CAS 273404-37-8: N-(4-Amino-3-chlorobenzoyl)-3-methyl-L-valyl-N-[(2R,3S)-2-ethoxytetrahydro-5-oxo-3-furanyl]-L-prolinamide

Description: N-(4-Amino-3-chlorobenzoyl)-3-methyl-L-valyl-N-[(2R,3S)-2-ethoxytetrahydro-5-oxo-3-furanyl]-L-prolinamide, with CAS number 273404-37-8, is a complex organic compound characterized by its multi-functional structure. It features an amide linkage, which is indicative of its potential biological activity, particularly in pharmaceutical applications. The presence of an amino group and a chlorobenzoyl moiety suggests that it may exhibit properties related to amino acid derivatives and could interact with biological systems, possibly influencing protein synthesis or enzyme activity. The ethoxytetrahydrofuran component adds to its structural diversity, potentially enhancing solubility and bioavailability. This compound may be of interest in medicinal chemistry, particularly in the development of therapeutic agents targeting specific biological pathways. Its stereochemistry, indicated by the (2R,3S) configuration, is crucial for its biological activity, as the spatial arrangement of atoms can significantly affect how the molecule interacts with biological targets. Overall, this compound exemplifies the complexity and specificity often found in drug design and development.

Formula: C₂₄H₃₃ClN₄O₆

InChI: InChI=1S/C24H33ClN4O6/c1-5-34-23-16(12-18(30)35-23)27-21(32)17-7-6-10-29(17)22(33)19(24(2,3)4)28-20(31)13-8-9-15(26)14(25)11-13/h8-9,11,16-17,19,23H,5-7,10,12,26H2,1-4H3,(H,27,32)(H,28,31)/t16-,17-,19+,23+/m0/s1

InChI key: InChIKey=SJDDOCKBXFJEJB-MOKWFATOSA-N

SMILES: O=C1OC(OCC)C(NC(=O)C2N(C(=O)C(NC(=O)C3=CC=C(N)C(Cl)=C3)C(C)(C)C)CCC2)C1

Synonyms:

• <span class="text-smallcaps">L</smallcap>-Prolinamide, N-(4-amino-3-chlorobenzoyl)-3-methyl-<smallcap>L</span>-valyl-N-[(2R,3S)-2-ethoxytetrahydro-5-oxo-3-furanyl]-
• Belnacasan
• N-(4-Amino-3-chlorobenzoyl)-3-methyl-<span class="text-smallcaps">L</smallcap>-valyl-N-[(2R,3S)-2-ethoxytetrahydro-5-oxo-3-furanyl]-<smallcap>L</span>-prolinamide
• Vx 765
• Vx765
• VX 786
• N-(4-Amino-3-chlorobenzoyl)-3-methyl-L-valyl-N-[(2R,3S)-2-ethoxytetrahydro-5-oxo-3-furanyl]-L-prolinamide
• L-Prolinamide, N-(4-amino-3-chlorobenzoyl)-3-methyl-L-valyl-N-[(2R,3S)-2-ethoxytetrahydro-5-oxo-3-furanyl]-

N-(4-Amino-3-chlorobenzoyl)-3-methyl-L-valyl-N-[(2R,3S)-2-ethoxytetrahydro-5-oxo-3-furanyl]-L-prolinamide

CAS: 273404-37-8

• Formula: C₂₄H₃₃ClN₄O₆
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 508.9950199999999

Belnacasan

CAS: 273404-37-8

• Purity: ≥98%
• Molecular weight: 508.99g/mol

VX-765

CAS: 273404-37-8

• Formula: C₂₄H₃₃ClN₄O₆
• Purity: >95.0%(HPLC)
• Color and Shape: White to Light yellow powder to crystal
• Molecular weight: 509.00

Belnacasan

CAS: 273404-37-8

Belnacasan (VX-765) is an orally active IL-converting enzyme/caspase-1 inhibitor.

• Formula: C₂₄H₃₃ClN₄O₆
• Purity: 96.53% - 99.5%
• Color and Shape: Solid
• Molecular weight: 508.99

VX-765

CAS: 273404-37-8

Applications VX-765 shows anti-convulsant activity by inhibiting interlukin-1β biosynthesis. References Maroso, M. et al.: Neurother., …

• Formula: C₂₄H₃₃ClN₄O₆
• Color and Shape: Neat
• Molecular weight: 509.00

VX 765

CAS: 273404-37-8

A prodrug of VRT 043198 that inhibits IL-converting enzyme (ICE)/caspase-1. Inhibits LPS-induced secretion of cytokines. …

• Formula: C₂₄H₃₃ClN₄O₆
• Purity: Min. 95%
• Color and Shape: White Powder
• Molecular weight: 508.99 g/mol