CAS 2730-71-4: Thiocolchicine

Description:Thiocolchicine is a chemical compound that is derived from colchicine, a natural alkaloid found in the plant Colchicum autumnale. It is characterized by its structure, which includes a phenolic ring and a thioether group, contributing to its biological activity. The compound is known for its role as a microtubule inhibitor, affecting cell division and mitosis, which makes it of interest in cancer research and treatment. Thiocolchicine exhibits anti-inflammatory properties and has been studied for its potential therapeutic applications in conditions such as gout and other inflammatory diseases. It is typically administered in a crystalline form and is soluble in organic solvents. The compound's mechanism of action involves binding to tubulin, disrupting the polymerization of microtubules, and thereby inhibiting cellular processes. Safety and toxicity profiles are important considerations in its use, as with many alkaloids. Overall, thiocolchicine represents a significant compound in medicinal chemistry, with ongoing research into its pharmacological properties and potential applications.

Formula:C₂₂H₂₅NO₅S

InChI:InChI=1S/C22H25NO5S/c1-12(24)23-16-8-6-13-10-18(26-2)21(27-3)22(28-4)20(13)14-7-9-19(29-5)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1

InChI key:InChIKey=CMEGANPVAXDBPL-INIZCTEOSA-N

SMILES:O=C1C=C2C(=CC=C1SC)C3=C(OC)C(OC)=C(OC)C=C3CCC2NC(=O)C

Synonyms:
10-Demethoxy-10-(methylthio)colchicine
10-Demethoxy-10-methylthiocolchicine
Acetamide, N-(5,6,7,9-tetrahydro-1,2,3-trimethoxy-10-(methylthio)-9-oxobenzo(a)heptalen-7-yl)-
Acetamide, N-(5,6,7,9-tetrahydro-1,2,3-trimethoxy-10-(methylthio)-9-oxobenzo(a)heptalen-7-yl)-, (S)-
Acetamide, N-[(7S)-5,6,7,9-tetrahydro-1,2,3-trimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]-
Benzo[a]heptalene, acetamide deriv.
Colchicine, 10-demethoxy-10-(methylthio)-
Colchicine, 10-thio-
Colchicine, thio-
N-[(7S)-1,2,3-trimethoxy-10-(methylsulfanyl)-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide
See more synonyms
N-[(7S)-5,6,7,9-Tetrahydro-1,2,3-trimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]acetamide
Nsc 186301
Sml 0954
Thiocholchicine

Found 6 products.

Product data	Purity	Price range	Estimated delivery
Thiocolchicine REF: 54-BUP06082CAS: 2730-71-4	98.19%	198.00 €~494.00 €	Mon 21 Apr 25
Thiocolchicine REF: TM-T41248CAS: 2730-71-4	98.19%	40.00 €~324.00 €	Mon 21 Apr 25
Thiocolchicine REF: 4Z-T-597CAS: 2730-71-4	- - -	To inquire	Mon 21 Apr 25
Thiocolchicine REF: 7W-GL9350CAS: 2730-71-4	- - -	101.00 €~259.00 €	Thu 24 Apr 25
Thiocolchicine REF: 3D-FT28223CAS: 2730-71-4	Min. 95%	147.00 €~5,258.00 €	Mon 28 Apr 25
Thiocolchicine REF: TR-T344390CAS: 2730-71-4	- - -	128.00 €~791.00 €	Wed 28 May 25