. The compound's mechanism of action involves binding to tubulin, disrupting the polymerization of microtubules, and thereby inhibiting cellular processes. Safety and toxicity profiles are important considerations in its use, as with many alkaloids. Overall, thiocolchicine represents a significant compound in medicinal chemistry, with ongoing research into its pharmacological properties and potential applications.

Formula: C₂₂H₂₅NO₅S

InChI: InChI=1S/C22H25NO5S/c1-12(24)23-16-8-6-13-10-18(26-2)21(27-3)22(28-4)20(13)14-7-9-19(29-5)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1

InChI key: InChIKey=CMEGANPVAXDBPL-INIZCTEOSA-N

SMILES: O(C)C1=C2C=3C([C@@H](NC(C)=O)CCC2=CC(OC)=C1OC)=CC(=O)C(SC)=CC3

Synonyms:

• 10-Demethoxy-10-(methylthio)colchicine
• 10-Demethoxy-10-methylthiocolchicine
• Acetamide, N-(5,6,7,9-tetrahydro-1,2,3-trimethoxy-10-(methylthio)-9-oxobenzo(a)heptalen-7-yl)-
• Acetamide, N-(5,6,7,9-tetrahydro-1,2,3-trimethoxy-10-(methylthio)-9-oxobenzo(a)heptalen-7-yl)-, (S)-
• Acetamide, N-[(7S)-5,6,7,9-tetrahydro-1,2,3-trimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]-
• Benzo[a]heptalene, acetamide deriv.
• Colchicine, 10-demethoxy-10-(methylthio)-
• Colchicine, 10-thio-
• Colchicine, thio-
• N-[(7S)-1,2,3-trimethoxy-10-(methylsulfanyl)-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide
• N-[(7S)-5,6,7,9-Tetrahydro-1,2,3-trimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]acetamide
• Nsc 186301
• Sml 0954

Thiocolchicine

CAS: 2730-71-4

Formula: C₂₂H₂₅NO₅S

Color and Shape: Yellow Solid

Molecular weight: 415.50

Ref: 4Z-T-597

Thiocolchicine

CAS: 2730-71-4

Thiocolchicine

Purity: ≥98%

Molecular weight: 415.5g/mol

Ref: 54-BUP06082

Thiocolchicine

CAS: 2730-71-4

Thiocolchicine inhibits tubulin polymerization (IC50: 2.5 µM, Ki: 0.7 µM), induces apoptosis, and serves as an ADC cytotoxin.

Formula: C₂₂H₂₅NO₅S

Purity: 98.19%

Color and Shape: Solid

Molecular weight: 415.5

Ref: TM-T41248

Thiocolchicine

CAS: 2730-71-4

Formula: C₂₂H₂₅NO₅S

Molecular weight: 415.5

Ref: 7W-GL9350

Thiocolchicine

CAS: 2730-71-4

Thiocolchicine is a colchicine analogue that has been shown to be effective against cancer cells and other types of cells. It binds to the disulfide bond in the VEGF receptor-1, which prevents its activation. Thiocolchicine also inhibits tumor cell proliferation and induces apoptosis by inhibiting protein synthesis. Thiocolchicine has been shown to be cytotoxic in vivo in human serum, as well as liver cells and colchicine-sensitive cancer cells. This drug also has potent antitumor activity in vivo and in vitro.

Formula: C₂₂H₂₅NO₅S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 415.5 g/mol

Ref: 3D-FT28223

Thiocolchicine

CAS: 2730-71-4

Applications A muscle relaxant.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Sharma, S., et al.: Biochem., 49, 2932 (2010), Bartusik, D., et al.: Bioorg. Chem., 38, 1 (2010), Passarella, D., et al.: Eur. J. Med. Chem., 45, 219 (2010),

Formula: C₂₂H₂₅NO₅S

Color and Shape: Neat

Molecular weight: 415.50

Ref: TR-T344390

Thiocolchicoside EP Impurity B

CAS: 2730-71-4

Formula: C₂₂H₂₅NO₅S

Molecular weight: 415.5

Ref: ST-EA-CP-T44002