CAS 27367-90-4

Niaprazine

Description:

Niaprazine is a chemical compound classified as an antipsychotic and is primarily used for its sedative and anxiolytic properties. It belongs to the class of phenothiazines and is known for its ability to modulate neurotransmitter activity in the brain, particularly affecting dopamine and serotonin pathways. Niaprazine is often utilized in the treatment of sleep disorders and anxiety-related conditions due to its calming effects. The compound is typically administered in oral form and is characterized by its relatively low toxicity profile compared to other sedatives. Its pharmacological effects include sedation, anxiolysis, and potential antidepressant activity. Niaprazine is also noted for its ability to improve sleep quality without significantly altering sleep architecture. However, like many psychotropic medications, it may have side effects, including drowsiness, dizziness, and potential interactions with other medications. As with any pharmaceutical, it is essential for it to be prescribed and monitored by a healthcare professional to ensure safety and efficacy in treatment.

Formula: C₂₀H₂₅FN₄O

InChI: InChI=1/C20H25FN4O/c1-16(23-20(26)17-3-2-9-22-15-17)8-10-24-11-13-25(14-12-24)19-6-4-18(21)5-7-19/h2-7,9,15-16H,8,10-14H2,1H3,(H,23,26)

InChI key: InChIKey=RSKQGBFMNPDPLR-UHFFFAOYSA-N

SMILES: C(CC(NC(=O)C=1C=CC=NC1)C)N2CCN(CC2)C3=CC=C(F)C=C3

Synonyms:

• 1709 Cerm
• 1709Cerm
• 3-Pyridinecarboxamide, N-(3-(4-(4-fluorophenyl)-1-piperazinyl)-1-methylpropyl)- (9CI)
• 3-Pyridinecarboxamide, N-[3-[4-(4-fluorophenyl)-1-piperazinyl]-1-methylpropyl]-
• Brn 0844157
• N-(3-(4-(4-Fluorophenyl)-1-piperazinyl)-1-methylpropyl)-3-pyridinecarboxamide
• N-(3-(4-(p-Fluorophenyl)-1-piperazinyl)-1-methylpropyl)nicotinamide
• N-{4-[4-(4-fluorophenyl)piperazin-1-yl]butan-2-yl}pyridine-3-carboxamide
• Niaprazina
• Niaprazina [INN-Spanish]
• Niaprazine [INN:DCF]
• Niaprazinum
• Niaprazinum [INN-Latin]
• Nicotinamide, N-(3-(4-(p-fluorophenyl)-1-piperazinyl)-1-methylpropyl)-
• Nopron
• Unii-R2H3Yn6E3L
• Niaprazine
• 5-23-01-00362 (Beilstein Handbook Reference)
• N-[3-[4-(4-Fluorophenyl)-1-piperazinyl]-1-methylpropyl]nicotinamide

Niaprazine

CAS: 27367-90-4

Formula: C₂₀H₂₅FN₄O

Purity: 95%

Color and Shape: Solid

Molecular weight: 356.4371

Ref: IN-DA00BGCA

N-(4-(4-(4-Fluorophenyl)piperazin-1-yl)butan-2-yl)nicotinamide

CAS: 27367-90-4

N-(4-(4-(4-Fluorophenyl)piperazin-1-yl)butan-2-yl)nicotinamide

Purity: 95%

Molecular weight: 356.44g/mol

Ref: 54-PC108799

Niaprazine

CAS: 27367-90-4

Niaprazine

Purity: ≥98%

Molecular weight: 356.44g/mol

Ref: 54-BUP10002

Niaprazine

CAS: 27367-90-4

Niaprazine is a histamine H1-receptor antagonist with marked sedative properties.

Formula: C₂₀H₂₅FN₄O

Purity: 99.56%

Color and Shape: Solid

Molecular weight: 356.44

Ref: TM-T36949

Niaprazine

CAS: 27367-90-4

Formula: C₂₀H₂₅FN₄O

Color and Shape: White To Off-White

Molecular weight: 356.437

Ref: TR-N233465

Niaprazine

CAS: 27367-90-4

Niaprazine is a 5-HT2 receptor antagonist that has been used for the treatment of inflammatory bowel disease. It is available as an ester hydrochloride salt, which can be administered orally or parenterally. The drug may be used in conjunction with other drugs to treat symptoms of bowel disease such as abdominal pain, diarrhea, and constipation. Niaprazine has also been shown to have anti-inflammatory effects. It binds to 5-HT2 receptors and inhibits the release of proinflammatory mediators such as prostaglandins and leukotrienes that are involved in the pathogenesis of inflammatory bowel diseases. This mechanism is not well understood but may be due to its ability to inhibit phospholipase A2 enzyme activity or its inhibition of sodium citrate transport across the cell membrane. Niaprazine has also been shown to have some effect on preventing autoimmune diseases in animal models.

Formula: C₂₀H₂₅FN₄O

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 356.44 g/mol

Ref: 3D-FN104313